FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155114598> ?p ?o ?g. }

• W2155114598 endingPage "1509" @default.
• W2155114598 startingPage "1501" @default.
• W2155114598 abstract "TopBP1, acting in concert with DNA containing bulky base lesions, stimulates ATR kinase activity under physiologically relevant reaction conditions. Here, we analyze the roles of the three components in ATR activation: DNA, base damage and TopBP1. We show that base adducts caused by a potent carcinogen, benzo[a]pyrene diol epoxide (BPDE), constitute a strong signal for TopBP1-dependent ATR kinase activity on Chk1 and p53. We find that the C-terminus of TopBP1 binds preferentially to damaged DNA and is sufficient to mediate damaged DNA-dependent ATR activation in a manner similar to full-length TopBP1. Significantly, we find that stimulation of ATR by BPDE-damaged DNA exhibits strong dependence on the length of DNA, with essentially no stimulation with fragments of 0.2 kb and reaching maximum stimulation with 2 kb fragments. Moreover, TopBP1 shows preferential binding to longer DNA fragments and, in contrast to previous biochemical studies, TopBP1 binding is completely independent of DNA ends. We find that TopBP1 binds to circular and linear DNAs with comparable affinities and that these DNA forms elicit the same level of TopBP1-dependent ATR activation. Taken together, these findings suggest a cooperative activation mechanism for the ATR checkpoint kinase by TopBP1 and damaged DNA." @default.
• W2155114598 created "2016-06-24" @default.
• W2155114598 creator A5005229561 @default.
• W2155114598 creator A5016678671 @default.
• W2155114598 creator A5019132282 @default.
• W2155114598 date "2009-01-09" @default.
• W2155114598 modified "2023-09-26" @default.
• W2155114598 title "Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA" @default.
• W2155114598 cites W1967630574 @default.
• W2155114598 cites W1968222794 @default.
• W2155114598 cites W1975767581 @default.
• W2155114598 cites W1981504084 @default.
• W2155114598 cites W1983410191 @default.
• W2155114598 cites W1992876574 @default.
• W2155114598 cites W2015174686 @default.
• W2155114598 cites W2020651808 @default.
• W2155114598 cites W2029369774 @default.
• W2155114598 cites W2030829729 @default.
• W2155114598 cites W2043895957 @default.
• W2155114598 cites W2052410309 @default.
• W2155114598 cites W2062284662 @default.
• W2155114598 cites W2065588235 @default.
• W2155114598 cites W2084089807 @default.
• W2155114598 cites W2084745121 @default.
• W2155114598 cites W2102752109 @default.
• W2155114598 cites W2110133994 @default.
• W2155114598 cites W2116184125 @default.
• W2155114598 cites W2123605678 @default.
• W2155114598 cites W2127251317 @default.
• W2155114598 cites W2127720624 @default.
• W2155114598 cites W2128252882 @default.
• W2155114598 cites W2128322002 @default.
• W2155114598 cites W2130027970 @default.
• W2155114598 cites W2139697903 @default.
• W2155114598 cites W2150587707 @default.
• W2155114598 cites W2151214957 @default.
• W2155114598 cites W2162891049 @default.
• W2155114598 cites W2321418341 @default.
• W2155114598 doi "https://doi.org/10.1093/nar/gkn1075" @default.
• W2155114598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2655664" @default.
• W2155114598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19139065" @default.
• W2155114598 hasPublicationYear "2009" @default.
• W2155114598 type Work @default.
• W2155114598 sameAs 2155114598 @default.
• W2155114598 citedByCount "39" @default.
• W2155114598 countsByYear W21551145982012 @default.
• W2155114598 countsByYear W21551145982013 @default.
• W2155114598 countsByYear W21551145982014 @default.
• W2155114598 countsByYear W21551145982015 @default.
• W2155114598 countsByYear W21551145982016 @default.
• W2155114598 countsByYear W21551145982017 @default.
• W2155114598 countsByYear W21551145982018 @default.
• W2155114598 countsByYear W21551145982020 @default.
• W2155114598 countsByYear W21551145982021 @default.
• W2155114598 countsByYear W21551145982022 @default.
• W2155114598 countsByYear W21551145982023 @default.
• W2155114598 crossrefType "journal-article" @default.
• W2155114598 hasAuthorship W2155114598A5005229561 @default.
• W2155114598 hasAuthorship W2155114598A5016678671 @default.
• W2155114598 hasAuthorship W2155114598A5019132282 @default.
• W2155114598 hasBestOaLocation W21551145981 @default.
• W2155114598 hasConcept C104317684 @default.
• W2155114598 hasConcept C105696609 @default.
• W2155114598 hasConcept C12554922 @default.
• W2155114598 hasConcept C143425029 @default.
• W2155114598 hasConcept C153911025 @default.
• W2155114598 hasConcept C185581394 @default.
• W2155114598 hasConcept C29537977 @default.
• W2155114598 hasConcept C54086632 @default.
• W2155114598 hasConcept C552990157 @default.
• W2155114598 hasConcept C55493867 @default.
• W2155114598 hasConcept C68748289 @default.
• W2155114598 hasConcept C86803240 @default.
• W2155114598 hasConcept C95444343 @default.
• W2155114598 hasConceptScore W2155114598C104317684 @default.
• W2155114598 hasConceptScore W2155114598C105696609 @default.
• W2155114598 hasConceptScore W2155114598C12554922 @default.
• W2155114598 hasConceptScore W2155114598C143425029 @default.
• W2155114598 hasConceptScore W2155114598C153911025 @default.
• W2155114598 hasConceptScore W2155114598C185581394 @default.
• W2155114598 hasConceptScore W2155114598C29537977 @default.
• W2155114598 hasConceptScore W2155114598C54086632 @default.
• W2155114598 hasConceptScore W2155114598C552990157 @default.
• W2155114598 hasConceptScore W2155114598C55493867 @default.
• W2155114598 hasConceptScore W2155114598C68748289 @default.
• W2155114598 hasConceptScore W2155114598C86803240 @default.
• W2155114598 hasConceptScore W2155114598C95444343 @default.
• W2155114598 hasIssue "5" @default.
• W2155114598 hasLocation W21551145981 @default.
• W2155114598 hasLocation W21551145982 @default.
• W2155114598 hasLocation W21551145983 @default.
• W2155114598 hasLocation W21551145984 @default.
• W2155114598 hasLocation W21551145985 @default.
• W2155114598 hasOpenAccess W2155114598 @default.
• W2155114598 hasPrimaryLocation W21551145981 @default.
• W2155114598 hasRelatedWork W1965019589 @default.
• W2155114598 hasRelatedWork W1965980401 @default.
• W2155114598 hasRelatedWork W2067804796 @default.

• next