FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155134319> ?p ?o ?g. }

• W2155134319 endingPage "1016.e4" @default.
• W2155134319 startingPage "1006" @default.
• W2155134319 abstract "Background & AimsAltered gastrointestinal motility is associated with significant morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis. We examined the roles of TLR4 signaling in survival of enteric neurons and gastrointestinal motility.MethodsWe assessed changes in intestinal motility by assessing stool frequency, bead expulsion, and isometric muscle recordings of colonic longitudinal muscle strips from mice that do not express TLR4 (Tlr4Lps-d or TLR4−/−) or Myd88 (Myd88−/−), in wild-type germ-free mice or wild-type mice depleted of the microbiota, and in mice with neural crest-specific deletion of Myd88 (Wnt1Cre+/−/Myd88fl/fl). We studied the effects of the TLR4 agonist lipopolysaccharide (LPS) on survival of cultured, immortalized fetal enteric neurons and enteric neuronal cells isolated from wild-type and Tlr4Lps-d mice at embryonic day 13.5.ResultsThere was a significant delay in gastrointestinal motility and reduced numbers of nitrergic neurons in TLR4Lps-d, TLR4−/−, and Myd88−/− mice compared with wild-type mice. A similar phenotype was observed in germ-free mice, mice depleted of intestinal microbiota, and Wnt1Cre+/−/Myd88fl/fl mice. Incubation of enteric neuronal cells with LPS led to activation of the transcription factor nuclear factor (NF)-κB and increased cell survival.ConclusionsInteractions between enteric neurons and microbes increases neuron survival and gastrointestinal motility in mice. LPS activation of TLR4 and NF-κB appears to promote survival of enteric neurons. Factors that regulate TLR4 signaling in neurons might be developed to alter gastrointestinal motility. Altered gastrointestinal motility is associated with significant morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis. We examined the roles of TLR4 signaling in survival of enteric neurons and gastrointestinal motility. We assessed changes in intestinal motility by assessing stool frequency, bead expulsion, and isometric muscle recordings of colonic longitudinal muscle strips from mice that do not express TLR4 (Tlr4Lps-d or TLR4−/−) or Myd88 (Myd88−/−), in wild-type germ-free mice or wild-type mice depleted of the microbiota, and in mice with neural crest-specific deletion of Myd88 (Wnt1Cre+/−/Myd88fl/fl). We studied the effects of the TLR4 agonist lipopolysaccharide (LPS) on survival of cultured, immortalized fetal enteric neurons and enteric neuronal cells isolated from wild-type and Tlr4Lps-d mice at embryonic day 13.5. There was a significant delay in gastrointestinal motility and reduced numbers of nitrergic neurons in TLR4Lps-d, TLR4−/−, and Myd88−/− mice compared with wild-type mice. A similar phenotype was observed in germ-free mice, mice depleted of intestinal microbiota, and Wnt1Cre+/−/Myd88fl/fl mice. Incubation of enteric neuronal cells with LPS led to activation of the transcription factor nuclear factor (NF)-κB and increased cell survival. Interactions between enteric neurons and microbes increases neuron survival and gastrointestinal motility in mice. LPS activation of TLR4 and NF-κB appears to promote survival of enteric neurons. Factors that regulate TLR4 signaling in neurons might be developed to alter gastrointestinal motility." @default.
• W2155134319 created "2016-06-24" @default.
• W2155134319 creator A5010433764 @default.
• W2155134319 creator A5012188262 @default.
• W2155134319 creator A5019350885 @default.
• W2155134319 creator A5074874098 @default.
• W2155134319 creator A5091361579 @default.
• W2155134319 date "2012-10-01" @default.
• W2155134319 modified "2023-10-18" @default.
• W2155134319 title "Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling" @default.
• W2155134319 cites W1483162601 @default.
• W2155134319 cites W1487368140 @default.
• W2155134319 cites W1582832380 @default.
• W2155134319 cites W1589191320 @default.
• W2155134319 cites W1591153814 @default.
• W2155134319 cites W1607438626 @default.
• W2155134319 cites W1901598508 @default.
• W2155134319 cites W1976010325 @default.
• W2155134319 cites W1982170042 @default.
• W2155134319 cites W1986852617 @default.
• W2155134319 cites W1988178045 @default.
