FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155258540> ?p ?o ?g. }

• W2155258540 endingPage "14264" @default.
• W2155258540 startingPage "14257" @default.
• W2155258540 abstract "Membrane ion channels activated by extracellular ATP (P2X receptors) are widely distributed in the nervous system. Their molecular architecture is fundamentally distinct from that of the nicotinic or glutamate receptor families. We have measured single-channel currents, spontaneous gating, and rectification of rat P2X2 receptor in which polar and charged residues of the second transmembrane domain (TM2) were systematically probed by mutagenesis. The results suggest that Asn 333 and Asp 349 lie respectively in external and internal vestibules. Substitutions at Asn 333 , Thr 336 , and Ser 340 were particularly likely to cause spontaneously active channels. At Thr 336 , Thr 339 , and Ser 340 , the introduction of positive charge (Arg, Lys, or His, or Cys followed by treatment with 2-aminoethyl methanethiosulphonate) greatly enhanced outward currents, suggesting that side-chains of these three residues are exposed in the permeation pathway of the open channel. These functional findings are interpreted in the context of the recently reported 3.1 Å crystal structure of the zebrafish P2X4.1 receptor in the closed state. They imply that the gate is formed by residues Asn 333 to Thr 339 and that channel opening involves a counter-clockwise rotation and separation of the TM2 helices." @default.
• W2155258540 created "2016-06-24" @default.
• W2155258540 creator A5037895771 @default.
• W2155258540 creator A5056934351 @default.
• W2155258540 creator A5083813747 @default.
• W2155258540 creator A5084712627 @default.
• W2155258540 date "2009-11-11" @default.
• W2155258540 modified "2023-10-17" @default.
• W2155258540 title "Polar Residues in the Second Transmembrane Domain of the Rat P2X2 Receptor That Affect Spontaneous Gating, Unitary Conductance, and Rectification" @default.
• W2155258540 cites W1524500351 @default.
• W2155258540 cites W1595178772 @default.
• W2155258540 cites W1622986665 @default.
• W2155258540 cites W1968920700 @default.
• W2155258540 cites W1969906502 @default.
• W2155258540 cites W2000163444 @default.
• W2155258540 cites W2006249554 @default.
• W2155258540 cites W2013025891 @default.
• W2155258540 cites W2020372966 @default.
• W2155258540 cites W2021184142 @default.
• W2155258540 cites W2027343672 @default.
• W2155258540 cites W2031434196 @default.
• W2155258540 cites W2038602542 @default.
• W2155258540 cites W2046207561 @default.
• W2155258540 cites W2056025481 @default.
• W2155258540 cites W2066784771 @default.
• W2155258540 cites W2071604766 @default.
• W2155258540 cites W2075237735 @default.
• W2155258540 cites W2081223551 @default.
• W2155258540 cites W2081556250 @default.
• W2155258540 cites W2099163813 @default.
• W2155258540 cites W2127366193 @default.
• W2155258540 cites W2128693861 @default.
• W2155258540 cites W2135562316 @default.
• W2155258540 cites W2136134177 @default.
• W2155258540 cites W2137132656 @default.
• W2155258540 cites W2148856791 @default.
• W2155258540 cites W2155452038 @default.
• W2155258540 cites W2156346381 @default.
• W2155258540 cites W2161761928 @default.
• W2155258540 cites W2170778319 @default.
• W2155258540 cites W2171763221 @default.
• W2155258540 cites W2186566705 @default.
• W2155258540 cites W4300873630 @default.
• W2155258540 doi "https://doi.org/10.1523/jneurosci.4403-09.2009" @default.
• W2155258540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2804292" @default.
• W2155258540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19906973" @default.
• W2155258540 hasPublicationYear "2009" @default.
• W2155258540 type Work @default.
• W2155258540 sameAs 2155258540 @default.
• W2155258540 citedByCount "48" @default.
• W2155258540 countsByYear W21552585402012 @default.
• W2155258540 countsByYear W21552585402013 @default.
• W2155258540 countsByYear W21552585402014 @default.
• W2155258540 countsByYear W21552585402015 @default.
• W2155258540 countsByYear W21552585402016 @default.
• W2155258540 countsByYear W21552585402017 @default.
• W2155258540 countsByYear W21552585402019 @default.
• W2155258540 countsByYear W21552585402020 @default.
• W2155258540 countsByYear W21552585402021 @default.
• W2155258540 crossrefType "journal-article" @default.
• W2155258540 hasAuthorship W2155258540A5037895771 @default.
• W2155258540 hasAuthorship W2155258540A5056934351 @default.
• W2155258540 hasAuthorship W2155258540A5083813747 @default.
• W2155258540 hasAuthorship W2155258540A5084712627 @default.
• W2155258540 hasBestOaLocation W21552585401 @default.
• W2155258540 hasConcept C118892022 @default.
• W2155258540 hasConcept C123419017 @default.
• W2155258540 hasConcept C12554922 @default.
• W2155258540 hasConcept C145822097 @default.
• W2155258540 hasConcept C151730666 @default.
• W2155258540 hasConcept C170493617 @default.
• W2155258540 hasConcept C185592680 @default.
• W2155258540 hasConcept C18903297 @default.
• W2155258540 hasConcept C194544171 @default.
• W2155258540 hasConcept C24530287 @default.
• W2155258540 hasConcept C2778530040 @default.
• W2155258540 hasConcept C2779343474 @default.
• W2155258540 hasConcept C2779570518 @default.
• W2155258540 hasConcept C2779965526 @default.
• W2155258540 hasConcept C50254741 @default.
• W2155258540 hasConcept C55493867 @default.
• W2155258540 hasConcept C71240020 @default.
• W2155258540 hasConcept C80161118 @default.
• W2155258540 hasConcept C86803240 @default.
• W2155258540 hasConceptScore W2155258540C118892022 @default.
• W2155258540 hasConceptScore W2155258540C123419017 @default.
• W2155258540 hasConceptScore W2155258540C12554922 @default.
• W2155258540 hasConceptScore W2155258540C145822097 @default.
• W2155258540 hasConceptScore W2155258540C151730666 @default.
• W2155258540 hasConceptScore W2155258540C170493617 @default.
• W2155258540 hasConceptScore W2155258540C185592680 @default.
• W2155258540 hasConceptScore W2155258540C18903297 @default.
• W2155258540 hasConceptScore W2155258540C194544171 @default.
• W2155258540 hasConceptScore W2155258540C24530287 @default.
• W2155258540 hasConceptScore W2155258540C2778530040 @default.
• W2155258540 hasConceptScore W2155258540C2779343474 @default.
• W2155258540 hasConceptScore W2155258540C2779570518 @default.
• W2155258540 hasConceptScore W2155258540C2779965526 @default.

• next