Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155238293> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2155238293 abstract "Apoptosis is a self mediated form of cell death that plays a significant role in the growth, development, and well being of multicellular organisms. If this process fails, potentially harmful cells are able to multiply uncontrollably within the organism forming harmful structures such as tumours. Although there are many signals and processes involved that may trigger apoptosis, the Bcl-2 family of proteins find themselves at a bottle neck of many of these pathways, as well as at the point after which the cell is no longer able to abort committing suicide. Bax is such a protein, and upon insertion and oligomerization within the outer mitochondrial membrane of mitochondria, apoptotic factors (such as cytochrome c) are released into the cytoplasm of the cell sealing its fate. Lipid composition is known to affect the process of membrane permeabilization by Bcl-2 family proteins, where different lipid compositions can block the process at different steps. Here we have investigated whether these different effects could be related to structural membrane properties. Solid supported lipid bilayers and aligned bilayer stacks are a convenient model system to study membranes structural properties. Not only do they allow for a rigid macroscopic sample size, they also offer a well defined geometry exploitable through techniques such as atomic force microscopy as well as x-ray and neutron scattering. Through Fourier analysis, we are able to utilize x-ray reflectivity data to analyze the electron density profile perpendicular to the plane of the membranes with sub-Angstrom resolution. We have characterized the structure of a membrane with a lipid composition mimicking that of mitochondrial membranes, and that of a series of membranes slightly differing from this original composition, and known to block the Bcl-2 family proteins pore formation process." @default.
- W2155238293 created "2016-06-24" @default.
- W2155238293 creator A5023965566 @default.
- W2155238293 creator A5046830693 @default.
- W2155238293 creator A5049091362 @default.
- W2155238293 creator A5066158171 @default.
- W2155238293 creator A5070642493 @default.
- W2155238293 creator A5076233641 @default.
- W2155238293 date "2012-01-01" @default.
- W2155238293 modified "2023-09-28" @default.
- W2155238293 title "A Supported Bilayer Model to Study the Effect of Membrane Composition on Bcl-2 Family Proteins" @default.
- W2155238293 doi "https://doi.org/10.1016/j.bpj.2011.11.3522" @default.
- W2155238293 hasPublicationYear "2012" @default.
- W2155238293 type Work @default.
- W2155238293 sameAs 2155238293 @default.
- W2155238293 citedByCount "0" @default.
- W2155238293 crossrefType "journal-article" @default.
- W2155238293 hasAuthorship W2155238293A5023965566 @default.
- W2155238293 hasAuthorship W2155238293A5046830693 @default.
- W2155238293 hasAuthorship W2155238293A5049091362 @default.
- W2155238293 hasAuthorship W2155238293A5066158171 @default.
- W2155238293 hasAuthorship W2155238293A5070642493 @default.
- W2155238293 hasAuthorship W2155238293A5076233641 @default.
- W2155238293 hasBestOaLocation W21552382931 @default.
- W2155238293 hasConcept C12554922 @default.
- W2155238293 hasConcept C168240541 @default.
- W2155238293 hasConcept C185592680 @default.
- W2155238293 hasConcept C190062978 @default.
- W2155238293 hasConcept C192157962 @default.
- W2155238293 hasConcept C28859421 @default.
- W2155238293 hasConcept C39944091 @default.
- W2155238293 hasConcept C41625074 @default.
- W2155238293 hasConcept C55493867 @default.
- W2155238293 hasConcept C8010536 @default.
- W2155238293 hasConcept C86803240 @default.
- W2155238293 hasConcept C95444343 @default.
- W2155238293 hasConceptScore W2155238293C12554922 @default.
- W2155238293 hasConceptScore W2155238293C168240541 @default.
- W2155238293 hasConceptScore W2155238293C185592680 @default.
- W2155238293 hasConceptScore W2155238293C190062978 @default.
- W2155238293 hasConceptScore W2155238293C192157962 @default.
- W2155238293 hasConceptScore W2155238293C28859421 @default.
- W2155238293 hasConceptScore W2155238293C39944091 @default.
- W2155238293 hasConceptScore W2155238293C41625074 @default.
- W2155238293 hasConceptScore W2155238293C55493867 @default.
- W2155238293 hasConceptScore W2155238293C8010536 @default.
- W2155238293 hasConceptScore W2155238293C86803240 @default.
- W2155238293 hasConceptScore W2155238293C95444343 @default.
- W2155238293 hasLocation W21552382931 @default.
- W2155238293 hasOpenAccess W2155238293 @default.
- W2155238293 hasPrimaryLocation W21552382931 @default.
- W2155238293 hasRelatedWork W181485729 @default.
- W2155238293 hasRelatedWork W192287780 @default.
- W2155238293 hasRelatedWork W196557916 @default.
- W2155238293 hasRelatedWork W2019293658 @default.
- W2155238293 hasRelatedWork W2020163170 @default.
- W2155238293 hasRelatedWork W2021458573 @default.
- W2155238293 hasRelatedWork W2028354632 @default.
- W2155238293 hasRelatedWork W2044143372 @default.
- W2155238293 hasRelatedWork W2074554547 @default.
- W2155238293 hasRelatedWork W2145131902 @default.
- W2155238293 hasRelatedWork W2218526187 @default.
- W2155238293 hasRelatedWork W2583312838 @default.
- W2155238293 hasRelatedWork W2770102650 @default.
- W2155238293 hasRelatedWork W2887116812 @default.
- W2155238293 hasRelatedWork W2891702146 @default.
- W2155238293 hasRelatedWork W2908273233 @default.
- W2155238293 hasRelatedWork W2970533927 @default.
- W2155238293 hasRelatedWork W3188789931 @default.
- W2155238293 hasRelatedWork W73198019 @default.
- W2155238293 hasRelatedWork W753069543 @default.
- W2155238293 isParatext "false" @default.
- W2155238293 isRetracted "false" @default.
- W2155238293 magId "2155238293" @default.
- W2155238293 workType "article" @default.