FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155258805> ?p ?o ?g. }

• W2155258805 endingPage "203" @default.
• W2155258805 startingPage "194" @default.
• W2155258805 abstract "This randomised, double-blind, parallel-group, mul-ticentre study investigated the effects of the dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist, tesaglitazar (0.5 and 1 mg), as add-on treatment in 568 patients with type 2 diabetes that was poorly controlled with sulphonylurea therapy titrated to the highest tolerated dose. There was a significant placebo-corrected reduction in glycosylated haemoglobin (HbA 1C ) from baseline to week 24 with tesaglitazar 0.5 mg and 1 mg (mean [95% confidence interval]: −0.93% [-1.09, −0.77] and −1.3% [-1.46, −1.14]; p<0.0001). Significant reductions were observed in insulin, fasting plasma glucose (FPG), triglyceride (all p<0.001) and non-high-density lipoprotein (HDL) cholesterol (p<0.001). Tesaglitazar increased levels of HDL-cholesterol (p<0.0001), adiponectin (p<0.0001) and leptin (p<0.001), but was associated with dose-dependent increases in serum creatinine and decreases in haemoglobin. This study showed improvements in glycaemic control and dyslipidaemia in patients with type 2 diabetes poorly controlled with existing sulphonylurea therapy. Although tesaglitazar has now been discontinued from clinical development, these results remain relevant to future research into PPAR agonists." @default.
• W2155258805 created "2016-06-24" @default.
• W2155258805 creator A5007149007 @default.
• W2155258805 creator A5039123807 @default.
• W2155258805 creator A5047195042 @default.
• W2155258805 date "2007-09-01" @default.
• W2155258805 modified "2023-10-16" @default.
• W2155258805 title "Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes" @default.
• W2155258805 cites W1968375269 @default.
• W2155258805 cites W1970022980 @default.
• W2155258805 cites W2003271348 @default.
• W2155258805 cites W2021624889 @default.
• W2155258805 cites W2031773477 @default.
• W2155258805 cites W2041113527 @default.
• W2155258805 cites W2047957470 @default.
• W2155258805 cites W2051882247 @default.
• W2155258805 cites W2054851194 @default.
• W2155258805 cites W2058216740 @default.
• W2155258805 cites W2060275151 @default.
• W2155258805 cites W2062255673 @default.
• W2155258805 cites W2068394230 @default.
• W2155258805 cites W2068529429 @default.
• W2155258805 cites W2074175997 @default.
• W2155258805 cites W2081276121 @default.
• W2155258805 cites W2085586940 @default.
• W2155258805 cites W2095763488 @default.
• W2155258805 cites W2099822840 @default.
• W2155258805 cites W2104224178 @default.
• W2155258805 cites W2107068945 @default.
• W2155258805 cites W2108550834 @default.
• W2155258805 cites W2108931588 @default.
• W2155258805 cites W2113936133 @default.
• W2155258805 cites W2114673579 @default.
• W2155258805 cites W2116404316 @default.
• W2155258805 cites W2127610524 @default.
• W2155258805 cites W2129428145 @default.
• W2155258805 cites W2137936645 @default.
• W2155258805 cites W2164576143 @default.
• W2155258805 cites W2198678228 @default.
• W2155258805 cites W2228488234 @default.
• W2155258805 cites W2264823571 @default.
• W2155258805 cites W4232807629 @default.
• W2155258805 cites W4238251256 @default.
• W2155258805 cites W4240449862 @default.
• W2155258805 doi "https://doi.org/10.3132/dvdr.2007.040" @default.
• W2155258805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17907109" @default.
• W2155258805 hasPublicationYear "2007" @default.
• W2155258805 type Work @default.
• W2155258805 sameAs 2155258805 @default.
• W2155258805 citedByCount "40" @default.
• W2155258805 countsByYear W21552588052012 @default.
• W2155258805 countsByYear W21552588052014 @default.
• W2155258805 countsByYear W21552588052015 @default.
• W2155258805 countsByYear W21552588052016 @default.
• W2155258805 countsByYear W21552588052017 @default.
• W2155258805 countsByYear W21552588052019 @default.
• W2155258805 countsByYear W21552588052020 @default.
• W2155258805 countsByYear W21552588052022 @default.
• W2155258805 countsByYear W21552588052023 @default.
• W2155258805 crossrefType "journal-article" @default.
• W2155258805 hasAuthorship W2155258805A5007149007 @default.
• W2155258805 hasAuthorship W2155258805A5039123807 @default.
• W2155258805 hasAuthorship W2155258805A5047195042 @default.
• W2155258805 hasBestOaLocation W21552588051 @default.
• W2155258805 hasConcept C126322002 @default.
• W2155258805 hasConcept C134018914 @default.
• W2155258805 hasConcept C142724271 @default.
• W2155258805 hasConcept C204787440 @default.
• W2155258805 hasConcept C27081682 @default.
• W2155258805 hasConcept C2776782570 @default.
• W2155258805 hasConcept C2777180221 @default.
• W2155258805 hasConcept C2777391703 @default.
• W2155258805 hasConcept C2778163477 @default.
• W2155258805 hasConcept C2778913445 @default.
• W2155258805 hasConcept C2780306776 @default.
• W2155258805 hasConcept C555293320 @default.
• W2155258805 hasConcept C71924100 @default.
• W2155258805 hasConceptScore W2155258805C126322002 @default.
• W2155258805 hasConceptScore W2155258805C134018914 @default.
• W2155258805 hasConceptScore W2155258805C142724271 @default.
• W2155258805 hasConceptScore W2155258805C204787440 @default.
• W2155258805 hasConceptScore W2155258805C27081682 @default.
• W2155258805 hasConceptScore W2155258805C2776782570 @default.
• W2155258805 hasConceptScore W2155258805C2777180221 @default.
• W2155258805 hasConceptScore W2155258805C2777391703 @default.
• W2155258805 hasConceptScore W2155258805C2778163477 @default.
• W2155258805 hasConceptScore W2155258805C2778913445 @default.
• W2155258805 hasConceptScore W2155258805C2780306776 @default.
• W2155258805 hasConceptScore W2155258805C555293320 @default.
• W2155258805 hasConceptScore W2155258805C71924100 @default.
• W2155258805 hasIssue "3" @default.
• W2155258805 hasLocation W21552588051 @default.
• W2155258805 hasLocation W21552588052 @default.
• W2155258805 hasOpenAccess W2155258805 @default.
• W2155258805 hasPrimaryLocation W21552588051 @default.
• W2155258805 hasRelatedWork W1982589044 @default.
• W2155258805 hasRelatedWork W1988439151 @default.
• W2155258805 hasRelatedWork W2000536767 @default.

• next