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- W2155116771 abstract "Oxidative stress in the heart of male rats fed on a vitamin A-deficient diet for three months from 21 days of age was evaluated. Vitamin A restriction produced subclinical plasma retinol concentration (0.7 μmol/l), negligible liver retinol stores and a significant decrease of heart retinol concentration, as determined by HPLC, compared with the control group receiving the same diet with 4000 IU of vitamin A (8 mg retinol as retinyl palmitate) per kg of diet. Vitamin A-deficient rats had lower body weight than control rats. No change in the heart weights was observed. In serum of rats fed the vitamin A-deficient diet the concentrations of thiobarbituric acid-reactive substances (TBARS) and reduced glutathione (GSH) increased by ∼65% and 60%, respectively, compared with those fed on the control diet. In hearts of vitamin A-deficient rats the concentration of TBARS and the glutathione peroxidase activity significantly increased. The activity of catalase decreased by ∼30%, while the superoxide dismutase did not change. Additionally, vitamin A-deficient rats showed lower heart concentrations of the trace elements selenium, manganese and chromium. Heart iron, copper and zinc concentrations were not affected. Vitamin A deprivation for 3 months decreased the plasma and heart retinol concentrations associated with changes in non-enzymatic and enzymatic antioxidant defense system components." @default.
- W2155116771 created "2016-06-24" @default.
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- W2155116771 date "2000-08-01" @default.
- W2155116771 modified "2023-10-17" @default.
- W2155116771 title "Vitamin a deficiency modifies antioxidant defenses and essential element contents in rat heart" @default.
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- W2155116771 doi "https://doi.org/10.1016/s0271-5317(00)00204-9" @default.
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