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• W2155153609 abstract "Mangifera indica (Mango) is used in folk medicine for treatment of d ifferent types of diseases, and its anti-inflammatory and free radica l scavenging activities have been demonstrated. The present study evaluated the effects of commercial ( vimang) and hydroalcoholic extract of Mango on gentamicin-induced nephrotoxicity in rat. Materials and Methods: Female Wistar rats were treated with vimang (50 an d 100 mg/kg) for 18 days, or hydroalcoholic extract (200 and 400 mg/kg) for 18 days as preventive groups and others with vimang (100 mg/kg) for 8 days, or hydroalcoholic extract (400 mg/kg) for 8 days as treatment groups and also gentamicin (GM) was used at 80 mg/kg/day for eight days, starting from day 10. At the end of treatment, blood and urine samples were taken fo r measurement of creatinine (Cr) and BUN. The kidney was prepared for histological evaluation. Results: Serum Cr and urea concentrations as well as renal tissue injury increased significantly in GM group compared with the control group. Hydroalcoholic extract of Mango at 200mg/kg was able to reduce plasma Cr and urea concentrations significan tly as well as kidney tissue necrosis. Vimang (50 and 100 mg/kg) and hydroalcoholic extract of Mango (200mg/kg) also prevented kidney tissue damage compared with the control group. Conclusion: Mango products were able to improve kidney function in an established model of GM- induced nephrotoxicity in the rat. The beneficial e ffects of Mango on the rat kidney seem to be dose and time-dependent. However, more investigations are needed to elucidate Mango action on GM- induced renal toxicity." @default.
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• W2155153609 date "2011-09-01" @default.
• W2155153609 modified "2023-09-23" @default.
• W2155153609 title "Effect of commercial (vimang) and hydroalcoholic extract of Mangifera indica (Mango) on gentamicin-induced nephrotoxicity in rat" @default.
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• W2155153609 doi "https://doi.org/10.22038/ajp.2011.128" @default.
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