FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155127310> ?p ?o ?g. }

• W2155127310 endingPage "377" @default.
• W2155127310 startingPage "369" @default.
• W2155127310 abstract "The TSH receptor (TSHR) is the critical target for antibody production in Graves' disease (GD). Insulin-like growth factor 1 receptor (IGF1R) has been proposed as a second autoantigen in complications of GD such as orbitopathy. We attempted to induce orbital tissue remodeling in mice undergoing immunizations with plasmids encoding TSHR and IGF1R delivered by in vivo skeletal muscle electroporation, a procedure known to give a sustained, long-term antibody response. Female BALB/c mice were challenged with TSHR A-subunit or IGF1Rα subunit plasmid by injection and electroporation. Mice challenged with TSHR A-subunit plasmid resulted in high frequency (75%) of hyperthyroidism and thyroid-stimulating antibodies. But strikingly, immunization with TSHR A-subunit plasmid also elicited antibody to IGF1Rα subunit. Mice challenged in the same manner with IGF1Rα subunit plasmid produced strong antibody responses to IGF1R, but did not undergo any changes in phenotype. Simultaneous challenge by double antigen immunization with the two plasmids in distant anatomical sites reduced the incidence of hyperthyroidism, potentially as a consequence of antigenic competition. Thyroid glands from the TSHR A-subunit plasmid-challenged group were enlarged with patchy microscopic infiltrates. Histological analysis of the orbital tissues demonstrated moderate connective tissue fibrosis and deposition of Masson's trichrome staining material. Our findings imply that immunization with TSHR A-subunit plasmid leads to generation of IGF1R antibodies, which together with thyroid-stimulating antibodies may precipitate remodeling of orbital tissue, raising our understanding of its close association with GD." @default.
• W2155127310 created "2016-06-24" @default.
• W2155127310 creator A5027255737 @default.
• W2155127310 creator A5038476807 @default.
• W2155127310 creator A5071903220 @default.
• W2155127310 creator A5076860341 @default.
• W2155127310 creator A5077112559 @default.
• W2155127310 creator A5081011433 @default.
• W2155127310 date "2011-06-29" @default.
• W2155127310 modified "2023-09-27" @default.
• W2155127310 title "Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA" @default.
• W2155127310 cites W1524871440 @default.
• W2155127310 cites W1656911289 @default.
• W2155127310 cites W1930521840 @default.
• W2155127310 cites W1963637896 @default.
• W2155127310 cites W1965800980 @default.
• W2155127310 cites W1989599222 @default.
• W2155127310 cites W1992997083 @default.
• W2155127310 cites W1993047784 @default.
• W2155127310 cites W1994040482 @default.
• W2155127310 cites W2000026315 @default.
• W2155127310 cites W2003608014 @default.
• W2155127310 cites W2008704676 @default.
• W2155127310 cites W2019000543 @default.
• W2155127310 cites W2024029731 @default.
• W2155127310 cites W2034161190 @default.
• W2155127310 cites W2043212719 @default.
• W2155127310 cites W2050500219 @default.
• W2155127310 cites W2063476700 @default.
• W2155127310 cites W2067600438 @default.
• W2155127310 cites W2070992980 @default.
• W2155127310 cites W2075154147 @default.
• W2155127310 cites W2094877916 @default.
• W2155127310 cites W2115348768 @default.
• W2155127310 cites W2137390873 @default.
• W2155127310 cites W2145497832 @default.
• W2155127310 cites W2151135812 @default.
• W2155127310 cites W2152255652 @default.
• W2155127310 cites W2154999896 @default.
• W2155127310 cites W2160499822 @default.
• W2155127310 cites W2475002689 @default.
• W2155127310 cites W4240137178 @default.
• W2155127310 cites W4248519364 @default.
• W2155127310 cites W85067608 @default.
• W2155127310 doi "https://doi.org/10.1530/joe-11-0162" @default.
• W2155127310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3152291" @default.
• W2155127310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21715431" @default.
• W2155127310 hasPublicationYear "2011" @default.
• W2155127310 type Work @default.
• W2155127310 sameAs 2155127310 @default.
• W2155127310 citedByCount "60" @default.
• W2155127310 countsByYear W21551273102012 @default.
• W2155127310 countsByYear W21551273102013 @default.
• W2155127310 countsByYear W21551273102014 @default.
• W2155127310 countsByYear W21551273102015 @default.
• W2155127310 countsByYear W21551273102016 @default.
• W2155127310 countsByYear W21551273102017 @default.
• W2155127310 countsByYear W21551273102018 @default.
• W2155127310 countsByYear W21551273102019 @default.
• W2155127310 countsByYear W21551273102020 @default.
• W2155127310 countsByYear W21551273102021 @default.
• W2155127310 countsByYear W21551273102022 @default.
• W2155127310 countsByYear W21551273102023 @default.
• W2155127310 crossrefType "journal-article" @default.
• W2155127310 hasAuthorship W2155127310A5027255737 @default.
• W2155127310 hasAuthorship W2155127310A5038476807 @default.
• W2155127310 hasAuthorship W2155127310A5071903220 @default.
• W2155127310 hasAuthorship W2155127310A5076860341 @default.
• W2155127310 hasAuthorship W2155127310A5077112559 @default.
• W2155127310 hasAuthorship W2155127310A5081011433 @default.
• W2155127310 hasBestOaLocation W21551273101 @default.
• W2155127310 hasConcept C126322002 @default.
• W2155127310 hasConcept C134018914 @default.
• W2155127310 hasConcept C144174609 @default.
• W2155127310 hasConcept C147483822 @default.
• W2155127310 hasConcept C153911025 @default.
• W2155127310 hasConcept C159654299 @default.
• W2155127310 hasConcept C170493617 @default.
• W2155127310 hasConcept C203014093 @default.
• W2155127310 hasConcept C2775960820 @default.
• W2155127310 hasConcept C2776652619 @default.
• W2155127310 hasConcept C2777608072 @default.
• W2155127310 hasConcept C526584372 @default.
• W2155127310 hasConcept C71924100 @default.
• W2155127310 hasConcept C86803240 @default.
• W2155127310 hasConceptScore W2155127310C126322002 @default.
• W2155127310 hasConceptScore W2155127310C134018914 @default.
• W2155127310 hasConceptScore W2155127310C144174609 @default.
• W2155127310 hasConceptScore W2155127310C147483822 @default.
• W2155127310 hasConceptScore W2155127310C153911025 @default.
• W2155127310 hasConceptScore W2155127310C159654299 @default.
• W2155127310 hasConceptScore W2155127310C170493617 @default.
• W2155127310 hasConceptScore W2155127310C203014093 @default.
• W2155127310 hasConceptScore W2155127310C2775960820 @default.
• W2155127310 hasConceptScore W2155127310C2776652619 @default.
• W2155127310 hasConceptScore W2155127310C2777608072 @default.
• W2155127310 hasConceptScore W2155127310C526584372 @default.
• W2155127310 hasConceptScore W2155127310C71924100 @default.

• next