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- W2155119291 abstract "In early recurrent herpetic lesions, CD4 T lymphocytes are the predominant infiltrating cells, and keratinocytes expressing major histocompatibility complex (MHC) class II antigens, induced by interferon-γ (IFN-γ), are the major site of herpes simplex virus (HSV)replication. IFN-γ pretreatment of human keratinocytes in vitro reduced MHC class I antigen down-regulation by HSV-1 infection and induced expression of HLA-DR that was unaltered by subsequent HSV-1 infection. Incubation of these infected keratinocytes with phosphonoacetic acid (PAA) almost completely inhibited expression of four major HSV glycoproteins, although expression of early proteins was not affected. Weak CD8 T lymphocyte cytotoxicity against IFN-γ-stimulated, HLA-DR-expressing HSV-1-infected keratinocytes was consistently directed to the immediate early/early proteins (all 9 patients tested) but against late proteins to a lesser degree (4/9 patients). However, CD4 T lymphocyte cytotoxicity was much greater and directed predominantly against late HSV-1 glycoproteins (all 9 subjects tested) in these cells." @default.
- W2155119291 created "2016-06-24" @default.
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- W2155119291 date "1996-01-01" @default.
- W2155119291 modified "2023-09-26" @default.
- W2155119291 title "Herpes Simplex Virus Protein Targets for CD4 and CD8 Lymphocyte Cytotoxicity in Cultured Epidermal Keratinocytes Treated with Interferon-γ" @default.
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- W2155119291 doi "https://doi.org/10.1093/infdis/173.1.7" @default.
- W2155119291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8537685" @default.
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