Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155143852> ?p ?o ?g. }
- W2155143852 endingPage "978" @default.
- W2155143852 startingPage "973" @default.
- W2155143852 abstract "In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds." @default.
- W2155143852 created "2016-06-24" @default.
- W2155143852 creator A5007964042 @default.
- W2155143852 creator A5022264314 @default.
- W2155143852 creator A5022409432 @default.
- W2155143852 creator A5024642832 @default.
- W2155143852 creator A5050598036 @default.
- W2155143852 creator A5053075000 @default.
- W2155143852 creator A5059411156 @default.
- W2155143852 creator A5062412676 @default.
- W2155143852 creator A5063200184 @default.
- W2155143852 creator A5080439570 @default.
- W2155143852 date "2009-08-16" @default.
- W2155143852 modified "2023-10-06" @default.
- W2155143852 title "Molecular mechanisms for protein-encoded inheritance" @default.
- W2155143852 cites W1967239474 @default.
- W2155143852 cites W1973758214 @default.
- W2155143852 cites W1977646659 @default.
- W2155143852 cites W1978959047 @default.
- W2155143852 cites W1987686455 @default.
- W2155143852 cites W1993205343 @default.
- W2155143852 cites W1995496955 @default.
- W2155143852 cites W2002886872 @default.
- W2155143852 cites W2004098528 @default.
- W2155143852 cites W2016399127 @default.
- W2155143852 cites W2025146643 @default.
- W2155143852 cites W2026426465 @default.
- W2155143852 cites W2029514908 @default.
- W2155143852 cites W2031014005 @default.
- W2155143852 cites W2032843390 @default.
- W2155143852 cites W2034170455 @default.
- W2155143852 cites W2034442505 @default.
- W2155143852 cites W2038004674 @default.
- W2155143852 cites W2046843922 @default.
- W2155143852 cites W2059804089 @default.
- W2155143852 cites W2064316344 @default.
- W2155143852 cites W2064722614 @default.
- W2155143852 cites W2064931700 @default.
- W2155143852 cites W2072613948 @default.
- W2155143852 cites W2077790507 @default.
- W2155143852 cites W2082592680 @default.
- W2155143852 cites W2085899859 @default.
- W2155143852 cites W2087357689 @default.
- W2155143852 cites W2094337931 @default.
- W2155143852 cites W2095076518 @default.
- W2155143852 cites W2101298197 @default.
- W2155143852 cites W2113631794 @default.
- W2155143852 cites W2117537971 @default.
- W2155143852 cites W2119651404 @default.
- W2155143852 cites W2141566674 @default.
- W2155143852 cites W2142366168 @default.
- W2155143852 cites W2143495798 @default.
- W2155143852 cites W2144481414 @default.
- W2155143852 cites W2154907250 @default.
- W2155143852 cites W2161337867 @default.
- W2155143852 cites W2162741488 @default.
- W2155143852 cites W2163210644 @default.
- W2155143852 cites W2324660492 @default.
- W2155143852 doi "https://doi.org/10.1038/nsmb.1643" @default.
- W2155143852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640378" @default.
- W2155143852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19684598" @default.
- W2155143852 hasPublicationYear "2009" @default.
- W2155143852 type Work @default.
- W2155143852 sameAs 2155143852 @default.
- W2155143852 citedByCount "244" @default.
- W2155143852 countsByYear W21551438522012 @default.
- W2155143852 countsByYear W21551438522013 @default.
- W2155143852 countsByYear W21551438522014 @default.
- W2155143852 countsByYear W21551438522015 @default.
- W2155143852 countsByYear W21551438522016 @default.
- W2155143852 countsByYear W21551438522017 @default.
- W2155143852 countsByYear W21551438522018 @default.
- W2155143852 countsByYear W21551438522019 @default.
- W2155143852 countsByYear W21551438522020 @default.
- W2155143852 countsByYear W21551438522021 @default.
- W2155143852 countsByYear W21551438522022 @default.
- W2155143852 countsByYear W21551438522023 @default.
- W2155143852 crossrefType "journal-article" @default.
- W2155143852 hasAuthorship W2155143852A5007964042 @default.
- W2155143852 hasAuthorship W2155143852A5022264314 @default.
- W2155143852 hasAuthorship W2155143852A5022409432 @default.
- W2155143852 hasAuthorship W2155143852A5024642832 @default.
- W2155143852 hasAuthorship W2155143852A5050598036 @default.
- W2155143852 hasAuthorship W2155143852A5053075000 @default.
- W2155143852 hasAuthorship W2155143852A5059411156 @default.
- W2155143852 hasAuthorship W2155143852A5062412676 @default.
- W2155143852 hasAuthorship W2155143852A5063200184 @default.
- W2155143852 hasAuthorship W2155143852A5080439570 @default.
- W2155143852 hasBestOaLocation W21551438522 @default.
- W2155143852 hasConcept C104317684 @default.
- W2155143852 hasConcept C127716648 @default.
- W2155143852 hasConcept C142724271 @default.
- W2155143852 hasConcept C24107716 @default.
- W2155143852 hasConcept C2779134260 @default.
- W2155143852 hasConcept C3019804061 @default.
- W2155143852 hasConcept C47701112 @default.
- W2155143852 hasConcept C54355233 @default.
- W2155143852 hasConcept C55493867 @default.