FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155196975> ?p ?o ?g. }

• W2155196975 endingPage "394" @default.
• W2155196975 startingPage "387" @default.
• W2155196975 abstract "The endothelial protein C receptor plays an important role within the protein C pathway in regulating coagulation and inflammation. Recently, we described that endothelial protein C receptor can be released in vitro in microparticulate form from primary endothelial cells by exogenous activated protein C. Activated protein C bound to this endothelial protein C receptor retains anticoagulant activity and we hypothesize that this microparticulate endothelial protein C receptor-activated protein C complex can also cleave endothelial protease-activated receptor 1 to modulate inflammation and increase cell survival. Our main objective was, therefore, to study the effect that microparticle-associated endothelial protein C receptor-activated protein C has on endothelial function.Mini-arrays were used and probed with cDNA obtained from endothelial cells after treatment with microparticle-associated endothelial protein C receptor-activated protein C and results were confirmed by real time polymerase chain reaction. The functional relevance of changes at gene level were further analyzed by endothelial apoptosis and permeability assays, in the presence and absence of specific blockade of endothelial protein C receptor, protein C and protease-activated receptor 1.Gene profiling of endothelial cells stimulated by 40 nmol/L activated protein C on microparticles showed significant changes in anti-apoptotic and inflammatory pathways. This was accompanied by protease-activated receptor 1-dependent anti-apoptotic and barrier protective effects, the latter of which also involved sphingosine 1-phosphate receptor and vascular endothelial growth factor receptor-2/ kinase insert domain receptor. Protein C blockade reversed these effects showing specificity for activated protein C on microparticles. Furthermore, confocal microscopy and enzyme-linked immunosorbent assay of plasma obtained from septic patients during recombinant activated protein C treatment showed evidence of their presence in vivo.Activated protein C on microparticle-associated endothelial protein C receptor release can induce protease-activated receptor 1-dependent endothelial effects. The mechanisms underlying barrier protection involve sphingosine 1-phosphate receptor and kinase insert domain receptor." @default.
• W2155196975 created "2016-06-24" @default.
• W2155196975 creator A5005068597 @default.
• W2155196975 creator A5026332836 @default.
• W2155196975 creator A5030653175 @default.
• W2155196975 creator A5039772474 @default.
• W2155196975 creator A5068611314 @default.
• W2155196975 creator A5069544192 @default.
• W2155196975 date "2009-03-01" @default.
• W2155196975 modified "2023-10-01" @default.
• W2155196975 title "Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects" @default.
• W2155196975 cites W1570103822 @default.
• W2155196975 cites W1727122499 @default.
• W2155196975 cites W1969909530 @default.
• W2155196975 cites W1972365386 @default.
• W2155196975 cites W1982099387 @default.
• W2155196975 cites W1984849676 @default.
• W2155196975 cites W1991183471 @default.
• W2155196975 cites W1993601122 @default.
• W2155196975 cites W2000985786 @default.
• W2155196975 cites W2002603960 @default.
• W2155196975 cites W2009146389 @default.
• W2155196975 cites W2016145118 @default.
• W2155196975 cites W2026106674 @default.
• W2155196975 cites W2035451122 @default.
• W2155196975 cites W2040968233 @default.
• W2155196975 cites W2050569979 @default.
• W2155196975 cites W2065227956 @default.
• W2155196975 cites W2065408869 @default.
• W2155196975 cites W2065950908 @default.
• W2155196975 cites W2075276667 @default.
• W2155196975 cites W2077049963 @default.
• W2155196975 cites W2084757096 @default.
• W2155196975 cites W2086968965 @default.
• W2155196975 cites W2092311768 @default.
• W2155196975 cites W2103083564 @default.
• W2155196975 cites W2125943680 @default.
• W2155196975 cites W2147116051 @default.
• W2155196975 cites W2171715330 @default.
• W2155196975 cites W2322121630 @default.
• W2155196975 cites W2768146862 @default.
• W2155196975 doi "https://doi.org/10.3324/haematol.13547" @default.
• W2155196975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2649352" @default.
• W2155196975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19211643" @default.
• W2155196975 hasPublicationYear "2009" @default.
• W2155196975 type Work @default.
• W2155196975 sameAs 2155196975 @default.
• W2155196975 citedByCount "82" @default.
• W2155196975 countsByYear W21551969752012 @default.
• W2155196975 countsByYear W21551969752013 @default.
• W2155196975 countsByYear W21551969752014 @default.
• W2155196975 countsByYear W21551969752015 @default.
• W2155196975 countsByYear W21551969752016 @default.
• W2155196975 countsByYear W21551969752017 @default.
• W2155196975 countsByYear W21551969752018 @default.
• W2155196975 countsByYear W21551969752019 @default.
• W2155196975 countsByYear W21551969752020 @default.
• W2155196975 countsByYear W21551969752021 @default.
• W2155196975 countsByYear W21551969752022 @default.
• W2155196975 countsByYear W21551969752023 @default.
• W2155196975 crossrefType "journal-article" @default.
• W2155196975 hasAuthorship W2155196975A5005068597 @default.
• W2155196975 hasAuthorship W2155196975A5026332836 @default.
• W2155196975 hasAuthorship W2155196975A5030653175 @default.
• W2155196975 hasAuthorship W2155196975A5039772474 @default.
• W2155196975 hasAuthorship W2155196975A5068611314 @default.
• W2155196975 hasAuthorship W2155196975A5069544192 @default.
• W2155196975 hasBestOaLocation W21551969751 @default.
• W2155196975 hasConcept C123012128 @default.
• W2155196975 hasConcept C125268873 @default.
• W2155196975 hasConcept C140800825 @default.
• W2155196975 hasConcept C146285616 @default.
• W2155196975 hasConcept C149577978 @default.
• W2155196975 hasConcept C150710994 @default.
• W2155196975 hasConcept C153911025 @default.
• W2155196975 hasConcept C167734588 @default.
• W2155196975 hasConcept C170493617 @default.
• W2155196975 hasConcept C17971392 @default.
• W2155196975 hasConcept C185592680 @default.
• W2155196975 hasConcept C202751555 @default.
• W2155196975 hasConcept C203014093 @default.
• W2155196975 hasConcept C2776816377 @default.
• W2155196975 hasConcept C2777025900 @default.
• W2155196975 hasConcept C2777292125 @default.
• W2155196975 hasConcept C502942594 @default.
• W2155196975 hasConcept C55493867 @default.
• W2155196975 hasConcept C86803240 @default.
• W2155196975 hasConcept C89560881 @default.
• W2155196975 hasConcept C95444343 @default.
• W2155196975 hasConceptScore W2155196975C123012128 @default.
• W2155196975 hasConceptScore W2155196975C125268873 @default.
• W2155196975 hasConceptScore W2155196975C140800825 @default.
• W2155196975 hasConceptScore W2155196975C146285616 @default.
• W2155196975 hasConceptScore W2155196975C149577978 @default.
• W2155196975 hasConceptScore W2155196975C150710994 @default.
• W2155196975 hasConceptScore W2155196975C153911025 @default.
• W2155196975 hasConceptScore W2155196975C167734588 @default.
• W2155196975 hasConceptScore W2155196975C170493617 @default.

• next