FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155171410> ?p ?o ?g. }

• W2155171410 endingPage "465" @default.
• W2155171410 startingPage "460" @default.
• W2155171410 abstract "<h2>Abstract</h2> A rapid high‐performance liquid chromatographic assay was developed for the determination of amiodarone (<b>1</b>) and its <i>N</i>‐deethyl metabolite (desethylamiodarone, <b>2</b>) in plasma, urine, and bile. Analysis was performed on a C₁₈ reversed‐phase column and precolumn using a mobile phase consisting of methanol:water:58% ammonium hydroxide (94:4:2) delivered at a flow rate of 1.5mL/min. The eluant was monitored at 244nm. Under these conditions, <b>1</b>, <b>2</b>, and the internal standard eluted with retention times of 5.5, 4.6, and 6.8 min, respectively. Samples (100 μL) of plasma were prepared by precipitating the plasma proteins with acetonitrile containing the internal standard and injecting an aliquot of the supernatant directly onto the column. Samples (100 μL) of urine and bile were prepared for injection by acidifying the sample with concentrated HCl and then extracting the mixture with six volumes of 2,2‐dimethoxyproprane. The recovery of <b>1</b> and <b>2</b> from plasma was virtually complete. The recovery from urine and bile was 80–90% for <b>1</b> and 60–65% for <b>2</b>. The limit of sensitivity of both compounds in plasma was 100 ng/mL. For urine and bile, the detection limits were 1 and 5 μg/mL, respectively. Over the plasma concentration range of 0.1–10.0 μg/mL, the within‐day CV ranged from 1 to 10% for <b>1</b> and from 1 to 8% for <b>2</b>. The between‐day CV ranged from 2 to 12% and from 1 to 17% for <b>1</b> and <b>2</b>, respectively. Of 44 drugs tested for potential assay interference, four interfered with the determination of <b>2</b> and one with the analysis of <b>1</b>. The assay has been used for pharmacokinetic studies in rats and routine monitoring of the concentrations of <b>1</b> and <b>2</b> in human plasma." @default.
• W2155171410 created "2016-06-24" @default.
• W2155171410 creator A5002299630 @default.
• W2155171410 creator A5019443689 @default.
• W2155171410 date "1985-04-01" @default.
• W2155171410 modified "2023-09-23" @default.
• W2155171410 title "Rapid Liquid Chromatographic Assay for the Determination of Amiodarone and Its N-Deethyl Metabolite in Plasma, Urine, and Bile" @default.
• W2155171410 cites W1965695368 @default.
• W2155171410 cites W1971354741 @default.
• W2155171410 cites W1983541140 @default.
• W2155171410 cites W2011795826 @default.
• W2155171410 cites W2019366863 @default.
• W2155171410 cites W2031488848 @default.
• W2155171410 cites W2041069426 @default.
• W2155171410 cites W2047161474 @default.
• W2155171410 cites W2048954973 @default.
• W2155171410 cites W2058640270 @default.
• W2155171410 cites W2078515066 @default.
• W2155171410 cites W2078754141 @default.
• W2155171410 cites W2079577781 @default.
• W2155171410 cites W2086952317 @default.
• W2155171410 cites W2089577814 @default.
• W2155171410 cites W2125231766 @default.
• W2155171410 cites W2141513083 @default.
• W2155171410 cites W2144604511 @default.
• W2155171410 cites W2167853422 @default.
• W2155171410 cites W2244230722 @default.
• W2155171410 cites W2395245827 @default.
• W2155171410 doi "https://doi.org/10.1002/jps.2600740418" @default.
• W2155171410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3999009" @default.
• W2155171410 hasPublicationYear "1985" @default.
• W2155171410 type Work @default.
• W2155171410 sameAs 2155171410 @default.
• W2155171410 citedByCount "18" @default.
• W2155171410 countsByYear W21551714102013 @default.
• W2155171410 countsByYear W21551714102022 @default.
• W2155171410 crossrefType "journal-article" @default.
• W2155171410 hasAuthorship W2155171410A5002299630 @default.
• W2155171410 hasAuthorship W2155171410A5019443689 @default.
• W2155171410 hasConcept C119128265 @default.
• W2155171410 hasConcept C178790620 @default.
• W2155171410 hasConcept C179998833 @default.
• W2155171410 hasConcept C185592680 @default.
• W2155171410 hasConcept C2777477808 @default.
• W2155171410 hasConcept C2777879272 @default.
• W2155171410 hasConcept C2780026642 @default.
• W2155171410 hasConcept C43617362 @default.
• W2155171410 hasConcept C4725764 @default.
• W2155171410 hasConcept C55493867 @default.
• W2155171410 hasConcept C73826308 @default.
• W2155171410 hasConceptScore W2155171410C119128265 @default.
• W2155171410 hasConceptScore W2155171410C178790620 @default.
• W2155171410 hasConceptScore W2155171410C179998833 @default.
• W2155171410 hasConceptScore W2155171410C185592680 @default.
• W2155171410 hasConceptScore W2155171410C2777477808 @default.
• W2155171410 hasConceptScore W2155171410C2777879272 @default.
• W2155171410 hasConceptScore W2155171410C2780026642 @default.
• W2155171410 hasConceptScore W2155171410C43617362 @default.
• W2155171410 hasConceptScore W2155171410C4725764 @default.
• W2155171410 hasConceptScore W2155171410C55493867 @default.
• W2155171410 hasConceptScore W2155171410C73826308 @default.
• W2155171410 hasIssue "4" @default.
• W2155171410 hasLocation W21551714101 @default.
• W2155171410 hasLocation W21551714102 @default.
• W2155171410 hasOpenAccess W2155171410 @default.
• W2155171410 hasPrimaryLocation W21551714101 @default.
• W2155171410 hasRelatedWork W118183763 @default.
• W2155171410 hasRelatedWork W1970888742 @default.
• W2155171410 hasRelatedWork W2008727242 @default.
• W2155171410 hasRelatedWork W2035747744 @default.
• W2155171410 hasRelatedWork W2047405359 @default.
• W2155171410 hasRelatedWork W2067605410 @default.
• W2155171410 hasRelatedWork W2107750257 @default.
• W2155171410 hasRelatedWork W2323037448 @default.
• W2155171410 hasRelatedWork W2361213404 @default.
• W2155171410 hasRelatedWork W2406364491 @default.
• W2155171410 hasVolume "74" @default.
• W2155171410 isParatext "false" @default.
• W2155171410 isRetracted "false" @default.
• W2155171410 magId "2155171410" @default.
• W2155171410 workType "article" @default.