FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155144075> ?p ?o ?g. }

• W2155144075 endingPage "5708" @default.
• W2155144075 startingPage "5695" @default.
• W2155144075 abstract "Abstract Mechanisms underlying progression to androgen-independent prostate cancer following radical ablation therapy remain poorly defined. Although intraprostatic infections have been highlighted as potential cofactors, pathogen influences on pathways that support tumor regrowth are not known. To explore this provocative concept, we derived androgen-sensitive and -insensitive prostate epithelial cells persistently infected with human herpesvirus 8 (HHV-8), an oncogenic herpesvirus that has been detected in normal prostate epithelium, prostate adenocarcinoma, and biologic fluids of patients with prostate cancer, to explore its effects on transition to hormone-refractory disease. Strikingly, we found that HHV-8 infection of androgen-sensitive prostate cancer cells conferred the capacity for androgen-independent growth. This effect was associated with altered expression and transcriptional activity of the androgen receptor (AR). However, HHV-8 infection bypassed AR signaling by promoting enhancer of zeste homolog 2 (EZH2)–mediated epigenetic silencing of tumor-suppressor genes, including MSMB and DAB2IP that are often inactivated in advanced disease. Furthermore, we found that HHV-8 triggered epithelial-to-mesenchymal transition. Although HHV-8 has not been linked etiologically to prostate cancer, virologic outcomes revealed by our study provide mechanistic insight into how intraprostatic infections could constitute risk for progression to androgen-independent metastatic disease where EZH2 has been implicated. Taken together, our findings prompt further evaluations of the relationship between HHV-8 infections and risk of advanced prostate cancer. Cancer Res; 73(18); 5695–708. ©2013 AACR." @default.
• W2155144075 created "2016-06-24" @default.
• W2155144075 creator A5018572038 @default.
• W2155144075 creator A5049953188 @default.
• W2155144075 creator A5064293919 @default.
• W2155144075 creator A5068428193 @default.
• W2155144075 creator A5078234740 @default.
• W2155144075 date "2013-09-15" @default.
• W2155144075 modified "2023-10-04" @default.
• W2155144075 title "Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth" @default.
• W2155144075 cites W1491026704 @default.
• W2155144075 cites W1968278169 @default.
• W2155144075 cites W1969241521 @default.
• W2155144075 cites W1978751114 @default.
• W2155144075 cites W2006176534 @default.
• W2155144075 cites W2006382528 @default.
• W2155144075 cites W2015779295 @default.
• W2155144075 cites W2016371780 @default.
• W2155144075 cites W2017148342 @default.
• W2155144075 cites W2018649033 @default.
• W2155144075 cites W2028853380 @default.
• W2155144075 cites W2034575708 @default.
• W2155144075 cites W2036710106 @default.
• W2155144075 cites W2042119456 @default.
• W2155144075 cites W2042156273 @default.
• W2155144075 cites W2054101834 @default.
• W2155144075 cites W2056524601 @default.
• W2155144075 cites W2059724367 @default.
• W2155144075 cites W2064293531 @default.
• W2155144075 cites W2067444184 @default.
• W2155144075 cites W2071141495 @default.
• W2155144075 cites W2074174652 @default.
• W2155144075 cites W2076378299 @default.
• W2155144075 cites W2076583198 @default.
• W2155144075 cites W2079298594 @default.
• W2155144075 cites W2079492607 @default.
• W2155144075 cites W2081365151 @default.
• W2155144075 cites W2093340006 @default.
• W2155144075 cites W2100365251 @default.
• W2155144075 cites W2118055719 @default.
• W2155144075 cites W2120664210 @default.
• W2155144075 cites W2127684282 @default.
• W2155144075 cites W2136089977 @default.
• W2155144075 cites W2140611891 @default.
• W2155144075 cites W2142798790 @default.
• W2155144075 cites W2143090686 @default.
• W2155144075 cites W2144347332 @default.
• W2155144075 cites W2146391441 @default.
• W2155144075 cites W2158734599 @default.
• W2155144075 cites W2158944729 @default.
• W2155144075 cites W2159163386 @default.
• W2155144075 cites W2160713126 @default.
• W2155144075 cites W2249954424 @default.
• W2155144075 cites W2312580646 @default.
• W2155144075 cites W2323047660 @default.
• W2155144075 doi "https://doi.org/10.1158/0008-5472.can-12-4196" @default.
• W2155144075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24005834" @default.
• W2155144075 hasPublicationYear "2013" @default.
• W2155144075 type Work @default.
• W2155144075 sameAs 2155144075 @default.
• W2155144075 citedByCount "14" @default.
• W2155144075 countsByYear W21551440752014 @default.
• W2155144075 countsByYear W21551440752018 @default.
• W2155144075 countsByYear W21551440752020 @default.
• W2155144075 countsByYear W21551440752021 @default.
• W2155144075 countsByYear W21551440752022 @default.
• W2155144075 countsByYear W21551440752023 @default.
• W2155144075 crossrefType "journal-article" @default.
• W2155144075 hasAuthorship W2155144075A5018572038 @default.
• W2155144075 hasAuthorship W2155144075A5049953188 @default.
• W2155144075 hasAuthorship W2155144075A5064293919 @default.
• W2155144075 hasAuthorship W2155144075A5068428193 @default.
• W2155144075 hasAuthorship W2155144075A5078234740 @default.
• W2155144075 hasBestOaLocation W21551440751 @default.
• W2155144075 hasConcept C104317684 @default.
• W2155144075 hasConcept C119056186 @default.
• W2155144075 hasConcept C121608353 @default.
• W2155144075 hasConcept C126322002 @default.
• W2155144075 hasConcept C2776235491 @default.
• W2155144075 hasConcept C2777911890 @default.
• W2155144075 hasConcept C2779013556 @default.
• W2155144075 hasConcept C2780192828 @default.
• W2155144075 hasConcept C41091548 @default.
• W2155144075 hasConcept C50171091 @default.
• W2155144075 hasConcept C502942594 @default.
• W2155144075 hasConcept C54355233 @default.
• W2155144075 hasConcept C61367390 @default.
• W2155144075 hasConcept C71315377 @default.
• W2155144075 hasConcept C71924100 @default.
• W2155144075 hasConcept C76419328 @default.
• W2155144075 hasConcept C86803240 @default.
• W2155144075 hasConceptScore W2155144075C104317684 @default.
• W2155144075 hasConceptScore W2155144075C119056186 @default.
• W2155144075 hasConceptScore W2155144075C121608353 @default.
• W2155144075 hasConceptScore W2155144075C126322002 @default.
• W2155144075 hasConceptScore W2155144075C2776235491 @default.
• W2155144075 hasConceptScore W2155144075C2777911890 @default.
• W2155144075 hasConceptScore W2155144075C2779013556 @default.

• next