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• W2155144802 abstract "Shear stress regulates endothelial nitric oxide and superoxide (O 2 −· ) production, implicating the role of NADPH oxidase activity. It is unknown whether shear stress regulates the sources of reactive species production, consequent low-density lipoprotein (LDL) modification, and initiation of inflammatory events. Bovine aortic endothelial cells (BAECs) in the presence of 50 μg/mL of native LDL were exposed to (1) pulsatile flow with a mean shear stress (τ ave ) of 25 dyne/cm 2 and (2) oscillating flow at τ ave of 0. After 4 hours, aliquots of culture medium were collected for high-performance liquid chromatography analyses of electronegative LDL species, described as LDL − and LDL 2− . In response to oscillatory shear stress, gp91 phox mRNA expression was upregulated by 2.9±0.3-fold, and its homologue, Nox4, by 3.9±0.9-fold ( P <0.05, n=4), with a corresponding increase in O 2 −· production rate. The proportion of LDL − and LDL 2− relative to static conditions increased by 67±17% and 30±7%, respectively, with the concomitant upregulation of monocyte chemoattractant protein-1 expression and increase in monocyte/BAEC binding ( P <0.05, n=5). In contrast, pulsatile flow downregulated both gp91 phox and Nox4 mRNA expression (by 1.8±0.2-fold and 3.0±0.12-fold, respectively), with an accompanying reduction in O 2 −· production, reduction in the extent of LDL modification (51±12% for LDL − and 30±7% for LDL 2− ), and monocyte/BAEC binding. The flow-dependent LDL oxidation is determined in part by the NADPH oxidase activity. The formation of modified LDL via O 2 −· production may also affect the regulation of monocyte chemoattractant protein-1 expression and monocyte/BAEC binding." @default.
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• W2155144802 date "2003-12-12" @default.
• W2155144802 modified "2023-09-23" @default.
• W2155144802 title "Pulsatile Versus Oscillatory Shear Stress Regulates NADPH Oxidase Subunit Expression" @default.
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• W2155144802 doi "https://doi.org/10.1161/01.res.0000104087.29395.66" @default.
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