FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155117467> ?p ?o ?g. }

• W2155117467 endingPage "1344" @default.
• W2155117467 startingPage "1334" @default.
• W2155117467 abstract "ABSTRACT Laboratory-adapted (LA) macrophage-tropic (M-tropic) human immunodeficiency virus type 1 (HIV-1) isolates (e.g., HIV-1 Ba-L ) and low-passage primary (PR) isolates differed markedly in tropism for syngeneic neonatal monocytes, monocyte-derived macrophages (MDMs), and placental macrophages (PMs). Newly adherent neonatal monocytes and cultured PMs were highly refractory to infection with PR HIV-1 isolates yet were permissive for LA M-tropic isolates. Day 4 MDMs were also permissive for LA M-tropic isolates and additionally, were permissive for over half the PR isolates tested. Qualitative differences in PR HIV-1 infection of monocytes/MDMs could not be correlated with CD4 levels alone, and in all three cell types the block to PR HIV-1 strain replication preceded reverse transcription. Neonatal monocyte susceptibility to PR HIV-1 strains correlated with increasing CCR-5 expression during maturation. CCR-5 could not be detected on newly adherent (day 1) neonatal monocytes, in contrast to adult monocytes (H. Naif et al., J. Virol. 72:830–836, 1998), but was readily detectable after 4 to 7 days of culture. However, moderate CCR-5 mRNA levels were present in day 1 neonatal monocytes and remained constant during monocyte maturation. CCR-5 was not detectable on the surface of PMs, yet the receptor was present within permeabilized cells. Notably, two brain-derived PR HIV-1 isolates from a single patient, differing in their V3 loops, were discordant in their abilities to infect neonatal monocytes/MDMs and PMs, yet both isolates could infect newly adherent adult monocytes. Together these data strongly suggest that LA HIV-1 isolates are able to infect neonatal monocytes at earlier stages of maturation and lower-level expression of CCR-5 than PR isolates. The differences between neonatal and adult monocytes in susceptibility to PR isolates may also be related to the level of CCR-5 expression." @default.
• W2155117467 created "2016-06-24" @default.
• W2155117467 creator A5017667890 @default.
• W2155117467 creator A5018086400 @default.
• W2155117467 creator A5026553554 @default.
• W2155117467 creator A5063684941 @default.
• W2155117467 creator A5081568736 @default.
• W2155117467 date "1998-02-01" @default.
• W2155117467 modified "2023-10-01" @default.
• W2155117467 title "Differential Tropism and Chemokine Receptor Expression of Human Immunodeficiency Virus Type 1 in Neonatal Monocytes, Monocyte-Derived Macrophages, and Placental Macrophages" @default.
• W2155117467 cites W1481422886 @default.
• W2155117467 cites W1514857866 @default.
• W2155117467 cites W1567337111 @default.
• W2155117467 cites W1773346304 @default.
• W2155117467 cites W1940730177 @default.
• W2155117467 cites W1955239150 @default.
• W2155117467 cites W1963855922 @default.
• W2155117467 cites W1965019797 @default.
• W2155117467 cites W1968293205 @default.
• W2155117467 cites W1969899610 @default.
• W2155117467 cites W1971777539 @default.
• W2155117467 cites W1975258429 @default.
• W2155117467 cites W1981440980 @default.
• W2155117467 cites W1981644527 @default.
• W2155117467 cites W1982528951 @default.
• W2155117467 cites W1983466424 @default.
• W2155117467 cites W1986751634 @default.
• W2155117467 cites W1989035987 @default.
• W2155117467 cites W1989701896 @default.
• W2155117467 cites W1993296353 @default.
• W2155117467 cites W1996183144 @default.
• W2155117467 cites W1998990074 @default.
• W2155117467 cites W2009824933 @default.
• W2155117467 cites W2013522291 @default.
• W2155117467 cites W2014457629 @default.
• W2155117467 cites W2014828698 @default.
• W2155117467 cites W2017551575 @default.
• W2155117467 cites W2019508559 @default.
• W2155117467 cites W2026328689 @default.
• W2155117467 cites W2030017358 @default.
• W2155117467 cites W2030692398 @default.
• W2155117467 cites W2031211341 @default.
• W2155117467 cites W2032118018 @default.
• W2155117467 cites W2036679171 @default.
• W2155117467 cites W2037793240 @default.
• W2155117467 cites W2039456926 @default.
• W2155117467 cites W2047480444 @default.
• W2155117467 cites W2056313383 @default.
• W2155117467 cites W2057327797 @default.
• W2155117467 cites W2066274357 @default.
• W2155117467 cites W2069407559 @default.
• W2155117467 cites W2075416959 @default.
• W2155117467 cites W2082551424 @default.
• W2155117467 cites W2088874312 @default.
• W2155117467 cites W2092188498 @default.
• W2155117467 cites W2097202778 @default.
• W2155117467 cites W2097323140 @default.
• W2155117467 cites W2099768074 @default.
• W2155117467 cites W2099982660 @default.
• W2155117467 cites W2100267867 @default.
• W2155117467 cites W2107052849 @default.
• W2155117467 cites W2111105264 @default.
• W2155117467 cites W2112942312 @default.
• W2155117467 cites W2113736505 @default.
• W2155117467 cites W2114668630 @default.
• W2155117467 cites W2116720206 @default.
• W2155117467 cites W2119658622 @default.
• W2155117467 cites W2127501349 @default.
• W2155117467 cites W2142809896 @default.
• W2155117467 cites W2145656711 @default.
• W2155117467 cites W2150012700 @default.
• W2155117467 cites W2152003330 @default.
• W2155117467 cites W2156694786 @default.
• W2155117467 cites W2157418548 @default.
• W2155117467 cites W2167049427 @default.
• W2155117467 cites W2167906381 @default.
• W2155117467 cites W2188240263 @default.
• W2155117467 cites W2316970929 @default.
• W2155117467 cites W2331026432 @default.
• W2155117467 cites W2332434511 @default.
• W2155117467 cites W235887733 @default.
• W2155117467 cites W2414066980 @default.
• W2155117467 cites W4235080258 @default.
• W2155117467 cites W4246418227 @default.
• W2155117467 cites W4248096216 @default.
• W2155117467 cites W4293052483 @default.
• W2155117467 doi "https://doi.org/10.1128/jvi.72.2.1334-1344.1998" @default.
• W2155117467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/124612" @default.
• W2155117467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9445034" @default.
• W2155117467 hasPublicationYear "1998" @default.
• W2155117467 type Work @default.
• W2155117467 sameAs 2155117467 @default.
• W2155117467 citedByCount "78" @default.
• W2155117467 countsByYear W21551174672012 @default.
• W2155117467 countsByYear W21551174672014 @default.
• W2155117467 countsByYear W21551174672019 @default.
• W2155117467 countsByYear W21551174672020 @default.
• W2155117467 countsByYear W21551174672021 @default.

• next