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• W2155183776 abstract "The anti-CD20 antibody rituximab has been reported to induce a heterogeneous spectrum of lung disorders. The aim of the present study was to critically review data on the clinical presentations, causality assessments and management strategies of lung diseases possibly related to rituximab. A systematic literature review was performed on English-language reports in PubMed until September 2008. Cases of lung diseases ascribed to rituximab (n = 45) were identified, with three time-to-onset patterns. The most common presentation was acute/subacute hypoxaemic organising pneumonia (n = 37), starting 2 weeks after the last infusion (often around the fourth cycle) and resolving, in most cases, provided glucocorticoid therapy was given early. Acute respiratory distress syndrome occurred in five patients, within a few hours and usually after the first infusion. In the remaining three patients, macronodular organising pneumonia developed insidiously long after rituximab therapy and responded to steroids. Eight patients died. Based on time to onset, symptoms, and responses to discontinuation and rechallenge with rituximab and other drugs, 13 cases were highly compatible and 32 compatible with rituximab-induced lung disease. Knowledge of these presentations of rituximab-induced lung disease should prove helpful for diagnosis and causality assessment purposes. Time-to-onset data, suggesting different pathogenic mechanisms, support closer clinical and perhaps radiological monitoring between infusions, particularly in patients with a history of reversible respiratory symptoms." @default.
• W2155183776 created "2016-06-24" @default.
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• W2155183776 date "2009-07-16" @default.
• W2155183776 modified "2023-10-18" @default.
• W2155183776 title "Rituximab-induced lung disease: a systematic literature review" @default.
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• W2155183776 doi "https://doi.org/10.1183/09031936.00080209" @default.
• W2155183776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19608586" @default.
• W2155183776 hasPublicationYear "2009" @default.
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