Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155116729> ?p ?o ?g. }
- W2155116729 endingPage "117" @default.
- W2155116729 startingPage "103" @default.
- W2155116729 abstract "Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung scarring, short median survival, and limited therapeutic options, creating great need for new pharmacologic therapies. IPF is thought to result from repetitive environmental injury to the lung epithelium, in the context of aberrant host wound healing responses. Tissue responses to injury fundamentally involve reorganization of the actin cytoskeleton of participating cells, including epithelial cells, fibroblasts, endothelial cells, and macrophages. Actin filament assembly and actomyosin contraction are directed by the Rho-associated coiled-coil forming protein kinase (ROCK) family of serine/threonine kinases (ROCK1 and ROCK2). As would therefore be expected, lung ROCK activation has been demonstrated in humans with IPF and in animal models of this disease. ROCK inhibitors can prevent fibrosis in these models, and more importantly, induce the regression of already established fibrosis. Here we review ROCK structure and function, upstream activators and downstream targets of ROCKs in pulmonary fibrosis, contributions of ROCKs to profibrotic cellular responses to lung injury, ROCK inhibitors and their efficacy in animal models of pulmonary fibrosis, and potential toxicities of ROCK inhibitors in humans, as well as involvement of ROCKs in fibrosis in other organs. As we discuss, ROCK activation is required for multiple profibrotic responses, in the lung and multiple other organs, suggesting ROCK participation in fundamental pathways that contribute to the pathogenesis of a broad array of fibrotic diseases. Multiple lines of evidence therefore indicate that ROCK inhibition has great potential to be a powerful therapeutic tool in the treatment of fibrosis, both in the lung and beyond." @default.
- W2155116729 created "2016-06-24" @default.
- W2155116729 creator A5010397554 @default.
- W2155116729 creator A5018732153 @default.
- W2155116729 creator A5036590935 @default.
- W2155116729 date "2014-11-13" @default.
- W2155116729 modified "2023-10-13" @default.
- W2155116729 title "The Rho Kinases: Critical Mediators of Multiple Profibrotic Processes and Rational Targets for New Therapies for Pulmonary Fibrosis" @default.
- W2155116729 cites W111824599 @default.
- W2155116729 cites W1575754639 @default.
- W2155116729 cites W1597258706 @default.
- W2155116729 cites W1600691036 @default.
- W2155116729 cites W1606040269 @default.
- W2155116729 cites W1643035528 @default.
- W2155116729 cites W1966760994 @default.
- W2155116729 cites W1969049128 @default.
- W2155116729 cites W1971010914 @default.
- W2155116729 cites W1972875588 @default.
- W2155116729 cites W1976425440 @default.
- W2155116729 cites W1977919177 @default.
- W2155116729 cites W1977956981 @default.
- W2155116729 cites W1978532495 @default.
- W2155116729 cites W1980093700 @default.
- W2155116729 cites W1982121530 @default.
- W2155116729 cites W1982159478 @default.
- W2155116729 cites W1985502400 @default.
- W2155116729 cites W1985859986 @default.
- W2155116729 cites W1986886732 @default.
- W2155116729 cites W1987066724 @default.
- W2155116729 cites W1993379452 @default.
- W2155116729 cites W1995495646 @default.
- W2155116729 cites W1995592152 @default.
- W2155116729 cites W1995757732 @default.
- W2155116729 cites W1997087774 @default.
- W2155116729 cites W1998975199 @default.
- W2155116729 cites W2004107033 @default.
- W2155116729 cites W2008029604 @default.
- W2155116729 cites W2008683618 @default.
- W2155116729 cites W2011107835 @default.
- W2155116729 cites W2011379117 @default.
- W2155116729 cites W2013426785 @default.
- W2155116729 cites W2017946623 @default.
- W2155116729 cites W2018223916 @default.
- W2155116729 cites W2018809578 @default.
- W2155116729 cites W2019222060 @default.
- W2155116729 cites W2019431738 @default.
- W2155116729 cites W2024704335 @default.
- W2155116729 cites W2024904424 @default.
- W2155116729 cites W2025029681 @default.
- W2155116729 cites W2025299905 @default.
- W2155116729 cites W2025663530 @default.
- W2155116729 cites W2033055551 @default.
- W2155116729 cites W2033998652 @default.
- W2155116729 cites W2034338127 @default.
- W2155116729 cites W2036057310 @default.
- W2155116729 cites W2038607574 @default.
- W2155116729 cites W2040992047 @default.
- W2155116729 cites W2044478331 @default.
- W2155116729 cites W2045142779 @default.
- W2155116729 cites W2045730105 @default.
- W2155116729 cites W2046501504 @default.
- W2155116729 cites W2050552243 @default.
- W2155116729 cites W2052147002 @default.
- W2155116729 cites W2052750950 @default.
- W2155116729 cites W2052917153 @default.
- W2155116729 cites W2058357630 @default.
- W2155116729 cites W2061229883 @default.
- W2155116729 cites W2064574428 @default.
- W2155116729 cites W2067371230 @default.
- W2155116729 cites W2067577192 @default.
- W2155116729 cites W2068483215 @default.
- W2155116729 cites W2070821389 @default.
- W2155116729 cites W2071701870 @default.
- W2155116729 cites W2073353515 @default.
- W2155116729 cites W2075126241 @default.
- W2155116729 cites W2077269159 @default.
- W2155116729 cites W2077603983 @default.
- W2155116729 cites W2081245863 @default.
- W2155116729 cites W2081380910 @default.
- W2155116729 cites W2082837373 @default.
- W2155116729 cites W2083822658 @default.
- W2155116729 cites W2085162251 @default.
- W2155116729 cites W2090392605 @default.
- W2155116729 cites W2090640877 @default.
- W2155116729 cites W2092042066 @default.
- W2155116729 cites W2092427093 @default.
- W2155116729 cites W2095013780 @default.
- W2155116729 cites W2095095219 @default.
- W2155116729 cites W2097921546 @default.
- W2155116729 cites W2098305693 @default.
- W2155116729 cites W2099003712 @default.
- W2155116729 cites W2099486691 @default.
- W2155116729 cites W2099709490 @default.
- W2155116729 cites W2101072720 @default.
- W2155116729 cites W2103220804 @default.
- W2155116729 cites W2104778949 @default.
- W2155116729 cites W2106408170 @default.
- W2155116729 cites W2106514058 @default.