FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155128976> ?p ?o ?g. }

• W2155128976 abstract "This thesis deals with the mathematical modeling of endocrinological networks that are underlying the female hormone cycle. These networks consist of a variety of biological mechanisms in different parts of the organism. Their interaction leads to periodic changes of various substances that are necessary for reproduction. In every cycle, hormones are secreted from the hypothalamic-pituitary-gonadal axis into the bloodstream, where they distribute and influence several functions in the body. Their most important task in reproduction is to regulate processes in the ovaries, where follicles and corpus luteum develop. These produce steroids that are released into the blood and from therein regulate the processes in the hypothalamic-pituitary-gonadal axis. The hormonal cycle is thus a result of a large feedback loop, whose self-regulation is a complex interplay of multiple components. For the modeling of these processes, a high abstraction level is required, which can be realized by various modeling approaches. In this work, some of these approaches are implemented. The first step in all approaches is the representation of the most important mechanisms in a flowchart. In the next step, this can be implemented as a system of ordinary differential equations using Hill functions, as a piecewise defined affine differential equation model, or directly as a purely regulatory model. Using this approach, a differential equation model for the hormonal cycle of cows is developed. This is compared with a more advanced model of the menstrual cycle in humans. Both models are validated by comparing simulations with measured values, and by studying external influences such as drug administration. For the example of the bovine estrous cycle, continuous analysis methods are used to investigate stability, follicular wave patterns, and robustness with respect to parameter perturbations. Furthermore, the model is substantially reduced while preserving the main simulation results. To take a look at alternative modeling approaches, corresponding discrete models are derived, exemplified for the bovine model. For a piecewise affine version of the model, parameter constraints for the continuous model are calculated. Stability is analyzed globally for a purely discrete model. In addition, core discrete models are derived, which retain the dynamic properties of the original model." @default.
• W2155128976 created "2016-06-24" @default.
• W2155128976 creator A5080418124 @default.
• W2155128976 date "2014-01-01" @default.
• W2155128976 modified "2023-09-24" @default.
• W2155128976 title "Numerical and Discrete Modeling of Reproductive Endocrinological Networks" @default.
• W2155128976 cites W1513897826 @default.
• W2155128976 cites W1535653284 @default.
• W2155128976 cites W15359178 @default.
• W2155128976 cites W1542467604 @default.
• W2155128976 cites W1544097513 @default.
• W2155128976 cites W154417448 @default.
• W2155128976 cites W1581071628 @default.
• W2155128976 cites W1586111760 @default.
• W2155128976 cites W1592141884 @default.
• W2155128976 cites W1712093580 @default.
• W2155128976 cites W1786929561 @default.
• W2155128976 cites W1794811791 @default.
• W2155128976 cites W1912998182 @default.
• W2155128976 cites W1963672278 @default.
• W2155128976 cites W1966980186 @default.
• W2155128976 cites W1968352112 @default.
• W2155128976 cites W1969107279 @default.
• W2155128976 cites W1970279487 @default.
• W2155128976 cites W1970535739 @default.
• W2155128976 cites W1973197730 @default.
• W2155128976 cites W1975400348 @default.
• W2155128976 cites W1977675996 @default.
• W2155128976 cites W1983852339 @default.
• W2155128976 cites W1986040959 @default.
• W2155128976 cites W1987633004 @default.
• W2155128976 cites W1989284002 @default.
• W2155128976 cites W1989839419 @default.
• W2155128976 cites W1989888144 @default.
• W2155128976 cites W1991825810 @default.
• W2155128976 cites W1995173236 @default.
• W2155128976 cites W1999987326 @default.
• W2155128976 cites W2001289891 @default.
• W2155128976 cites W2002071939 @default.
• W2155128976 cites W2003975080 @default.
• W2155128976 cites W2006922586 @default.
• W2155128976 cites W2007100691 @default.
• W2155128976 cites W2007102707 @default.
• W2155128976 cites W2010023724 @default.
• W2155128976 cites W2014544943 @default.
• W2155128976 cites W2015197603 @default.
• W2155128976 cites W2015441806 @default.
• W2155128976 cites W2018713870 @default.
• W2155128976 cites W2024876925 @default.
• W2155128976 cites W2025144645 @default.
• W2155128976 cites W2028244876 @default.
• W2155128976 cites W2028266223 @default.
• W2155128976 cites W2028564737 @default.
• W2155128976 cites W2030663899 @default.
• W2155128976 cites W2030849950 @default.
• W2155128976 cites W2031369606 @default.
• W2155128976 cites W2034427531 @default.
• W2155128976 cites W2035254745 @default.
• W2155128976 cites W2036739122 @default.
• W2155128976 cites W2037663176 @default.
• W2155128976 cites W2040498452 @default.
• W2155128976 cites W2040890176 @default.
• W2155128976 cites W2045966925 @default.
• W2155128976 cites W2046538693 @default.
• W2155128976 cites W2048690575 @default.
• W2155128976 cites W2050584501 @default.
• W2155128976 cites W2058221907 @default.
• W2155128976 cites W2059498062 @default.
• W2155128976 cites W2060515743 @default.
• W2155128976 cites W2062851852 @default.
• W2155128976 cites W2063498185 @default.
• W2155128976 cites W2064382733 @default.
• W2155128976 cites W2068607511 @default.
• W2155128976 cites W2071442003 @default.
• W2155128976 cites W2075860102 @default.
• W2155128976 cites W2076127338 @default.
• W2155128976 cites W2077649959 @default.
• W2155128976 cites W2077665464 @default.
• W2155128976 cites W2077974241 @default.
• W2155128976 cites W2078333049 @default.
• W2155128976 cites W2084200600 @default.
• W2155128976 cites W2085318565 @default.
• W2155128976 cites W2087901888 @default.
• W2155128976 cites W2092342606 @default.
• W2155128976 cites W2093864213 @default.
• W2155128976 cites W2094369576 @default.
• W2155128976 cites W2094808812 @default.
• W2155128976 cites W2099481678 @default.
• W2155128976 cites W2102277847 @default.
• W2155128976 cites W2103227807 @default.
• W2155128976 cites W2104015502 @default.
• W2155128976 cites W2104075601 @default.
• W2155128976 cites W2106275916 @default.
• W2155128976 cites W2106296634 @default.
• W2155128976 cites W2106454249 @default.
• W2155128976 cites W2106525152 @default.
• W2155128976 cites W2107156496 @default.
• W2155128976 cites W2107208446 @default.
• W2155128976 cites W2110207228 @default.
• W2155128976 cites W2111120894 @default.

• next