• W2155134319 cites W1992780204 @default.
• W2155134319 cites W1993697908 @default.
• W2155134319 cites W2000547390 @default.
• W2155134319 cites W2003426511 @default.
• W2155134319 cites W2004740947 @default.
• W2155134319 cites W2007576700 @default.
• W2155134319 cites W2008012961 @default.
• W2155134319 cites W2010801497 @default.
• W2155134319 cites W2032401280 @default.
• W2155134319 cites W2033902419 @default.
• W2155134319 cites W2038418093 @default.
• W2155134319 cites W2041136224 @default.
• W2155134319 cites W2045581442 @default.
• W2155134319 cites W2081133644 @default.
• W2155134319 cites W2083089709 @default.
• W2155134319 cites W2091080691 @default.
• W2155134319 cites W2112454216 @default.
• W2155134319 cites W2112663559 @default.
• W2155134319 cites W2123594750 @default.
• W2155134319 cites W2134098291 @default.
• W2155134319 cites W2134928825 @default.
• W2155134319 cites W2144679012 @default.
• W2155134319 cites W2153312234 @default.
• W2155134319 cites W2156234524 @default.
• W2155134319 cites W2160516610 @default.
• W2155134319 cites W2161746051 @default.
• W2155134319 doi "https://doi.org/10.1053/j.gastro.2012.06.034" @default.
• W2155134319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3458182" @default.
• W2155134319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22732731" @default.
• W2155134319 hasPublicationYear "2012" @default.
• W2155134319 type Work @default.
• W2155134319 sameAs 2155134319 @default.
• W2155134319 citedByCount "289" @default.
• W2155134319 countsByYear W21551343192013 @default.
• W2155134319 countsByYear W21551343192014 @default.
• W2155134319 countsByYear W21551343192015 @default.
• W2155134319 countsByYear W21551343192016 @default.
• W2155134319 countsByYear W21551343192017 @default.
• W2155134319 countsByYear W21551343192018 @default.
• W2155134319 countsByYear W21551343192019 @default.
• W2155134319 countsByYear W21551343192020 @default.
• W2155134319 countsByYear W21551343192021 @default.
• W2155134319 countsByYear W21551343192022 @default.
• W2155134319 countsByYear W21551343192023 @default.
• W2155134319 crossrefType "journal-article" @default.
• W2155134319 hasAuthorship W2155134319A5010433764 @default.
• W2155134319 hasAuthorship W2155134319A5012188262 @default.
• W2155134319 hasAuthorship W2155134319A5019350885 @default.
• W2155134319 hasAuthorship W2155134319A5074874098 @default.
• W2155134319 hasAuthorship W2155134319A5091361579 @default.
• W2155134319 hasBestOaLocation W21551343191 @default.
• W2155134319 hasConcept C126322002 @default.
• W2155134319 hasConcept C134018914 @default.
• W2155134319 hasConcept C136449434 @default.
• W2155134319 hasConcept C170493617 @default.
• W2155134319 hasConcept C203014093 @default.
• W2155134319 hasConcept C2776070231 @default.
• W2155134319 hasConcept C2776709828 @default.
• W2155134319 hasConcept C2777439022 @default.
• W2155134319 hasConcept C2778754761 @default.
• W2155134319 hasConcept C2778938600 @default.
• W2155134319 hasConcept C2780512811 @default.
• W2155134319 hasConcept C55493867 @default.
• W2155134319 hasConcept C58207958 @default.
• W2155134319 hasConcept C62478195 @default.
• W2155134319 hasConcept C71924100 @default.
• W2155134319 hasConcept C86803240 @default.
• W2155134319 hasConcept C95444343 @default.
• W2155134319 hasConceptScore W2155134319C126322002 @default.
• W2155134319 hasConceptScore W2155134319C134018914 @default.
• W2155134319 hasConceptScore W2155134319C136449434 @default.
• W2155134319 hasConceptScore W2155134319C170493617 @default.
• W2155134319 hasConceptScore W2155134319C203014093 @default.
• W2155134319 hasConceptScore W2155134319C2776070231 @default.
• W2155134319 hasConceptScore W2155134319C2776709828 @default.
• W2155134319 hasConceptScore W2155134319C2777439022 @default.
• W2155134319 hasConceptScore W2155134319C2778754761 @default.

• next