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- W2155258338 abstract "Copper(II)-diacetyl-bis(N4-methylthiosemicarbazone), Cu–ATSM, labeled with a positron emitting isotope of copper (60Cu, 61Cu, 62Cu or 64Cu) has been shown, in vitro and in vivo, to be selective for hypoxic tissue. In silico studies have explored the mechanism of its hypoxia selectivity, and clinical studies with this agent have shown non-invasive imaging data that is predictive of a cancer patients' response to conventional therapy. This Perspective discusses the evolution of Cu–ATSM, how its selectivity can be improved upon, and where this metal–ligand platform could be taken in the future." @default.
- W2155258338 created "2016-06-24" @default.
- W2155258338 creator A5047368199 @default.
- W2155258338 creator A5068928963 @default.
- W2155258338 date "2007-01-01" @default.
- W2155258338 modified "2023-10-16" @default.
- W2155258338 title "Cu–ATSM: A radiopharmaceutical for the PET imaging of hypoxia" @default.
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- W2155258338 doi "https://doi.org/10.1039/b705989b" @default.
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