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• W2155182414 abstract "A reversed-phase liquid chromatography (RP-LC) method is validated for the determination of aliskiren in tablet dosage form. The LC method is carried out on a Waters XBridge C18 column (150 × 4.6 mm i.d.), maintained at 25°C. The mobile phase consisted of acetonitrile:water (95:5, v/v)/phosphoric acid (25 mM, pH 3.0) (40:60, v/v), run at a flow rate of 1.0 mL/min, with photodiode array detector set at 229 nm. The chromatographic separation is obtained with aliskiren retention time of 3.68 min, and it is linear in the range of 10–300 µg/mL (r = 0.9999). The limits of detection and quantitation are 2.38 and 7.93 µg/mL, respectively. The specificity and stability-indicating capability of the method are proven through degradation studies, which also showed that there is no interference of the formulation excipients, showing that peak is free from any coeluting peak. The method showed adequate precision, with a relative standard deviation (RSD) values lower than 0.92%. Good values of accuracy were also obtained, with a mean value of 99.55%. Experimental design is used during validation to calculate method robustness. The proposed method is applied for the analysis of the tablet dosage forms, contributing to improve the quality control and to assure the therapeutic efficacy." @default.
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• W2155182414 date "2011-02-01" @default.
• W2155182414 modified "2023-09-25" @default.
• W2155182414 title "Determination of Aliskiren in Tablet Dosage Forms by a Validated Stability-indicating RP-LC Method" @default.
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• W2155182414 doi "https://doi.org/10.1093/chrsci/49.2.170" @default.
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