FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155143238> ?p ?o ?g. }

• W2155143238 endingPage "267" @default.
• W2155143238 startingPage "258" @default.
• W2155143238 abstract "We employ a clinical multiphoton microscope to monitor in vivo and noninvasively the changes in reduced nicotinamide adenine dinucleotide (NADH) fluorescence of human epidermal cells during arterial occlusion. We correlate these results with measurements of tissue oxy- and deoxyhemoglobin concentration during oxygen deprivation using spatial frequency domain imaging. During arterial occlusion, a decrease in oxyhemoglobin corresponds to an increase in NADH fluorescence in the basal epidermal cells, implying a reduction in basal cell oxidative phosphorylation. The ischemia-induced oxygen deprivation is associated with a strong increase in NADH fluorescence of keratinocytes in layers close to the stratum basale, whereas keratinocytes from epidermal layers closer to the skin surface are not affected. Spatial frequency domain imaging optical property measurements, combined with a multilayer Monte Carlo-based radiative transport model of multiphoton microscopy signal collection in skin, establish that localized tissue optical property changes during occlusion do not impact the observed NADH signal increase. This outcome supports the hypothesis that the vascular contribution to the basal layer oxygen supply is significant and these cells engage in oxidative metabolism. Keratinocytes in the more superficial stratum granulosum are either supplied by atmospheric oxygen or are functionally anaerobic. Based on combined hemodynamic and two-photon excited fluorescence data, the oxygen consumption rate in the stratum basale is estimated to be ∼0.035 μmoles/10(6) cells/h." @default.
• W2155143238 created "2016-06-24" @default.
• W2155143238 creator A5007276201 @default.
• W2155143238 creator A5039626970 @default.
• W2155143238 creator A5042547593 @default.
• W2155143238 creator A5049517030 @default.
• W2155143238 creator A5055387372 @default.
• W2155143238 creator A5083213372 @default.
• W2155143238 creator A5084174746 @default.
• W2155143238 creator A5089747606 @default.
• W2155143238 date "2013-01-01" @default.
• W2155143238 modified "2023-09-30" @default.
• W2155143238 title "In Vivo Multiphoton NADH Fluorescence Reveals Depth-Dependent Keratinocyte Metabolism in Human Skin" @default.
• W2155143238 cites W1497174676 @default.
• W2155143238 cites W1561188729 @default.
• W2155143238 cites W1964790634 @default.
• W2155143238 cites W1979034422 @default.
• W2155143238 cites W1985741844 @default.
• W2155143238 cites W1999204179 @default.
• W2155143238 cites W2003727175 @default.
• W2155143238 cites W2013492930 @default.
• W2155143238 cites W2018478648 @default.
• W2155143238 cites W2018611329 @default.
• W2155143238 cites W2018699521 @default.
• W2155143238 cites W2022920901 @default.
• W2155143238 cites W2024901091 @default.
• W2155143238 cites W2025568741 @default.
• W2155143238 cites W2028138503 @default.
• W2155143238 cites W2028378034 @default.
• W2155143238 cites W2039230527 @default.
• W2155143238 cites W2053040583 @default.
• W2155143238 cites W2054341180 @default.
• W2155143238 cites W2056037003 @default.
• W2155143238 cites W2056431986 @default.
• W2155143238 cites W2056937212 @default.
• W2155143238 cites W2062894986 @default.
• W2155143238 cites W2064886154 @default.
• W2155143238 cites W2069562633 @default.
• W2155143238 cites W2073316479 @default.
• W2155143238 cites W2085388254 @default.
• W2155143238 cites W2092521868 @default.
• W2155143238 cites W2117812417 @default.
• W2155143238 cites W2118061802 @default.
• W2155143238 cites W2132614252 @default.
• W2155143238 cites W2136708034 @default.
• W2155143238 cites W2157505268 @default.
• W2155143238 cites W2160898122 @default.
• W2155143238 cites W2295208326 @default.
• W2155143238 cites W2412248089 @default.
• W2155143238 cites W2462814986 @default.
• W2155143238 cites W349630777 @default.
• W2155143238 cites W4365787523 @default.
• W2155143238 cites W57514727 @default.
• W2155143238 doi "https://doi.org/10.1016/j.bpj.2012.11.3809" @default.
• W2155143238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3540245" @default.
• W2155143238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23332078" @default.
• W2155143238 hasPublicationYear "2013" @default.
• W2155143238 type Work @default.
• W2155143238 sameAs 2155143238 @default.
• W2155143238 citedByCount "98" @default.
• W2155143238 countsByYear W21551432382013 @default.
• W2155143238 countsByYear W21551432382014 @default.
• W2155143238 countsByYear W21551432382015 @default.
• W2155143238 countsByYear W21551432382016 @default.
• W2155143238 countsByYear W21551432382017 @default.
• W2155143238 countsByYear W21551432382018 @default.
• W2155143238 countsByYear W21551432382019 @default.
• W2155143238 countsByYear W21551432382020 @default.
• W2155143238 countsByYear W21551432382021 @default.
• W2155143238 countsByYear W21551432382022 @default.
• W2155143238 countsByYear W21551432382023 @default.
• W2155143238 crossrefType "journal-article" @default.
• W2155143238 hasAuthorship W2155143238A5007276201 @default.
• W2155143238 hasAuthorship W2155143238A5039626970 @default.
• W2155143238 hasAuthorship W2155143238A5042547593 @default.
• W2155143238 hasAuthorship W2155143238A5049517030 @default.
• W2155143238 hasAuthorship W2155143238A5055387372 @default.
• W2155143238 hasAuthorship W2155143238A5083213372 @default.
• W2155143238 hasAuthorship W2155143238A5084174746 @default.
• W2155143238 hasAuthorship W2155143238A5089747606 @default.
• W2155143238 hasBestOaLocation W21551432381 @default.
• W2155143238 hasConcept C120665830 @default.
• W2155143238 hasConcept C121332964 @default.
• W2155143238 hasConcept C12554922 @default.
• W2155143238 hasConcept C142724271 @default.
• W2155143238 hasConcept C150903083 @default.
• W2155143238 hasConcept C169274487 @default.
• W2155143238 hasConcept C178790620 @default.
• W2155143238 hasConcept C181199279 @default.
• W2155143238 hasConcept C185592680 @default.
• W2155143238 hasConcept C207001950 @default.
• W2155143238 hasConcept C2776901170 @default.
• W2155143238 hasConcept C2777459323 @default.
• W2155143238 hasConcept C2778370115 @default.
• W2155143238 hasConcept C2779922919 @default.
• W2155143238 hasConcept C540031477 @default.
• W2155143238 hasConcept C54355233 @default.
• W2155143238 hasConcept C55493867 @default.

• next