FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155125894> ?p ?o ?g. }

• W2155125894 endingPage "266" @default.
• W2155125894 startingPage "259" @default.
• W2155125894 abstract "Previously we demonstrated that treatment of mice with either UVB radiation or supernatants derived from UVB-irradiated PAM 212 keratinocytes decreased the induction of the delayed-type hypersensitivity (DTH) response to Mycobacterium bovis bacillus Calmette-Guerin (BCG), impaired the clearance of bacteria from their lymphoid organs and also altered macrophage functions. In order to characterize the cytokines involved in these phenomena, UV-irradiated mice were injected with antibodies to interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-beta 1), or tumor necrosis factor-alpha (TNF-alpha). Injection of UVB-irradiated mice with anti-IL-10 immediately after UV irradiation restored the DTH response and reversed the UV-induced inhibition of bacterial clearance. Injection of UV-irradiated mice with anti-TGF-beta only partially restored the DTH response although it allowed a better clearance of BCG than injection of mice with the control antibody. In contrast, injection of anti-TNF-alpha did not affect the UVB-induced suppression of DTH or impaired bacterial clearance. Similarly, the ability of macrophages to phagocytose BCG and kill the intracellular organisms was restored to almost normal levels after injecting UV-irradiated mice with antibodies specific for IL-10 or TGF-beta. Injection of mice with either recombinant IL-10 or TGF-beta mimicked the effect of whole-body UV irradiation on immune function. These results suggest that IL-10 has a major role in UV-induced suppression of both DTH to BCG and impairment in the clearance of bacteria and that TGF-beta has a more significant role in blocking bacterial clearance. Furthermore, these cytokines seem to modulate immune responses by altering macrophage functions in UVB-irradiated mice." @default.
• W2155125894 created "2016-06-24" @default.
• W2155125894 creator A5025910593 @default.
• W2155125894 creator A5038680484 @default.
• W2155125894 creator A5044847814 @default.
• W2155125894 creator A5067291177 @default.
• W2155125894 creator A5079706709 @default.
• W2155125894 date "1996-08-01" @default.
• W2155125894 modified "2023-10-16" @default.
• W2155125894 title "Mechanism of UVB-Induced Suppression of the Immune Response to Mycobacterium bovis Bacillus Calmette-Guerin: Role of Cytokines on Macrophage Function" @default.
• W2155125894 cites W1487729161 @default.
• W2155125894 cites W1516024856 @default.
• W2155125894 cites W1575945829 @default.
• W2155125894 cites W1578877546 @default.
• W2155125894 cites W1755853394 @default.
• W2155125894 cites W1796759324 @default.
• W2155125894 cites W1840508886 @default.
• W2155125894 cites W1853090825 @default.
• W2155125894 cites W1856702249 @default.
• W2155125894 cites W1862937233 @default.
• W2155125894 cites W1913686053 @default.
• W2155125894 cites W1931057000 @default.
• W2155125894 cites W1941022772 @default.
• W2155125894 cites W1943019381 @default.
• W2155125894 cites W1966875481 @default.
• W2155125894 cites W1975315742 @default.
• W2155125894 cites W1976213001 @default.
• W2155125894 cites W1980816578 @default.
• W2155125894 cites W1995327035 @default.
• W2155125894 cites W2000137099 @default.
• W2155125894 cites W2018172250 @default.
• W2155125894 cites W2025001062 @default.
• W2155125894 cites W2029897352 @default.
• W2155125894 cites W2054941139 @default.
• W2155125894 cites W2058065574 @default.
• W2155125894 cites W2058397355 @default.
• W2155125894 cites W2062300361 @default.
• W2155125894 cites W2065871536 @default.
• W2155125894 cites W2067632818 @default.
• W2155125894 cites W2072059088 @default.
• W2155125894 cites W2083952857 @default.
• W2155125894 cites W2093956513 @default.
• W2155125894 cites W2123064561 @default.
• W2155125894 cites W2127735574 @default.
• W2155125894 cites W2132578266 @default.
• W2155125894 cites W2146600581 @default.
• W2155125894 cites W2158035277 @default.
• W2155125894 cites W2162763987 @default.
• W2155125894 cites W2172009888 @default.
• W2155125894 cites W2185105583 @default.
• W2155125894 cites W2318943984 @default.
• W2155125894 cites W246617125 @default.
• W2155125894 doi "https://doi.org/10.1111/j.1751-1097.1996.tb02455.x" @default.
• W2155125894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8760565" @default.
• W2155125894 hasPublicationYear "1996" @default.
• W2155125894 type Work @default.
• W2155125894 sameAs 2155125894 @default.
• W2155125894 citedByCount "22" @default.
• W2155125894 countsByYear W21551258942012 @default.
• W2155125894 countsByYear W21551258942016 @default.
• W2155125894 countsByYear W21551258942017 @default.
• W2155125894 crossrefType "journal-article" @default.
• W2155125894 hasAuthorship W2155125894A5025910593 @default.
• W2155125894 hasAuthorship W2155125894A5038680484 @default.
• W2155125894 hasAuthorship W2155125894A5044847814 @default.
• W2155125894 hasAuthorship W2155125894A5067291177 @default.
• W2155125894 hasAuthorship W2155125894A5079706709 @default.
• W2155125894 hasConcept C142724271 @default.
• W2155125894 hasConcept C153911025 @default.
• W2155125894 hasConcept C159654299 @default.
• W2155125894 hasConcept C17991360 @default.
• W2155125894 hasConcept C185592680 @default.
• W2155125894 hasConcept C202751555 @default.
• W2155125894 hasConcept C203014093 @default.
• W2155125894 hasConcept C2777975735 @default.
• W2155125894 hasConcept C2778497218 @default.
• W2155125894 hasConcept C2778690821 @default.
• W2155125894 hasConcept C2779244956 @default.
• W2155125894 hasConcept C2781069245 @default.
• W2155125894 hasConcept C55493867 @default.
• W2155125894 hasConcept C71924100 @default.
• W2155125894 hasConcept C86803240 @default.
• W2155125894 hasConcept C8891405 @default.
• W2155125894 hasConcept C89423630 @default.
• W2155125894 hasConceptScore W2155125894C142724271 @default.
• W2155125894 hasConceptScore W2155125894C153911025 @default.
• W2155125894 hasConceptScore W2155125894C159654299 @default.
• W2155125894 hasConceptScore W2155125894C17991360 @default.
• W2155125894 hasConceptScore W2155125894C185592680 @default.
• W2155125894 hasConceptScore W2155125894C202751555 @default.
• W2155125894 hasConceptScore W2155125894C203014093 @default.
• W2155125894 hasConceptScore W2155125894C2777975735 @default.
• W2155125894 hasConceptScore W2155125894C2778497218 @default.
• W2155125894 hasConceptScore W2155125894C2778690821 @default.
• W2155125894 hasConceptScore W2155125894C2779244956 @default.
• W2155125894 hasConceptScore W2155125894C2781069245 @default.
• W2155125894 hasConceptScore W2155125894C55493867 @default.
• W2155125894 hasConceptScore W2155125894C71924100 @default.

• next