FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155141514> ?p ?o ?g. }

• W2155141514 endingPage "901" @default.
• W2155141514 startingPage "897" @default.
• W2155141514 abstract "Extravasation of vesicant drugs such as vinca alkaloids causes severe injury, which may range from erythema to skin necrosis or ulceration. The skin necrosis may not be fully evident until several weeks or months after the initial damage, and may require surgical intervention. The main treatments for vincristine extravasation are hyaluronidase injection and topical warming, and the aim of treatment is to increase the clearance of the drug from the extravasation site.To investigate the effect of adrenomedullin, a potent vasodilatory peptide, in rats subjected to vincristine-induced extravasation.In total, 36 Wistar albino rats were given intradermal injection of vincristine and saline. The rats were assigned to one of three treatment groups (adrenomedullin, adrenomedullin + hyaluronidase, or hyaluronidase), a control group given vincristine only, or a sham group (saline). Tissue superoxide dismutase (SOD), glutathione peroxidase, malondialdehyde (MDA) and protein content were evaluated in skin biopsies taken on day 22. The ulcer size and histopathological grading scores were also recorded.SOD levels were significantly increased by adrenomedullin and increased by hyaluronidase. Glutathione peroxidase levels were significantly decreased in all four vincristine groups. Tissue MDA levels were highest in the adrenomedullin group. In all four vincristine groups, MDA levels were reduced, indicating preservation from tissue injury. Protein carbonyl (PCO) content levels in the adrenomedullin group were significantly greater than in the other three study groups (P < 0.05). In contrast, PCO levels in the hyaluronidase group were significantly lower than in the other three groups.In this animal model of vincristine-induced extravasation, antioxidant status and histology were preserved by hyaluronidase but worsened by adrenomedullin." @default.
• W2155141514 created "2016-06-24" @default.
• W2155141514 creator A5004208165 @default.
• W2155141514 creator A5009530570 @default.
• W2155141514 creator A5016899633 @default.
• W2155141514 creator A5034017062 @default.
• W2155141514 creator A5053969226 @default.
• W2155141514 creator A5056967843 @default.
• W2155141514 creator A5089646464 @default.
• W2155141514 date "2010-03-19" @default.
• W2155141514 modified "2023-10-18" @default.
• W2155141514 title "Adrenomedullin worsens skin necrosis in rats subjected to vincristine-induced extravasation" @default.
• W2155141514 cites W1567614586 @default.
• W2155141514 cites W1775749144 @default.
• W2155141514 cites W1974169871 @default.
• W2155141514 cites W1978871830 @default.
• W2155141514 cites W2005484168 @default.
• W2155141514 cites W2013424557 @default.
• W2155141514 cites W2016276709 @default.
• W2155141514 cites W2056130588 @default.
• W2155141514 cites W2082802426 @default.
• W2155141514 cites W2134710149 @default.
• W2155141514 doi "https://doi.org/10.1111/j.1365-2230.2010.03803.x" @default.
• W2155141514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20345993" @default.
• W2155141514 hasPublicationYear "2010" @default.
• W2155141514 type Work @default.
• W2155141514 sameAs 2155141514 @default.
• W2155141514 citedByCount "8" @default.
• W2155141514 countsByYear W21551415142012 @default.
• W2155141514 countsByYear W21551415142016 @default.
• W2155141514 countsByYear W21551415142018 @default.
• W2155141514 countsByYear W21551415142019 @default.
• W2155141514 countsByYear W21551415142020 @default.
• W2155141514 crossrefType "journal-article" @default.
• W2155141514 hasAuthorship W2155141514A5004208165 @default.
• W2155141514 hasAuthorship W2155141514A5009530570 @default.
• W2155141514 hasAuthorship W2155141514A5016899633 @default.
• W2155141514 hasAuthorship W2155141514A5034017062 @default.
• W2155141514 hasAuthorship W2155141514A5053969226 @default.
• W2155141514 hasAuthorship W2155141514A5056967843 @default.
• W2155141514 hasAuthorship W2155141514A5089646464 @default.
• W2155141514 hasConcept C126322002 @default.
• W2155141514 hasConcept C134018914 @default.
• W2155141514 hasConcept C142724271 @default.
• W2155141514 hasConcept C170493617 @default.
• W2155141514 hasConcept C181199279 @default.
• W2155141514 hasConcept C185592680 @default.
• W2155141514 hasConcept C2775838275 @default.
• W2155141514 hasConcept C2776151105 @default.
• W2155141514 hasConcept C2776694085 @default.
• W2155141514 hasConcept C2776755627 @default.
• W2155141514 hasConcept C2777152744 @default.
• W2155141514 hasConcept C2777397205 @default.
• W2155141514 hasConcept C2778760513 @default.
• W2155141514 hasConcept C2779429289 @default.
• W2155141514 hasConcept C2779540182 @default.
• W2155141514 hasConcept C2780375986 @default.
• W2155141514 hasConcept C42219234 @default.
• W2155141514 hasConcept C55493867 @default.
• W2155141514 hasConcept C71924100 @default.
• W2155141514 hasConcept C98274493 @default.
• W2155141514 hasConceptScore W2155141514C126322002 @default.
• W2155141514 hasConceptScore W2155141514C134018914 @default.
• W2155141514 hasConceptScore W2155141514C142724271 @default.
• W2155141514 hasConceptScore W2155141514C170493617 @default.
• W2155141514 hasConceptScore W2155141514C181199279 @default.
• W2155141514 hasConceptScore W2155141514C185592680 @default.
• W2155141514 hasConceptScore W2155141514C2775838275 @default.
• W2155141514 hasConceptScore W2155141514C2776151105 @default.
• W2155141514 hasConceptScore W2155141514C2776694085 @default.
• W2155141514 hasConceptScore W2155141514C2776755627 @default.
• W2155141514 hasConceptScore W2155141514C2777152744 @default.
• W2155141514 hasConceptScore W2155141514C2777397205 @default.
• W2155141514 hasConceptScore W2155141514C2778760513 @default.
• W2155141514 hasConceptScore W2155141514C2779429289 @default.
• W2155141514 hasConceptScore W2155141514C2779540182 @default.
• W2155141514 hasConceptScore W2155141514C2780375986 @default.
• W2155141514 hasConceptScore W2155141514C42219234 @default.
• W2155141514 hasConceptScore W2155141514C55493867 @default.
• W2155141514 hasConceptScore W2155141514C71924100 @default.
• W2155141514 hasConceptScore W2155141514C98274493 @default.
• W2155141514 hasIssue "8" @default.
• W2155141514 hasLocation W21551415141 @default.
• W2155141514 hasLocation W21551415142 @default.
• W2155141514 hasOpenAccess W2155141514 @default.
• W2155141514 hasPrimaryLocation W21551415141 @default.
• W2155141514 hasRelatedWork W1993588872 @default.
• W2155141514 hasRelatedWork W2003814569 @default.
• W2155141514 hasRelatedWork W2009477922 @default.
• W2155141514 hasRelatedWork W2024660080 @default.
• W2155141514 hasRelatedWork W2109648091 @default.
• W2155141514 hasRelatedWork W2128099982 @default.
• W2155141514 hasRelatedWork W2155141514 @default.
• W2155141514 hasRelatedWork W2312430269 @default.
• W2155141514 hasRelatedWork W2389511531 @default.
• W2155141514 hasRelatedWork W2978204608 @default.
• W2155141514 hasVolume "35" @default.
• W2155141514 isParatext "false" @default.

• next