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• W2155200939 abstract "Aim: The diagnosis of biliary atresia (BA) is challenging as no single preoperative test is 100% accurate, especially for distinguishing it from other causes of neonatal cholestasis (NC). Intercellular adhesion molecule (ICAM) elevation was reported in BA as a part of the immune‐mediated inflammatory process. The use of ICAM‐1 as a discriminative tool between BA and other causes of NC has never been addressed before. This study was to evaluate the diagnostic potentials of ICAM‐1 in BA versus other forms of NC. Methods: For this purpose, serum ICAM‐1 (sICAM‐1) and ICAM‐1 expression, in liver biopsy using immunohistochemistry, were estimated in 30 patients with BA and compared to that in 20 patients with other forms of NC. sICAM‐1 levels were compared to that in 20 healthy controls. Results: sICAM‐1 levels were significantly higher in BA (1055.9 ± 230.2 ng/mL) than that in cholestasis (604.8 ± 194.8 ng/mL) and the control groups (158.9 ± 78.7 ng/mL) ( P < 0.0001). A cut‐off value of 793.8 ng/mL had 86.7% sensitivity and 95% specificity in discriminating the BA from the cholestasis group. The biliary expression score of ICAM‐1 at a cut‐off value of 110 could discriminate between BA and other causes of NC with 100% sensitivity and specificity. Neither serum levels nor liver expression of ICAM‐1 scores correlated with disease severity or with fibrosis stage. Conclusion: These results suggest that ICAM‐1 has a diagnostic value in patients with BA and would be a promising helpful tool when investigating patients with NC." @default.
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• W2155200939 date "2011-07-24" @default.
• W2155200939 modified "2023-10-17" @default.
• W2155200939 title "Diagnostic value of hepatic intercellular adhesion molecule-1 expression in Egyptian infants with biliary atresia and other forms of neonatal cholestasis" @default.
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• W2155200939 doi "https://doi.org/10.1111/j.1872-034x.2011.00832.x" @default.
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