FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155116005> ?p ?o ?g. }

• W2155116005 endingPage "7233" @default.
• W2155116005 startingPage "7224" @default.
• W2155116005 abstract "Abstract To investigate human basophil responses to chemokines, we have developed a sensitive assay that uses flow cytometry to measure leukocyte shape change as a marker of cell responsiveness. PBMC were isolated from the blood of volunteers. Basophils were identified as a single population of cells that stained positive for IL-3Rα (CDw123) and negative for HLA-DR, and their increase in forward scatter (as a result of cell shape change) in response to chemokines was measured. Shape change responses of basophils to chemokines were highly reproducible, with a rank order of potency: monocyte chemoattractant protein (MCP) 4 (peak at &lt;1 nM) ≥ eotaxin-2 = eotaxin-3 ≥ eotaxin &gt; MCP-1 = MCP-3 &gt; macrophage-inflammatory protein-1α &gt; RANTES = MCP-2 = IL-8. The CCR4-selective ligand macrophage-derived chemokine did not elicit a response at concentrations up to 10 nM. Blocking mAbs to CCR2 and CCR3 demonstrated that responses to higher concentrations (&gt;10 nM) of MCP-1 were mediated by CCR3 rather than CCR2, whereas MCP-4 exhibited a biphasic response consistent with sequential activation of CCR3 at lower concentrations and CCR2 at 10 nM MCP-4 and above. In contrast, responses to MCP-3 were blocked only in the presence of both mAbs, but not after pretreatment with either anti-CCR2 or anti-CCR3 mAb alone. These patterns of receptor usage were different from those seen for eosinophils and monocytes. We suggest that cooperation between CCRs might be a mechanism for preferential recruitment of basophils, as occurs in tissue hypersensitivity responses in vivo." @default.
• W2155116005 created "2016-06-24" @default.
• W2155116005 creator A5000219202 @default.
• W2155116005 creator A5006321692 @default.
• W2155116005 creator A5008452248 @default.
• W2155116005 creator A5012208330 @default.
• W2155116005 creator A5032808351 @default.
• W2155116005 creator A5033052914 @default.
• W2155116005 creator A5052511743 @default.
• W2155116005 creator A5064418813 @default.
• W2155116005 creator A5079322951 @default.
• W2155116005 date "2000-12-15" @default.
• W2155116005 modified "2023-10-04" @default.
• W2155116005 title "Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling" @default.
• W2155116005 cites W1496902090 @default.
• W2155116005 cites W1525454209 @default.
• W2155116005 cites W1525545531 @default.
• W2155116005 cites W1530360057 @default.
• W2155116005 cites W1534443727 @default.
• W2155116005 cites W1545159719 @default.
• W2155116005 cites W1557765112 @default.
• W2155116005 cites W1568757285 @default.
• W2155116005 cites W1604941563 @default.
• W2155116005 cites W1607098455 @default.
• W2155116005 cites W1612149354 @default.
• W2155116005 cites W1639614093 @default.
• W2155116005 cites W1852077611 @default.
• W2155116005 cites W1902051780 @default.
• W2155116005 cites W1973677690 @default.
• W2155116005 cites W1981773032 @default.
• W2155116005 cites W1983879962 @default.
• W2155116005 cites W1984015030 @default.
• W2155116005 cites W1991458677 @default.
• W2155116005 cites W2000092232 @default.
• W2155116005 cites W2001309910 @default.
• W2155116005 cites W2015506599 @default.
• W2155116005 cites W2020392502 @default.
• W2155116005 cites W2026931929 @default.
• W2155116005 cites W2027040241 @default.
• W2155116005 cites W2033043906 @default.
• W2155116005 cites W2040288061 @default.
• W2155116005 cites W2041539580 @default.
• W2155116005 cites W2042412331 @default.
• W2155116005 cites W2045915905 @default.
• W2155116005 cites W2048988599 @default.
• W2155116005 cites W2060088029 @default.
• W2155116005 cites W2066686953 @default.
• W2155116005 cites W2081595143 @default.
• W2155116005 cites W2082456912 @default.
• W2155116005 cites W2089237353 @default.
• W2155116005 cites W2100330873 @default.
• W2155116005 cites W2101375237 @default.
• W2155116005 cites W2101965993 @default.
• W2155116005 cites W2103384599 @default.
• W2155116005 cites W2108187252 @default.
• W2155116005 cites W2113736505 @default.
• W2155116005 cites W2124346865 @default.
• W2155116005 cites W2131646711 @default.
• W2155116005 cites W2131871620 @default.
• W2155116005 cites W2132879755 @default.
• W2155116005 cites W2135474288 @default.
• W2155116005 cites W2137664573 @default.
• W2155116005 cites W2137736246 @default.
• W2155116005 cites W2139439820 @default.
• W2155116005 cites W2142633097 @default.
• W2155116005 cites W2144597774 @default.
• W2155116005 cites W2161937009 @default.
• W2155116005 cites W2166858952 @default.
• W2155116005 cites W2170737790 @default.
• W2155116005 cites W2255900330 @default.
• W2155116005 cites W2409716039 @default.
• W2155116005 cites W4239561605 @default.
• W2155116005 cites W4313309086 @default.
• W2155116005 cites W4367436136 @default.
• W2155116005 doi "https://doi.org/10.4049/jimmunol.165.12.7224" @default.
• W2155116005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11120855" @default.
• W2155116005 hasPublicationYear "2000" @default.
• W2155116005 type Work @default.
• W2155116005 sameAs 2155116005 @default.
• W2155116005 citedByCount "70" @default.
• W2155116005 countsByYear W21551160052012 @default.
• W2155116005 countsByYear W21551160052013 @default.
• W2155116005 countsByYear W21551160052014 @default.
• W2155116005 countsByYear W21551160052016 @default.
• W2155116005 countsByYear W21551160052017 @default.
• W2155116005 countsByYear W21551160052021 @default.
• W2155116005 countsByYear W21551160052022 @default.
• W2155116005 crossrefType "journal-article" @default.
• W2155116005 hasAuthorship W2155116005A5000219202 @default.
• W2155116005 hasAuthorship W2155116005A5006321692 @default.
• W2155116005 hasAuthorship W2155116005A5008452248 @default.
• W2155116005 hasAuthorship W2155116005A5012208330 @default.
• W2155116005 hasAuthorship W2155116005A5032808351 @default.
• W2155116005 hasAuthorship W2155116005A5033052914 @default.
• W2155116005 hasAuthorship W2155116005A5052511743 @default.
• W2155116005 hasAuthorship W2155116005A5064418813 @default.
• W2155116005 hasAuthorship W2155116005A5079322951 @default.
• W2155116005 hasBestOaLocation W21551160051 @default.

• next