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- W2155136359 abstract "BL-P1654 is a new α-substituted ureido penicillin which has broad-spectrum activity. Doses of 0.5 and 1.0 g administered by rapid intravenous injection produce mean peak serum concentrations of 40.7 and 80.8 μg/ml, respectively. The same doses administered by 1-h intravenous infusions produce mean peak serum concentrations of 22.6 and 47 μg/ml, respectively. The mean serum concentrations from 1 to 6 h after onset of administration of the drug are the same for both schedules. The mean serum concentration at 6 h after the rapid intravenous injection of 0.5- and 1.0-g doses of BL-P1654 are 3.4 and 5.4 μg/ml, respectively. A dose of 1.0 g every 4 h maintains a serum concentration of about 15 μg/ml. About 50 to 65% of the BL-P1654 is excreted in the urine during the first 6 h." @default.
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- W2155136359 date "1974-04-01" @default.
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- W2155136359 title "Human Pharmacology of 6-[ d -α-(3-Guanylureido)-Phenylacetamido]- Penicillanic Acid (BL-P1654)" @default.
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- W2155136359 doi "https://doi.org/10.1128/aac.5.4.366" @default.
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