FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155184477> ?p ?o ?g. }

• W2155184477 endingPage "1685" @default.
• W2155184477 startingPage "1677" @default.
• W2155184477 abstract "Lectinlike oxidized low-density lipoprotein (LDL) receptor 1 (LOX-1), a cell surface receptor for oxidized LDL, has been implicated in vascular cell dysfunction related to plaque instability, which could be a potential target for an atherosclerosis imaging tracer. In this study, we designed and prepared ^99mTc-labeled anti–LOX-1 monoclonal IgG and investigated its usefulness as an atherosclerosis imaging agent. <b>Methods:</b> Anti–LOX-1 monoclonal IgG and control mouse IgG2a were labeled with ^99mTc after derivatization with 6-hydrazinonicotinic acid to yield ^99mTc-LOX-1-mAb and ^99mTc-IgG2a, respectively. Myocardial infarction–prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits (atherosclerosis model) and control rabbits were injected intravenously with these probes, and in vivo planar imaging was performed. At 24 h after the injection, the aortas were removed, and radioactivity was measured. Autoradiography and histologic studies were performed with serial aortic sections. <b>Results:</b> The level of ^99mTc-LOX-1-mAb accumulation was 2.0-fold higher than the level of ^99mTc-IgG2a accumulation in WHHLMI rabbit aortas, and the level of ^99mTc-LOX-1-mAb accumulation in WHHLMI rabbit aortas was 10.0-fold higher than the level of ^99mTc-LOX-1-mAb accumulation in control rabbit aortas. In vivo imaging clearly visualized the atherosclerotic aortas of WHHLMI rabbits. Autoradiography and histologic studies revealed that regional ^99mTc-IgG2a accumulation was independent of the histologic grade of the lesions; however, regional ^99mTc-LOX-1-mAb accumulation was significantly correlated with LOX-1 expression density and the vulnerability index. The highest level of ^99mTc-LOX-1-mAb accumulation, expressed as {radioactivity in region of interest (Bq/mm²)/[injected radioactivity (Bq)/animal body weight (g)]} × 10², was found in atheromatous lesions (3.8 ± 1.1 [mean ± SD]), followed in decreasing order by fibroatheromatous lesions (2.0 ± 1.0), collagen-rich lesions (1.6 ± 0.8), and neointimal lesions (1.4 ± 0.7). <b>Conclusion:</b> The level of ^99mTc-LOX-1-mAb accumulation in grade IV atheroma was higher than that in neointimal lesions or other, more stable lesions. Nuclear imaging of LOX-1 expression with ^99mTc-LOX-1-mAb may be a useful means for predicting atheroma at high risk for rupture." @default.
• W2155184477 created "2016-06-24" @default.
• W2155184477 creator A5008055536 @default.
• W2155184477 creator A5008841586 @default.
• W2155184477 creator A5009867090 @default.
• W2155184477 creator A5023348106 @default.
• W2155184477 creator A5029496791 @default.
• W2155184477 creator A5044131429 @default.
• W2155184477 creator A5054317005 @default.
• W2155184477 creator A5056400063 @default.
• W2155184477 creator A5075433231 @default.
• W2155184477 creator A5075639265 @default.
• W2155184477 creator A5088981771 @default.
• W2155184477 date "2008-09-15" @default.
• W2155184477 modified "2023-10-16" @default.
• W2155184477 title "Targeting of Lectinlike Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) with ^99mTc-Labeled Anti–LOX-1 Antibody: Potential Agent for Imaging of Vulnerable Plaque" @default.
• W2155184477 cites W1519345473 @default.
• W2155184477 cites W1969492846 @default.
• W2155184477 cites W1971847174 @default.
• W2155184477 cites W1980842943 @default.
• W2155184477 cites W1985360214 @default.
• W2155184477 cites W1989091022 @default.
• W2155184477 cites W1994916925 @default.
• W2155184477 cites W1998464760 @default.
• W2155184477 cites W2001588821 @default.
• W2155184477 cites W2006424510 @default.
• W2155184477 cites W2009808076 @default.
• W2155184477 cites W2038520392 @default.
