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- W2155164361 abstract "Efficient delivery of small interfering (si)RNA to specific cell populations in vivo remains a formidable challenge to its successful therapeutic application. We show that siRNA synthetically linked to a CpG oligonucleotide agonist of toll-like receptor (TLR)9 targets and silences genes in TLR9(+) myeloid cells and B cells, both of which are key components of the tumor microenvironment. When a CpG-conjugated siRNA that targets the immune suppressor gene Stat3 is injected in mice either locally at the tumor site or intravenously, it enters tumor-associated dendritic cells, macrophages and B cells. Silencing of Stat3 leads to activation of tumor-associated immune cells and ultimately to potent antitumor immune responses. Our findings demonstrate the potential of TLR agonist-siRNA conjugates for targeted gene silencing coupled with TLR stimulation and immune activation in the tumor microenvironment." @default.
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- W2155164361 date "2009-09-13" @default.
- W2155164361 modified "2023-10-18" @default.
- W2155164361 title "In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses" @default.
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- W2155164361 doi "https://doi.org/10.1038/nbt.1564" @default.
- W2155164361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846721" @default.
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