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• W2155139733 startingPage "4143" @default.
• W2155139733 abstract "Vascular endothelial growth factor (VEGF) is a key angiogenic molecule that plays an important role in the growth and metastasis of many types of human cancer, including pancreatic adenocarcinoma. In this study, we explored the regulation of VEGF in human pancreatic cancer cells. Over 70% of the human pancreatic cancer cell lines studied in vitro secreted constitutively high levels of VEGF. High VEGF-secreting cells also generally expressed an elevated steady-state level of VEGF mRNA. Kinetic analysis revealed that the elevated steady-state level of VEGF mRNA was due to enhanced VEGF gene transcription and increased constitutive VEGF promoter activity. Deletive mutation analyses of the VEGF promoter revealed that the region from -109 to -38 bp was essential for constitutive VEGF promoter activity. Further deletion and point mutation analyses indicated that mutation of individual or all of the putative Sp1 binding sites reduced or eliminated the constitutive VEGF promoter activity and abrogated the differential activity of the promoter in high and low VEGF-expressing cells. Consistent with the constitutive VEGF transcription activation, a high level of constitutive Sp1 expression and activity was detected in pancreatic cancer cell lines and pancreatic cancer tissue specimens overexpressing VEGF. Collectively, our data demonstrated that constitutive Sp1 activation is essential for the differential overexpression of VEGF, which in turn plays an important role in the angiogenesis and progression of human pancreatic cancer." @default.
• W2155139733 created "2016-06-24" @default.
• W2155139733 creator A5004006552 @default.
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• W2155139733 date "2001-05-15" @default.
• W2155139733 modified "2023-09-25" @default.
• W2155139733 title "Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma." @default.
• W2155139733 cites W103956845 @default.
• W2155139733 cites W1488835155 @default.
• W2155139733 cites W1494416455 @default.
• W2155139733 cites W1503573748 @default.
• W2155139733 cites W1537712767 @default.
• W2155139733 cites W1550364580 @default.
• W2155139733 cites W1576403695 @default.
• W2155139733 cites W1579641819 @default.
• W2155139733 cites W1611565221 @default.
• W2155139733 cites W1748987851 @default.
• W2155139733 cites W1780308454 @default.
• W2155139733 cites W1797904569 @default.
• W2155139733 cites W1828496251 @default.
• W2155139733 cites W1844218774 @default.
• W2155139733 cites W1869499975 @default.
• W2155139733 cites W1870640263 @default.
• W2155139733 cites W1918669574 @default.
• W2155139733 cites W1967194906 @default.
• W2155139733 cites W1969328947 @default.
• W2155139733 cites W1976305765 @default.
• W2155139733 cites W1976697969 @default.
• W2155139733 cites W1978173977 @default.
• W2155139733 cites W1978332905 @default.
• W2155139733 cites W1978340181 @default.
• W2155139733 cites W1983585865 @default.
• W2155139733 cites W1983763042 @default.
• W2155139733 cites W1986469266 @default.
• W2155139733 cites W1988403143 @default.
• W2155139733 cites W1994131389 @default.
• W2155139733 cites W1994953133 @default.
• W2155139733 cites W1998912324 @default.
• W2155139733 cites W2000757618 @default.
• W2155139733 cites W2007675851 @default.
• W2155139733 cites W2010499718 @default.
• W2155139733 cites W2015344488 @default.
• W2155139733 cites W2015809080 @default.
• W2155139733 cites W2019273955 @default.
• W2155139733 cites W2021996182 @default.
• W2155139733 cites W2024681203 @default.
• W2155139733 cites W2031165399 @default.
• W2155139733 cites W2036751011 @default.
• W2155139733 cites W2038449972 @default.
• W2155139733 cites W2041140715 @default.
• W2155139733 cites W2043850275 @default.
• W2155139733 cites W2050003881 @default.
• W2155139733 cites W2057918209 @default.
• W2155139733 cites W2058620644 @default.
• W2155139733 cites W2061834490 @default.
• W2155139733 cites W2062594120 @default.
• W2155139733 cites W2066664309 @default.
• W2155139733 cites W2067727881 @default.
• W2155139733 cites W2080727542 @default.
• W2155139733 cites W2086354706 @default.
• W2155139733 cites W2086652233 @default.
• W2155139733 cites W2087866733 @default.
• W2155139733 cites W2088627897 @default.
• W2155139733 cites W2089088316 @default.
• W2155139733 cites W2097224369 @default.
• W2155139733 cites W2100272171 @default.
• W2155139733 cites W2106169455 @default.
• W2155139733 cites W2106691610 @default.
• W2155139733 cites W2108033371 @default.
• W2155139733 cites W2111080918 @default.
• W2155139733 cites W2112264347 @default.
• W2155139733 cites W2118146357 @default.
• W2155139733 cites W2122276925 @default.
• W2155139733 cites W2125505202 @default.
• W2155139733 cites W2128317694 @default.
• W2155139733 cites W2129873928 @default.
• W2155139733 cites W2132601924 @default.
• W2155139733 cites W2135938642 @default.
• W2155139733 cites W2144383844 @default.
• W2155139733 cites W2145608698 @default.
• W2155139733 cites W2150796809 @default.
• W2155139733 cites W2152505099 @default.
• W2155139733 cites W2154200023 @default.
• W2155139733 cites W2159603425 @default.
• W2155139733 cites W2161604049 @default.
• W2155139733 cites W2163069245 @default.
• W2155139733 cites W2612961129 @default.
• W2155139733 cites W3022518945 @default.
• W2155139733 cites W3149401029 @default.
• W2155139733 cites W37487597 @default.

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