FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155200107> ?p ?o ?g. }

• W2155200107 endingPage "2053" @default.
• W2155200107 startingPage "2046" @default.
• W2155200107 abstract "This study explored the tissue-protective properties of the continuous erythropoietin receptor activator (CERA) in an experimental model of (nonischemic) diabetic kidney injury (i.e., the db/db mouse). Mice were randomly treated with placebo (n = 25), low-dosage CERA (n = 25), and high-dosage CERA (n = 25). Also studied were 25 nondiabetic db/m mice. Hematocrit was comparable in placebo and low-dosage CERA–treated mice but increased significantly with high-dosage CERA (P < 0.01 versus both). Significantly reduced expression of TGF-β, vascular endothelial growth factor, and collagen IV was found in glomeruli and the tubulointerstitial area with CERA treatment, and these beneficial molecular effects were clearly dosage dependent (both P < 0.05 versus placebo). Similarly, CERA treatment caused a dosage-dependent increase in p-Akt, nephrin, and perlecan tissue expression (all P < 0.05 versus placebo). However, the accelerated mesangial expansion that was observed in placebo-treated db/db mice (versus db/m controls) was significantly reduced only in low-dosage CERA–treated mice (P < 0.01). Moreover, albuminuria was significantly reduced in low- but not high-dosage CERA–treated mice compared with placebo treatment (P < 0.05). In an ancillary study, phlebotomy was performed in high-dosage CERA–treated db/db mice to keep hematocrit within normal (baseline) levels. This procedure resulted in significantly (P < 0.05) less albuminuria as compared with high-dosage CERA–treated mice without phlebotomy, thus preserving the tissue-protective potential of CERA. Long-term CERA treatment has beneficial dosage-dependent effects on molecular pathways of diabetic kidney damage. Low-dosage CERA does not affect hematocrit and therefore may be a feasible method of tissue protection in this setting." @default.
• W2155200107 created "2016-06-24" @default.
• W2155200107 creator A5012419218 @default.
• W2155200107 creator A5023168693 @default.
• W2155200107 creator A5042237095 @default.
• W2155200107 creator A5046399162 @default.
• W2155200107 creator A5053507788 @default.
• W2155200107 creator A5083723682 @default.
• W2155200107 date "2007-07-01" @default.
• W2155200107 modified "2023-09-25" @default.
• W2155200107 title "The Continuous Erythropoietin Receptor Activator Affects Different Pathways of Diabetic Renal Injury" @default.
• W2155200107 cites W170849090 @default.
• W2155200107 cites W1877534135 @default.
• W2155200107 cites W1974106801 @default.
• W2155200107 cites W2001892266 @default.
• W2155200107 cites W2016865792 @default.
• W2155200107 cites W2032710106 @default.
• W2155200107 cites W2032950904 @default.
• W2155200107 cites W2035076162 @default.
• W2155200107 cites W2039171731 @default.
• W2155200107 cites W2040029744 @default.
• W2155200107 cites W2049276892 @default.
• W2155200107 cites W2063579084 @default.
• W2155200107 cites W2077811405 @default.
• W2155200107 cites W2081820417 @default.
• W2155200107 cites W2083568114 @default.
• W2155200107 cites W2087367592 @default.
• W2155200107 cites W2091425669 @default.
• W2155200107 cites W2091754751 @default.
• W2155200107 cites W2099365070 @default.
• W2155200107 cites W2101417448 @default.
• W2155200107 cites W2107661284 @default.
• W2155200107 cites W2109674240 @default.
• W2155200107 cites W2113664327 @default.
• W2155200107 cites W2114200426 @default.
• W2155200107 cites W2133198522 @default.
• W2155200107 cites W2134487085 @default.
• W2155200107 cites W2151105728 @default.
• W2155200107 cites W2154685498 @default.
• W2155200107 cites W2155261780 @default.
• W2155200107 cites W2160713807 @default.
• W2155200107 cites W2165325650 @default.
• W2155200107 cites W2170023789 @default.
• W2155200107 doi "https://doi.org/10.1681/asn.2006070699" @default.
• W2155200107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17554150" @default.
• W2155200107 hasPublicationYear "2007" @default.
• W2155200107 type Work @default.
• W2155200107 sameAs 2155200107 @default.
• W2155200107 citedByCount "46" @default.
• W2155200107 countsByYear W21552001072012 @default.
• W2155200107 countsByYear W21552001072013 @default.
• W2155200107 countsByYear W21552001072014 @default.
• W2155200107 countsByYear W21552001072016 @default.
• W2155200107 countsByYear W21552001072017 @default.
• W2155200107 countsByYear W21552001072018 @default.
• W2155200107 countsByYear W21552001072019 @default.
• W2155200107 countsByYear W21552001072020 @default.
• W2155200107 countsByYear W21552001072021 @default.
• W2155200107 crossrefType "journal-article" @default.
• W2155200107 hasAuthorship W2155200107A5012419218 @default.
• W2155200107 hasAuthorship W2155200107A5023168693 @default.
• W2155200107 hasAuthorship W2155200107A5042237095 @default.
• W2155200107 hasAuthorship W2155200107A5046399162 @default.
• W2155200107 hasAuthorship W2155200107A5053507788 @default.
• W2155200107 hasAuthorship W2155200107A5083723682 @default.
• W2155200107 hasBestOaLocation W21552001071 @default.
• W2155200107 hasConcept C126322002 @default.
• W2155200107 hasConcept C134018914 @default.
• W2155200107 hasConcept C142724271 @default.
• W2155200107 hasConcept C204787440 @default.
• W2155200107 hasConcept C27081682 @default.
• W2155200107 hasConcept C2776174234 @default.
• W2155200107 hasConcept C2778534260 @default.
• W2155200107 hasConcept C2780091579 @default.
• W2155200107 hasConcept C2780959883 @default.
• W2155200107 hasConcept C71924100 @default.
• W2155200107 hasConceptScore W2155200107C126322002 @default.
• W2155200107 hasConceptScore W2155200107C134018914 @default.
• W2155200107 hasConceptScore W2155200107C142724271 @default.
• W2155200107 hasConceptScore W2155200107C204787440 @default.
• W2155200107 hasConceptScore W2155200107C27081682 @default.
• W2155200107 hasConceptScore W2155200107C2776174234 @default.
• W2155200107 hasConceptScore W2155200107C2778534260 @default.
• W2155200107 hasConceptScore W2155200107C2780091579 @default.
• W2155200107 hasConceptScore W2155200107C2780959883 @default.
• W2155200107 hasConceptScore W2155200107C71924100 @default.
• W2155200107 hasIssue "7" @default.
• W2155200107 hasLocation W21552001071 @default.
• W2155200107 hasLocation W21552001072 @default.
• W2155200107 hasLocation W21552001073 @default.
• W2155200107 hasOpenAccess W2155200107 @default.
• W2155200107 hasPrimaryLocation W21552001071 @default.
• W2155200107 hasRelatedWork W2042033030 @default.
• W2155200107 hasRelatedWork W2098830437 @default.
• W2155200107 hasRelatedWork W2126063009 @default.
• W2155200107 hasRelatedWork W2127085070 @default.
• W2155200107 hasRelatedWork W2137584496 @default.
• W2155200107 hasRelatedWork W2141708039 @default.

• next