• W2155184477 cites W2039344988 @default.
• W2155184477 cites W2044819093 @default.
• W2155184477 cites W2053646512 @default.
• W2155184477 cites W2073751205 @default.
• W2155184477 cites W2075951998 @default.
• W2155184477 cites W2078027003 @default.
• W2155184477 cites W2082558448 @default.
• W2155184477 cites W2099365062 @default.
• W2155184477 cites W2107390943 @default.
• W2155184477 cites W2107784979 @default.
• W2155184477 cites W2113324937 @default.
• W2155184477 cites W2115268091 @default.
• W2155184477 cites W2121639380 @default.
• W2155184477 cites W2124598893 @default.
• W2155184477 cites W2145712428 @default.
• W2155184477 cites W2148706200 @default.
• W2155184477 cites W2160094856 @default.
• W2155184477 cites W2031143051 @default.
• W2155184477 doi "https://doi.org/10.2967/jnumed.107.049536" @default.
• W2155184477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18794262" @default.
• W2155184477 hasPublicationYear "2008" @default.
• W2155184477 type Work @default.
• W2155184477 sameAs 2155184477 @default.
• W2155184477 citedByCount "85" @default.
• W2155184477 countsByYear W21551844772012 @default.
• W2155184477 countsByYear W21551844772013 @default.
• W2155184477 countsByYear W21551844772014 @default.
• W2155184477 countsByYear W21551844772015 @default.
• W2155184477 countsByYear W21551844772016 @default.
• W2155184477 countsByYear W21551844772017 @default.
• W2155184477 countsByYear W21551844772018 @default.
• W2155184477 countsByYear W21551844772019 @default.
• W2155184477 countsByYear W21551844772020 @default.
• W2155184477 countsByYear W21551844772022 @default.
• W2155184477 countsByYear W21551844772023 @default.
• W2155184477 crossrefType "journal-article" @default.
• W2155184477 hasAuthorship W2155184477A5008055536 @default.
• W2155184477 hasAuthorship W2155184477A5008841586 @default.
• W2155184477 hasAuthorship W2155184477A5009867090 @default.
• W2155184477 hasAuthorship W2155184477A5023348106 @default.
• W2155184477 hasAuthorship W2155184477A5029496791 @default.
• W2155184477 hasAuthorship W2155184477A5044131429 @default.
• W2155184477 hasAuthorship W2155184477A5054317005 @default.
• W2155184477 hasAuthorship W2155184477A5056400063 @default.
• W2155184477 hasAuthorship W2155184477A5075433231 @default.
• W2155184477 hasAuthorship W2155184477A5075639265 @default.
• W2155184477 hasAuthorship W2155184477A5088981771 @default.
• W2155184477 hasBestOaLocation W21551844771 @default.
• W2155184477 hasConcept C150903083 @default.
• W2155184477 hasConcept C185592680 @default.
• W2155184477 hasConcept C207001950 @default.
• W2155184477 hasConcept C86803240 @default.
• W2155184477 hasConceptScore W2155184477C150903083 @default.
• W2155184477 hasConceptScore W2155184477C185592680 @default.
• W2155184477 hasConceptScore W2155184477C207001950 @default.
• W2155184477 hasConceptScore W2155184477C86803240 @default.
• W2155184477 hasIssue "10" @default.
• W2155184477 hasLocation W21551844771 @default.
• W2155184477 hasLocation W21551844772 @default.
• W2155184477 hasOpenAccess W2155184477 @default.
• W2155184477 hasPrimaryLocation W21551844771 @default.
• W2155184477 hasRelatedWork W1531601525 @default.
• W2155184477 hasRelatedWork W2319480705 @default.
• W2155184477 hasRelatedWork W2384464875 @default.
• W2155184477 hasRelatedWork W2398689458 @default.
• W2155184477 hasRelatedWork W2606230654 @default.
• W2155184477 hasRelatedWork W2607424097 @default.
• W2155184477 hasRelatedWork W2748952813 @default.
• W2155184477 hasRelatedWork W2899084033 @default.
• W2155184477 hasRelatedWork W2948807893 @default.

• next