FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155269413> ?p ?o ?g. }

• W2155269413 endingPage "618" @default.
• W2155269413 startingPage "616" @default.
• W2155269413 abstract "Osteosarcoma is the most common primary malignant tumor of bone. Except for the improvement in five-year survival achieved by the adoption of neoadjuvant chemotherapy strategy, there are nearly no improvement for the treatment of osteosarcoma in the past 30 years, especially for the patients with metastatic disease. Immunotherapy has been successfully applied in some tumors. The survival of osteosarcoma patients enrolled in several clinical immunotherapy trials did be improved in the past. Immunotherapy might further improve the therapy result of osteosarcoma patients besides neoadjuvant chemotherapy. But there still are many problems needed to be solved before clinically successful application. Immune escape is one of the main obstacles hindering the immunotherapy for osteosarcoma. No effective tumor antigens, or in other words, attenuated immunogenicity is one of the main mechanisms of immune escape. So the key point of immunotherapy for osteosarcoma is to find out an effective target through which the immune system can recognize this tumor and attack it. Genetic modification of immune system may circumvent this problem by enhancing the capacity of immune system. Chimeric antigen receptor (CAR), an artificial receptor generated by genetic manipulation, is a promising technique. The CAR technique can circumvent the restriction of major histocompatibility in antigen recognition for T cells, and is more effective than the corresponding antibody to get rid of tumor cells. But short persistence of the CAR expressing T cells in vivo is the main problem of CAR technique in current research. This problem is believed to have some relation to the immunogenicity of the artificial receptor because the antigen recognizing portion of receptor is derived from monoclonal antibody. So we believe that the elimination of the immunogenicity of CAR might prolong the persistence of CAR expressing T cells in vivo and put forward a hypothesis that the antigen binding portion of CAR could be derived from the antibody against osteosarcoma antigen from the same patient with osteosarcoma by methods such as antibody phage display, BRASIL technique. We believe that CAR expressing T cells constructed by this strategy would persist longer and are more effective to eradicate osteosarcoma cells. In addition, this treatment strategy is an individualized treatment because an effective target specific to the CAR could be found. Therefore the immune escape of osteosarcoma would be surmounted and the survival of patients would be improved." @default.
• W2155269413 created "2016-06-24" @default.
• W2155269413 creator A5027212997 @default.
• W2155269413 creator A5087185685 @default.
• W2155269413 date "2012-05-01" @default.
• W2155269413 modified "2023-09-23" @default.
• W2155269413 title "Auto T cells expressing chimeric antigen receptor derived from auto antibody might be a new treatment for osteosarcoma" @default.
• W2155269413 cites W1967159277 @default.
• W2155269413 cites W1978207526 @default.
• W2155269413 cites W2004919491 @default.
• W2155269413 cites W2007576727 @default.
• W2155269413 cites W2019855795 @default.
• W2155269413 cites W2028460943 @default.
• W2155269413 cites W2046056027 @default.
• W2155269413 cites W2047860874 @default.
• W2155269413 cites W2051549641 @default.
• W2155269413 cites W2070660250 @default.
• W2155269413 cites W2087857484 @default.
• W2155269413 cites W2103405666 @default.
• W2155269413 cites W2104341033 @default.
• W2155269413 cites W2117614828 @default.
• W2155269413 cites W2125028197 @default.
• W2155269413 cites W2159222883 @default.
• W2155269413 cites W4301796917 @default.
• W2155269413 doi "https://doi.org/10.1016/j.mehy.2012.01.038" @default.
• W2155269413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22330890" @default.
• W2155269413 hasPublicationYear "2012" @default.
• W2155269413 type Work @default.
• W2155269413 sameAs 2155269413 @default.
• W2155269413 citedByCount "5" @default.
• W2155269413 countsByYear W21552694132015 @default.
• W2155269413 countsByYear W21552694132016 @default.
• W2155269413 countsByYear W21552694132020 @default.
• W2155269413 countsByYear W21552694132021 @default.
• W2155269413 crossrefType "journal-article" @default.
• W2155269413 hasAuthorship W2155269413A5027212997 @default.
• W2155269413 hasAuthorship W2155269413A5087185685 @default.
• W2155269413 hasConcept C147483822 @default.
• W2155269413 hasConcept C203014093 @default.
• W2155269413 hasConcept C2777701055 @default.
• W2155269413 hasConcept C2777760704 @default.
• W2155269413 hasConcept C2780868878 @default.
• W2155269413 hasConcept C3875195 @default.
• W2155269413 hasConcept C502942594 @default.
• W2155269413 hasConcept C71924100 @default.
• W2155269413 hasConcept C8891405 @default.
• W2155269413 hasConceptScore W2155269413C147483822 @default.
• W2155269413 hasConceptScore W2155269413C203014093 @default.
• W2155269413 hasConceptScore W2155269413C2777701055 @default.
• W2155269413 hasConceptScore W2155269413C2777760704 @default.
• W2155269413 hasConceptScore W2155269413C2780868878 @default.
• W2155269413 hasConceptScore W2155269413C3875195 @default.
• W2155269413 hasConceptScore W2155269413C502942594 @default.
• W2155269413 hasConceptScore W2155269413C71924100 @default.
• W2155269413 hasConceptScore W2155269413C8891405 @default.
• W2155269413 hasIssue "5" @default.
• W2155269413 hasLocation W21552694131 @default.
• W2155269413 hasLocation W21552694132 @default.
• W2155269413 hasOpenAccess W2155269413 @default.
• W2155269413 hasPrimaryLocation W21552694131 @default.
• W2155269413 hasRelatedWork W1519040467 @default.
• W2155269413 hasRelatedWork W1974103061 @default.
• W2155269413 hasRelatedWork W1995017465 @default.
• W2155269413 hasRelatedWork W2009090497 @default.
• W2155269413 hasRelatedWork W2155269413 @default.
• W2155269413 hasRelatedWork W2220102944 @default.
• W2155269413 hasRelatedWork W2327043232 @default.
• W2155269413 hasRelatedWork W2411712784 @default.
• W2155269413 hasRelatedWork W2888060141 @default.
• W2155269413 hasRelatedWork W3022872369 @default.
• W2155269413 hasVolume "78" @default.
• W2155269413 isParatext "false" @default.
• W2155269413 isRetracted "false" @default.
• W2155269413 magId "2155269413" @default.
• W2155269413 workType "article" @default.