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• W2155122941 abstract "The effect of supplementing antioxidants, ascorbic acid (AA) and dimethyl sulfoxide (DMSO) following diminazene administration in T. brucei infected rats was studied by assessing weight gain, survivability, parasitemia and plasma protein levels. The fi rst group (I) of fi ve rats was uninfected. Four additional groups of fi ve rats per group were infected with T. brucei. One of the infected groups (II) was left untreated while the remaining three groups (III, IV and V) received 3.5 mg.kg -1 of diminazene aceturate intramuscularly. One of the three diminazene treated groups (III) received no supplements, while the remaining two received daily oral supplements of 0.5 g.kg-1 DMSO (group IV) and 100 mg.kg-1 AA (group V). Antioxidant supplements were initiated on the day of diminazene treatment. The daily requirements of antioxidants were dispensed in small volumes of drinking water. Fresh water was given to the animals after the drug solutions were exhausted. Overall weight gain in the groups were 208.35% (uninfected), 25.86% (infected; untreated), 208.71% (diminazene/DMSO), 155.94% (diminazene alone) and 166.75% (diminazene/AA). Weight changes were inversely related to parasitemia level in the infected, untreated group. Survival rates were 100% (uninfected); 0% (infected, untreated); 0% (diminazene alone), 25% (diminazene/DMSO) and 80% (diminazene/AA). By day 21 post treatment, parasites re-appeared in all treated groups with the diminazene group recording the highest parasitemia (2.51×10 8" @default.
• W2155122941 created "2016-06-24" @default.
• W2155122941 creator A5057297489 @default.
• W2155122941 date "2012-09-11" @default.
• W2155122941 modified "2023-09-26" @default.
• W2155122941 title "The effect of supplemental antioxidants vitamin C and dimethyl sulfoxide on weight gain and survival in T. brucei infected and diminazene treated rats." @default.
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