FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155163956> ?p ?o ?g. }

• W2155163956 endingPage "5118" @default.
• W2155163956 startingPage "5109" @default.
• W2155163956 abstract "In bacteria, promoter identification by RNA polymerase is mediated by a dissociable σ factor. The housekeeping σ 70 factor of Escherichia coli recognizes two well characterized DNA sequence elements, known as the ‘−10’ and ‘−35’ hexamers. These elements are separated by ‘spacer’ DNA, the sequence of which is generally considered unimportant. Here, we use a combination of bioinformatics, genetics and biochemistry to show that σ 70 can sense the sequence and conformation of the promoter spacer region. Our data illustrate how alterations in spacer region sequence can increase promoter activity. This stimulatory effect requires σ 70 side chain R451, which is located in close proximity to the non-template strand at promoter position −18. Conversely, R451 is not required to mediate transcriptional stimulation by improvement of the −10 element. Mutation of σ 70 residue R451, which is highly conserved, results in reduced growth rate, consistent with a central role in promoter recognition." @default.
• W2155163956 created "2016-06-24" @default.
• W2155163956 creator A5018564313 @default.
• W2155163956 creator A5024796305 @default.
• W2155163956 creator A5046083835 @default.
• W2155163956 creator A5074883106 @default.
• W2155163956 date "2011-03-11" @default.
• W2155163956 modified "2023-09-29" @default.
• W2155163956 title "Escherichia coli σ 70 senses sequence and conformation of the promoter spacer region" @default.
• W2155163956 cites W1564164899 @default.
• W2155163956 cites W1600905922 @default.
• W2155163956 cites W1644344961 @default.
• W2155163956 cites W1942361847 @default.
• W2155163956 cites W1971820016 @default.
• W2155163956 cites W1975232273 @default.
• W2155163956 cites W1977866250 @default.
• W2155163956 cites W1979300708 @default.
• W2155163956 cites W1996642589 @default.
• W2155163956 cites W1999531408 @default.
• W2155163956 cites W2008566545 @default.
• W2155163956 cites W2013617142 @default.
• W2155163956 cites W2022245842 @default.
• W2155163956 cites W2022829653 @default.
• W2155163956 cites W2035721356 @default.
• W2155163956 cites W2039555609 @default.
• W2155163956 cites W2042814467 @default.
• W2155163956 cites W2056068767 @default.
• W2155163956 cites W205657959 @default.
• W2155163956 cites W2060325057 @default.
• W2155163956 cites W2061638026 @default.
• W2155163956 cites W2071090620 @default.
• W2155163956 cites W2071424950 @default.
• W2155163956 cites W2075716499 @default.
• W2155163956 cites W2084909105 @default.
• W2155163956 cites W2085077556 @default.
• W2155163956 cites W2088351463 @default.
• W2155163956 cites W2091774406 @default.
• W2155163956 cites W2114624600 @default.
• W2155163956 cites W2126217507 @default.
• W2155163956 cites W2143641256 @default.
• W2155163956 cites W2146254376 @default.
• W2155163956 cites W2147057508 @default.
• W2155163956 cites W2153544373 @default.
• W2155163956 cites W2168597324 @default.
• W2155163956 cites W4298176137 @default.
• W2155163956 doi "https://doi.org/10.1093/nar/gkr080" @default.
• W2155163956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130263" @default.
• W2155163956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21398630" @default.
• W2155163956 hasPublicationYear "2011" @default.
• W2155163956 type Work @default.
• W2155163956 sameAs 2155163956 @default.
• W2155163956 citedByCount "56" @default.
• W2155163956 countsByYear W21551639562012 @default.
• W2155163956 countsByYear W21551639562013 @default.
• W2155163956 countsByYear W21551639562014 @default.
• W2155163956 countsByYear W21551639562015 @default.
• W2155163956 countsByYear W21551639562016 @default.
• W2155163956 countsByYear W21551639562017 @default.
• W2155163956 countsByYear W21551639562019 @default.
• W2155163956 countsByYear W21551639562020 @default.
• W2155163956 countsByYear W21551639562021 @default.
• W2155163956 countsByYear W21551639562022 @default.
• W2155163956 countsByYear W21551639562023 @default.
• W2155163956 crossrefType "journal-article" @default.
• W2155163956 hasAuthorship W2155163956A5018564313 @default.
• W2155163956 hasAuthorship W2155163956A5024796305 @default.
• W2155163956 hasAuthorship W2155163956A5046083835 @default.
• W2155163956 hasAuthorship W2155163956A5074883106 @default.
• W2155163956 hasBestOaLocation W21551639561 @default.
• W2155163956 hasConcept C100594029 @default.
• W2155163956 hasConcept C101762097 @default.
• W2155163956 hasConcept C104317684 @default.
• W2155163956 hasConcept C128319531 @default.
• W2155163956 hasConcept C138885662 @default.
• W2155163956 hasConcept C150194340 @default.
• W2155163956 hasConcept C153911025 @default.
• W2155163956 hasConcept C179926584 @default.
• W2155163956 hasConcept C199216141 @default.
• W2155163956 hasConcept C2776449523 @default.
• W2155163956 hasConcept C2778112365 @default.
• W2155163956 hasConcept C3017666073 @default.
• W2155163956 hasConcept C41895202 @default.
• W2155163956 hasConcept C54355233 @default.
• W2155163956 hasConcept C547475151 @default.
• W2155163956 hasConcept C552990157 @default.
• W2155163956 hasConcept C86803240 @default.
• W2155163956 hasConceptScore W2155163956C100594029 @default.
• W2155163956 hasConceptScore W2155163956C101762097 @default.
• W2155163956 hasConceptScore W2155163956C104317684 @default.
• W2155163956 hasConceptScore W2155163956C128319531 @default.
• W2155163956 hasConceptScore W2155163956C138885662 @default.
• W2155163956 hasConceptScore W2155163956C150194340 @default.
• W2155163956 hasConceptScore W2155163956C153911025 @default.
• W2155163956 hasConceptScore W2155163956C179926584 @default.
• W2155163956 hasConceptScore W2155163956C199216141 @default.
• W2155163956 hasConceptScore W2155163956C2776449523 @default.
• W2155163956 hasConceptScore W2155163956C2778112365 @default.
• W2155163956 hasConceptScore W2155163956C3017666073 @default.

• next