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- W2155121115 abstract "We have tested the possible association of HLA-DQB and HLA-DPB alleles with Graves'thyrotoxicosis, with or without severe ophthalmopathy, by polymerase chain amplification of genomic DNA and allele-specific oligonucleotide probing. There was no significantly abnormal distribution of DQB alleles compared to 50 control subjects except for a reduced prevalence of DQw 3.1 in the Graves'patients with severe ophthalmopathy (x2= 6.23, P < 0.02). HLA-DPB 2.1/8 was found in only 1 of 40 of these patients compared with 15 of the controls (x2= 11.49, P <0-001). Ten of 48 patients with Graves'disease but without clinically significant eye involvement were HLA-DPB 2.1/8 positive, not significantly different from controls, but significantly different from the ophthalmopathy group (x2= 6.70, P < 0.01). The other DPB alleles in both groups of Graves'disease patients were the same as controls. These results suggest that HLA-DPB 2.1/8 may confer a protective effect in Graves'disease with respect to ophthalmopathy." @default.
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- W2155121115 date "1990-07-01" @default.
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- W2155121115 title "ANALYSIS OF HLA-DQB AND HLA-DPB ALLELES IN Graves'DISEASE BY OLIGONUCLEOTIDE PROBING OF ENZYMATICALLY AMPLIFIED DNA" @default.
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- W2155121115 doi "https://doi.org/10.1111/j.1365-2265.1990.tb00466.x" @default.
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