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• W2155163052 startingPage "7599" @default.
• W2155163052 abstract "Activation of the climbing fiber input powerfully excites cerebellar Purkinje cells via hundreds of widespread dendritic synapses, triggering dendritic spikes as well as a characteristic high-frequency burst of somatic spikes known as the complex spike. To investigate the relationship between dendritic spikes and the spikelets within the somatic complex spike, and to evaluate the importance of the dendritic distribution of climbing fiber synapses, we made simultaneous somatic and dendritic patch-clamp recordings from Purkinje cells in cerebellar slices. Injection of large climbing fiber-like synaptic conductances at the soma using dynamic clamp was sufficient to reproduce the complex spike, independently of dendritic spikes, indicating that neither a dendritic synaptic distribution nor dendritic spikes are required. Furthermore, we found that dendritic spikes are not directly linked to spikelets in the complex spike, and that each dendritic spike is associated with only 0.24 ± 0.09 extra somatic spikelets. Rather, we demonstrate that dendritic spikes regulate the pause in firing that follows the complex spike. Finally, using dual somatic and axonal recording, we show that all spikelets in the complex spike are axonally generated. Thus, complex spike generation proceeds relatively independently of dendritic spikes, reflecting the dual functional role of climbing fiber input: triggering plasticity at dendritic synapses and generating a distinct output signal in the axon. The encoding of dendritic spiking by the post-complex spike pause provides a novel computational function for dendritic spikes, which could serve to link these two roles at the level of the target neurons in the deep cerebellar nuclei." @default.
• W2155163052 created "2016-06-24" @default.
• W2155163052 creator A5023920449 @default.
• W2155163052 creator A5066995770 @default.
• W2155163052 creator A5088723671 @default.
• W2155163052 date "2008-07-23" @default.
• W2155163052 modified "2023-10-12" @default.
• W2155163052 title "The Origin of the Complex Spike in Cerebellar Purkinje Cells" @default.
• W2155163052 cites W128802464 @default.
• W2155163052 cites W1484102060 @default.
• W2155163052 cites W1502963283 @default.
• W2155163052 cites W1588059035 @default.
• W2155163052 cites W1614584972 @default.
• W2155163052 cites W1635674943 @default.
• W2155163052 cites W1789081904 @default.
• W2155163052 cites W1849270082 @default.
• W2155163052 cites W1906539094 @default.
• W2155163052 cites W1951749181 @default.
• W2155163052 cites W1964016839 @default.
• W2155163052 cites W1965741585 @default.
• W2155163052 cites W1967086564 @default.
• W2155163052 cites W1969483526 @default.
• W2155163052 cites W1971366695 @default.
• W2155163052 cites W1974598512 @default.
• W2155163052 cites W1990389323 @default.
• W2155163052 cites W1990406066 @default.
• W2155163052 cites W1991247470 @default.
• W2155163052 cites W1994435350 @default.
• W2155163052 cites W1999137369 @default.
• W2155163052 cites W2002897878 @default.
• W2155163052 cites W2004921550 @default.
• W2155163052 cites W2010098657 @default.
• W2155163052 cites W2012041126 @default.
• W2155163052 cites W2013035507 @default.
• W2155163052 cites W2014501805 @default.
• W2155163052 cites W2019528933 @default.
• W2155163052 cites W2020030874 @default.
• W2155163052 cites W2024115686 @default.
• W2155163052 cites W2025828594 @default.
• W2155163052 cites W2027182866 @default.
• W2155163052 cites W2030866654 @default.
• W2155163052 cites W2044648666 @default.
• W2155163052 cites W2046501957 @default.
• W2155163052 cites W2047758880 @default.
• W2155163052 cites W2048701474 @default.
• W2155163052 cites W2057613746 @default.
• W2155163052 cites W2063027609 @default.
• W2155163052 cites W2065797962 @default.
• W2155163052 cites W2068828473 @default.
• W2155163052 cites W2070711430 @default.
• W2155163052 cites W2077292419 @default.
• W2155163052 cites W2081549844 @default.
• W2155163052 cites W2085091797 @default.
• W2155163052 cites W2090278031 @default.
• W2155163052 cites W2091828531 @default.
• W2155163052 cites W2092917982 @default.
• W2155163052 cites W2096424464 @default.
• W2155163052 cites W2098314540 @default.
• W2155163052 cites W2099676980 @default.
• W2155163052 cites W2100052544 @default.
• W2155163052 cites W2100056505 @default.
• W2155163052 cites W2100448934 @default.
• W2155163052 cites W2102661539 @default.
• W2155163052 cites W2104321133 @default.
• W2155163052 cites W2106307904 @default.
• W2155163052 cites W2108072597 @default.
• W2155163052 cites W2109161455 @default.
• W2155163052 cites W2110655576 @default.
• W2155163052 cites W2111901536 @default.
• W2155163052 cites W2115987813 @default.
• W2155163052 cites W2117829171 @default.
• W2155163052 cites W2124625934 @default.
• W2155163052 cites W2129485669 @default.
• W2155163052 cites W2131856835 @default.
• W2155163052 cites W2131921751 @default.
• W2155163052 cites W2133406691 @default.
• W2155163052 cites W2148218137 @default.
• W2155163052 cites W2153499119 @default.
• W2155163052 cites W2160880533 @default.
• W2155163052 cites W2161152720 @default.
• W2155163052 cites W2161902422 @default.
• W2155163052 cites W2187967377 @default.
• W2155163052 cites W2309873395 @default.
• W2155163052 cites W2409275124 @default.
• W2155163052 cites W2412094854 @default.
• W2155163052 cites W2412595955 @default.
• W2155163052 cites W2422402661 @default.
• W2155163052 cites W4214868137 @default.
• W2155163052 cites W4234546939 @default.
• W2155163052 cites W4235268804 @default.
• W2155163052 cites W4239731216 @default.
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• W2155163052 doi "https://doi.org/10.1523/jneurosci.0559-08.2008" @default.
• W2155163052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2730632" @default.
• W2155163052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18650337" @default.
• W2155163052 hasPublicationYear "2008" @default.
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