Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155120713> ?p ?o ?g. }
- W2155120713 endingPage "1635" @default.
- W2155120713 startingPage "1621" @default.
- W2155120713 abstract "DNA decatenation mediated by Topoisomerase II is required to separate the interlinked sister chromatids post-replication. SGS1, a yeast homolog of the human RecQ family of helicases interacts with Topoisomerase II and plays a role in chromosome segregation, but this functional interaction has yet to be identified in higher organisms. Here, we report a physical and functional interaction of Topoisomerase IIα with RECQL5, one of five mammalian RecQ helicases, during DNA replication. Direct interaction of RECQL5 with Topoisomerase IIα stimulates the decatenation activity of Topoisomerase IIα. Consistent with these observations, RECQL5 co-localizes with Topoisomerase IIα during S-phase of the cell cycle. Moreover, cells with stable depletions of RECQL5 display a slow proliferation rate, a G2/M cell cycle arrest and late S-phase cycling defects. Metaphase spreads generated from RECQL5-depleted cells exhibit undercondensed and entangled chromosomes. Further, RECQL5-depleted cells activate a G2/M checkpoint and undergo apoptosis. These phenotypes are similar to those observed when Topoisomerase II catalytic activity is inhibited. These results reveal an important role for RECQL5 in the maintenance of genomic stability and a new insight into the decatenation process." @default.
- W2155120713 created "2016-06-24" @default.
- W2155120713 creator A5017116006 @default.
- W2155120713 creator A5017796398 @default.
- W2155120713 creator A5030531956 @default.
- W2155120713 creator A5038249001 @default.
- W2155120713 creator A5046044982 @default.
- W2155120713 creator A5046296830 @default.
- W2155120713 creator A5076116016 @default.
- W2155120713 creator A5080766939 @default.
- W2155120713 creator A5083413299 @default.
- W2155120713 creator A5089917586 @default.
- W2155120713 date "2011-10-19" @default.
- W2155120713 modified "2023-09-27" @default.
- W2155120713 title "RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression" @default.
- W2155120713 cites W1498953001 @default.
- W2155120713 cites W1501231487 @default.
- W2155120713 cites W1557550609 @default.
- W2155120713 cites W1842513541 @default.
- W2155120713 cites W1868383104 @default.
- W2155120713 cites W1969679710 @default.
- W2155120713 cites W1970069044 @default.
- W2155120713 cites W1973552223 @default.
- W2155120713 cites W1974102739 @default.
- W2155120713 cites W1986077184 @default.
- W2155120713 cites W1987545732 @default.
- W2155120713 cites W1991908053 @default.
- W2155120713 cites W1993243592 @default.
- W2155120713 cites W1996873024 @default.
- W2155120713 cites W1997319030 @default.
- W2155120713 cites W2001193188 @default.
- W2155120713 cites W2003745942 @default.
- W2155120713 cites W2010056602 @default.
- W2155120713 cites W2012025542 @default.
- W2155120713 cites W2015378640 @default.
- W2155120713 cites W2016240319 @default.
- W2155120713 cites W2017592458 @default.
- W2155120713 cites W2018093390 @default.
- W2155120713 cites W2022166341 @default.
- W2155120713 cites W2030639168 @default.
- W2155120713 cites W2035692319 @default.
- W2155120713 cites W2037798154 @default.
- W2155120713 cites W2039674107 @default.
- W2155120713 cites W2041840396 @default.
- W2155120713 cites W2045464664 @default.
- W2155120713 cites W2057431887 @default.
- W2155120713 cites W2058911936 @default.
- W2155120713 cites W2060625057 @default.
- W2155120713 cites W2060672912 @default.
- W2155120713 cites W2062101590 @default.
- W2155120713 cites W2062633116 @default.
- W2155120713 cites W2073483575 @default.
- W2155120713 cites W2079213534 @default.
- W2155120713 cites W2079613111 @default.
- W2155120713 cites W2082213805 @default.
- W2155120713 cites W2087746152 @default.
- W2155120713 cites W2106320156 @default.
- W2155120713 cites W2116031228 @default.
- W2155120713 cites W2117236768 @default.
- W2155120713 cites W2122669551 @default.
- W2155120713 cites W2123235480 @default.
- W2155120713 cites W2123557271 @default.
- W2155120713 cites W2124624490 @default.
- W2155120713 cites W2127550258 @default.
- W2155120713 cites W2131980596 @default.
- W2155120713 cites W2133369866 @default.
- W2155120713 cites W2133839705 @default.
- W2155120713 cites W2134480031 @default.
- W2155120713 cites W2137889806 @default.
- W2155120713 cites W2156817507 @default.
- W2155120713 cites W2160948762 @default.
- W2155120713 cites W2161217323 @default.
- W2155120713 cites W2170235750 @default.
- W2155120713 cites W4232173461 @default.
- W2155120713 cites W4377834668 @default.
- W2155120713 doi "https://doi.org/10.1093/nar/gkr844" @default.
- W2155120713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3287182" @default.
- W2155120713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22013166" @default.
- W2155120713 hasPublicationYear "2011" @default.
- W2155120713 type Work @default.
- W2155120713 sameAs 2155120713 @default.
- W2155120713 citedByCount "41" @default.
- W2155120713 countsByYear W21551207132012 @default.
- W2155120713 countsByYear W21551207132013 @default.
- W2155120713 countsByYear W21551207132014 @default.
- W2155120713 countsByYear W21551207132015 @default.
- W2155120713 countsByYear W21551207132016 @default.
- W2155120713 countsByYear W21551207132017 @default.
- W2155120713 countsByYear W21551207132018 @default.
- W2155120713 countsByYear W21551207132019 @default.
- W2155120713 countsByYear W21551207132020 @default.
- W2155120713 countsByYear W21551207132021 @default.
- W2155120713 countsByYear W21551207132022 @default.
- W2155120713 countsByYear W21551207132023 @default.
- W2155120713 crossrefType "journal-article" @default.
- W2155120713 hasAuthorship W2155120713A5017116006 @default.
- W2155120713 hasAuthorship W2155120713A5017796398 @default.
- W2155120713 hasAuthorship W2155120713A5030531956 @default.