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• W2155113097 abstract "OBJECTIVES: Existing data support a modest association between cigarette smoking and incident colorectal cancer (CRC) overall. In this study, we evaluated associations between cigarette smoking and CRC risk stratified byKRASmutation status, using data and tissue resources from the Iowa Women's Health Study (IWHS). METHODS: The IWHS is a population-based cohort study of cancer incidence among 41,836 randomly selected Iowa women, ages 55–69 years of age at enrollment (1986). Exposure data, including cigarette smoking, were obtained by self-report at baseline. Incident CRCs (n=1,233) were ascertained by annual linkage with the Iowa Cancer Registry. Archived tissue specimens from CRC cases recorded through 2002 were recently requested for molecular epidemiology investigations. TumorKRASmutation status was determined by direct sequencing of exon 2, with informative results in 507/555 (91%) available CRC cases (342 mutation negative and 165 mutation positive). Multivariate Cox regression models were fit to estimate relative risks (RRs) and 95% confidence intervals (CIs) for associations between cigarette smoking variables andKRAS-defined CRC subtypes. RESULTS: Multiple smoking variables were associated with increased risk forKRASmutation-negative tumors, including age at initiation (P=0.02), average number of cigarettes per day (P=0.01), cumulative pack-years (P=0.05), and induction period (P=0.04), with the highest point estimate observed for women who smoked ≥40 cigarettes per day on average (RR=2.38; 95% CI=1.25–4.51; compared with never smokers). Further consideration of CRC subsite suggested that cigarette smoking may be a stronger risk factor forKRASmutation-negative tumors located in the proximal colon than in the distal colorectum. None of the smoking variables were significantly associated withKRASmutation-positive CRCs (overall or stratified by anatomic subsite). CONCLUSIONS: Data from this prospective study of older women demonstrate differential associations between cigarette smoking and CRC subtypes defined byKRASmutation status, and are consistent with the hypothesis that smoking adversely affects the serrated pathway of colorectal carcinogenesis." @default.
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• W2155113097 date "2012-05-01" @default.
• W2155113097 modified "2023-10-16" @default.
• W2155113097 title "Cigarette Smoking and Colorectal Cancer Risk by KRAS Mutation Status Among Older Women" @default.
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• W2155113097 doi "https://doi.org/10.1038/ajg.2012.21" @default.
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