Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155215427> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2155215427 endingPage "676" @default.
- W2155215427 startingPage "669" @default.
- W2155215427 abstract "An in vitro system has been established in which conversion from non-metastasizing to metastasizing adenocarcinoma cells can be induced, and subsequently subjected to analysis of the expression of proteases and tissue inhibitor of metalloproteinases-1 (TIMP-1). A human salivary-gland adenocarcinoma cell clone HSGc, with no metastatic ability, was exposed to N-methyl-N-nitrosourea (MNU). Following exposure to MNU, cells with altered morphology were cloned. Upon s.c. inoculation into nude mice, MNU-treated HSGc clones formed metastatic foci in various organs, and then 5 metastasizing clones were isolated. Evaluation of expression of tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), metalloproteinases and TIMP-1 was performed by means of enzyme immunoassay, zymogram, or immunoblot. MNU-treated HSGc and metastasizing clones were found to secrete high levels of tPA, while HSGc produced undetectable levels of this enzyme. Expression of uPA was not observed in any of the cell clones. When the secretion of gelatinolytic enzymes was examined, metastasizing clones produced higher levels of 57- and 32-kDa, but not of 92- or 72-kDa gelatinases, as compared to HSGc cells. Although TIMP-1 was detected in all cell clones, metastasizing clones secreted less TIMP-1 than HSGc cells; in addition, one metastasizing clone produced TIMP-1 with a molecular weight distinct from that of 28-kDa TIMP-1. Our results suggest that the acquisition of metastatic ability by human salivary-gland tumor cells is closely associated with increased secretion of several metalloproteinases as well as decreased or altered TIMP-1 expression." @default.
- W2155215427 created "2016-06-24" @default.
- W2155215427 creator A5024888646 @default.
- W2155215427 creator A5032263781 @default.
- W2155215427 creator A5039382906 @default.
- W2155215427 creator A5044297659 @default.
- W2155215427 creator A5060323942 @default.
- W2155215427 creator A5065935727 @default.
- W2155215427 creator A5077883017 @default.
- W2155215427 creator A5081643605 @default.
- W2155215427 date "1993-06-19" @default.
- W2155215427 modified "2023-09-26" @default.
- W2155215427 title "Role of plasminogen activators, metalloproteinases and the tissue inhibitor of metalloproteinase-1 in the metastatic process of human salivary-gland adenocarcinoma cells" @default.
- W2155215427 cites W1965918539 @default.
- W2155215427 cites W1968241250 @default.
- W2155215427 cites W1980480613 @default.
- W2155215427 cites W2017843133 @default.
- W2155215427 cites W2021198425 @default.
- W2155215427 cites W2063450941 @default.
- W2155215427 cites W2064831203 @default.
- W2155215427 cites W2068922572 @default.
- W2155215427 cites W2075439988 @default.
- W2155215427 cites W2077483002 @default.
- W2155215427 cites W2100837269 @default.
- W2155215427 cites W2124325733 @default.
- W2155215427 doi "https://doi.org/10.1002/ijc.2910540424" @default.
- W2155215427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8514458" @default.
- W2155215427 hasPublicationYear "1993" @default.
- W2155215427 type Work @default.
- W2155215427 sameAs 2155215427 @default.
- W2155215427 citedByCount "25" @default.
- W2155215427 countsByYear W21552154272012 @default.
- W2155215427 crossrefType "journal-article" @default.
- W2155215427 hasAuthorship W2155215427A5024888646 @default.
- W2155215427 hasAuthorship W2155215427A5032263781 @default.
- W2155215427 hasAuthorship W2155215427A5039382906 @default.
- W2155215427 hasAuthorship W2155215427A5044297659 @default.
- W2155215427 hasAuthorship W2155215427A5060323942 @default.
- W2155215427 hasAuthorship W2155215427A5065935727 @default.
- W2155215427 hasAuthorship W2155215427A5077883017 @default.
- W2155215427 hasAuthorship W2155215427A5081643605 @default.
- W2155215427 hasConcept C104317684 @default.
- W2155215427 hasConcept C109523444 @default.
- W2155215427 hasConcept C134018914 @default.
- W2155215427 hasConcept C153911025 @default.
- W2155215427 hasConcept C177430391 @default.
- W2155215427 hasConcept C181199279 @default.
- W2155215427 hasConcept C182220744 @default.
- W2155215427 hasConcept C2776892390 @default.
- W2155215427 hasConcept C2779679481 @default.
- W2155215427 hasConcept C3019223276 @default.
- W2155215427 hasConcept C54355233 @default.
- W2155215427 hasConcept C55493867 @default.
- W2155215427 hasConcept C55728118 @default.
- W2155215427 hasConcept C81089528 @default.
- W2155215427 hasConcept C86803240 @default.
- W2155215427 hasConceptScore W2155215427C104317684 @default.
- W2155215427 hasConceptScore W2155215427C109523444 @default.
- W2155215427 hasConceptScore W2155215427C134018914 @default.
- W2155215427 hasConceptScore W2155215427C153911025 @default.
- W2155215427 hasConceptScore W2155215427C177430391 @default.
- W2155215427 hasConceptScore W2155215427C181199279 @default.
- W2155215427 hasConceptScore W2155215427C182220744 @default.
- W2155215427 hasConceptScore W2155215427C2776892390 @default.
- W2155215427 hasConceptScore W2155215427C2779679481 @default.
- W2155215427 hasConceptScore W2155215427C3019223276 @default.
- W2155215427 hasConceptScore W2155215427C54355233 @default.
- W2155215427 hasConceptScore W2155215427C55493867 @default.
- W2155215427 hasConceptScore W2155215427C55728118 @default.
- W2155215427 hasConceptScore W2155215427C81089528 @default.
- W2155215427 hasConceptScore W2155215427C86803240 @default.
- W2155215427 hasIssue "4" @default.
- W2155215427 hasLocation W21552154271 @default.
- W2155215427 hasLocation W21552154272 @default.
- W2155215427 hasOpenAccess W2155215427 @default.
- W2155215427 hasPrimaryLocation W21552154271 @default.
- W2155215427 hasRelatedWork W170289634 @default.
- W2155215427 hasRelatedWork W1861039783 @default.
- W2155215427 hasRelatedWork W1911418737 @default.
- W2155215427 hasRelatedWork W1978835322 @default.
- W2155215427 hasRelatedWork W2041152068 @default.
- W2155215427 hasRelatedWork W2047960744 @default.
- W2155215427 hasRelatedWork W2079244520 @default.
- W2155215427 hasRelatedWork W2112225579 @default.
- W2155215427 hasRelatedWork W2461630137 @default.
- W2155215427 hasRelatedWork W2782857268 @default.
- W2155215427 hasVolume "54" @default.
- W2155215427 isParatext "false" @default.
- W2155215427 isRetracted "false" @default.
- W2155215427 magId "2155215427" @default.
- W2155215427 workType "article" @default.