FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155201767> ?p ?o ?g. }

• W2155201767 endingPage "3294" @default.
• W2155201767 startingPage "3285" @default.
• W2155201767 abstract "Sly disease (MPS VII) is an autosomal-recessive lysosomal storage disorder resulting from beta-glucuronidase deficiency, which is characterized by a severe neurological impairment. MPS VII mice accumulate undegraded glycosaminoglycans and mimic the human neurodegenerative disorder, thus appearing to be an excellent tool to delineate disease pathogenesis. The relationship between abnormal glycosaminoglycan storage and neurodysfunction is not yet well understood, but inflammatory components can be involved, as in several neurological lysosomal disorders. Inflammatory biomarkers are thus good candidates to evaluate the neurodegeneration state of the disease. By using quantitative polymerase chain reaction, we have compared the expression of selected genes of normal and MPS VII cerebral tissues, focusing on inflammation and apoptosis-related genes. The gene expression was evaluated in various brain regions throughout the lifetime of the animals. We have identified a specific expression profile for 27 genes, which was strongly marked in the central nervous system posterior region. Finally, new Sly disease markers were characterized that reflect neurological deterioration state, and that can be used in preclinical follow-up studies." @default.
• W2155201767 created "2016-06-24" @default.
• W2155201767 creator A5005559535 @default.
• W2155201767 creator A5039891090 @default.
• W2155201767 creator A5050044807 @default.
• W2155201767 creator A5068423684 @default.
• W2155201767 creator A5080596509 @default.
• W2155201767 date "2008-11-15" @default.
• W2155201767 modified "2023-10-05" @default.
• W2155201767 title "Identification of new markers for neurodegeneration process in the mouse model of Sly disease as revealed by expression profiling of selected genes" @default.
• W2155201767 cites W1482686873 @default.
• W2155201767 cites W1611449349 @default.
• W2155201767 cites W1894006267 @default.
• W2155201767 cites W1972420702 @default.
• W2155201767 cites W1974003614 @default.
• W2155201767 cites W1982768578 @default.
• W2155201767 cites W1999684167 @default.
• W2155201767 cites W2002593000 @default.
• W2155201767 cites W2008944418 @default.
• W2155201767 cites W2016140784 @default.
• W2155201767 cites W2021977327 @default.
• W2155201767 cites W2037373871 @default.
• W2155201767 cites W2037490639 @default.
• W2155201767 cites W2043642541 @default.
• W2155201767 cites W2048082637 @default.
• W2155201767 cites W2059827622 @default.
• W2155201767 cites W2062994385 @default.
• W2155201767 cites W2067064831 @default.
• W2155201767 cites W2073304593 @default.
• W2155201767 cites W2076097077 @default.
• W2155201767 cites W2078581371 @default.
• W2155201767 cites W2080911273 @default.
• W2155201767 cites W2084761937 @default.
• W2155201767 cites W2107178973 @default.
• W2155201767 cites W2115064726 @default.
• W2155201767 cites W2122810522 @default.
• W2155201767 cites W2124796361 @default.
• W2155201767 cites W2128541330 @default.
• W2155201767 cites W2130892977 @default.
• W2155201767 cites W2137973944 @default.
• W2155201767 cites W2161238216 @default.
• W2155201767 cites W2162633850 @default.
• W2155201767 cites W2163247992 @default.
• W2155201767 cites W2166670696 @default.
• W2155201767 cites W2168626405 @default.
• W2155201767 doi "https://doi.org/10.1002/jnr.21779" @default.
• W2155201767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18646207" @default.
• W2155201767 hasPublicationYear "2008" @default.
• W2155201767 type Work @default.
• W2155201767 sameAs 2155201767 @default.
• W2155201767 citedByCount "19" @default.
• W2155201767 countsByYear W21552017672012 @default.
• W2155201767 countsByYear W21552017672013 @default.
• W2155201767 countsByYear W21552017672014 @default.
• W2155201767 countsByYear W21552017672016 @default.
• W2155201767 countsByYear W21552017672018 @default.
• W2155201767 countsByYear W21552017672020 @default.
• W2155201767 countsByYear W21552017672023 @default.
• W2155201767 crossrefType "journal-article" @default.
• W2155201767 hasAuthorship W2155201767A5005559535 @default.
• W2155201767 hasAuthorship W2155201767A5039891090 @default.
• W2155201767 hasAuthorship W2155201767A5050044807 @default.
• W2155201767 hasAuthorship W2155201767A5068423684 @default.
• W2155201767 hasAuthorship W2155201767A5080596509 @default.
• W2155201767 hasConcept C104317684 @default.
• W2155201767 hasConcept C142724271 @default.
• W2155201767 hasConcept C150194340 @default.
• W2155201767 hasConcept C18431079 @default.
• W2155201767 hasConcept C203014093 @default.
• W2155201767 hasConcept C2776914184 @default.
• W2155201767 hasConcept C2776925932 @default.
• W2155201767 hasConcept C2779134260 @default.
• W2155201767 hasConcept C2780942790 @default.
• W2155201767 hasConcept C54355233 @default.
• W2155201767 hasConcept C71924100 @default.
• W2155201767 hasConcept C86803240 @default.
• W2155201767 hasConceptScore W2155201767C104317684 @default.
• W2155201767 hasConceptScore W2155201767C142724271 @default.
• W2155201767 hasConceptScore W2155201767C150194340 @default.
• W2155201767 hasConceptScore W2155201767C18431079 @default.
• W2155201767 hasConceptScore W2155201767C203014093 @default.
• W2155201767 hasConceptScore W2155201767C2776914184 @default.
• W2155201767 hasConceptScore W2155201767C2776925932 @default.
• W2155201767 hasConceptScore W2155201767C2779134260 @default.
• W2155201767 hasConceptScore W2155201767C2780942790 @default.
• W2155201767 hasConceptScore W2155201767C54355233 @default.
• W2155201767 hasConceptScore W2155201767C71924100 @default.
• W2155201767 hasConceptScore W2155201767C86803240 @default.
• W2155201767 hasIssue "15" @default.
• W2155201767 hasLocation W21552017671 @default.
• W2155201767 hasLocation W21552017672 @default.
• W2155201767 hasOpenAccess W2155201767 @default.
• W2155201767 hasPrimaryLocation W21552017671 @default.
• W2155201767 hasRelatedWork W104645380 @default.
• W2155201767 hasRelatedWork W2017047508 @default.
• W2155201767 hasRelatedWork W2023641020 @default.
• W2155201767 hasRelatedWork W2027213253 @default.
• W2155201767 hasRelatedWork W2041199873 @default.

• next