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• W2155144670 endingPage "572" @default.
• W2155144670 startingPage "565" @default.
• W2155144670 abstract "Calcium homeostasis was investigated in male BB rats with a diabetes duration of 3–4 weeks and compared with that in nondiabetic littermates either fed ad libitum or receiving selective semistarvation or an oral Ca supplement to obtain additional weight-matched and Ca intake-matched control groups. Diabetic rats had markedly increased food and Ca intake, so that their net Ca balance remained positive despite a 13-fold increase in urinary Ca excretion and a disappearance of active duodenal Ca absorption. Decreased duodenal Ca uptake correlated with decreased 1,25-(OH)2D3 levels (89 ± 15 vs. 160 ± 13 pg/ml in nondiabetic rats), decreased duodenal 9K Ca-binding protein concentrations (10 ± 1 vs. 21 ± 2 μg/mg protein), and decreased number of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]- binding sites in duodenum, although the binding affinity was above normal. Nondiabetic Ca-supplemented rats exhibited a similar response: decreased 1,25-(OH)2D3 (95 ± 8 pg/ml) and 9K Ca-binding protein (7 ± 0.5 ∧g/mg protein) concentrations, decreased active duodenal Ca uptake, increased urinary Ca excretion, and a normal net Ca balance. Plasma vitamin D-binding protein levels were decreased by 62% in diabetic rats, due to a marked decrease in production rate, while the plasma half-time remained normal. The free 1,25- (OH)2D3 index was highest in diabetic rats, suggesting partial vitamin D resistance at the duodenal level. In semistarved rats, 1,25-(OH)2D3 levels and active Ca uptake remained normal, and the free 1,25-(OH)2D3 index was increased, together with suppressed vitamin D-binding protein levels. These studies indicate that nutritional anormalities may contribute to but cannot totally explain the disturbances in vitamin D metabolism, transport, or action at the intestinal level. (Endocrinology124: 565–572, 1989)" @default.
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• W2155144670 date "1989-02-01" @default.
• W2155144670 modified "2023-09-27" @default.
• W2155144670 title "Bone Mineral Homeostasis in Spontaneously Diabetic BB Rats. I. Abnormal Vitamin D Metabolism and Impaired Active Intestinal Calcium Absorption*" @default.
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• W2155144670 doi "https://doi.org/10.1210/endo-124-2-565" @default.
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