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• W2155118851 abstract "Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 microg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin." @default.
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• W2155118851 date "2004-01-01" @default.
• W2155118851 modified "2023-09-29" @default.
• W2155118851 title "Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues" @default.
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• W2155118851 doi "https://doi.org/10.1016/j.bmcl.2003.09.086" @default.
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