Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155276021> ?p ?o ?g. }
- W2155276021 endingPage "711" @default.
- W2155276021 startingPage "699" @default.
- W2155276021 abstract "Hematopoietic stem cells (HSCs) are thought to arise in the aorta-gonad-mesonephros (AGM) region of embryo proper, although HSC activity can be detected in yolk sac (YS) and paraaortic splanchnopleura (P-Sp) when transplanted in newborn mice. We examined the role of Notch signaling in embryonic hematopoiesis. The activity of colony-forming cells in the YS from Notch1(-/-) embryos was comparable to that of wild-type embryos. However, in vitro and in vivo definitive hematopoietic activities from YS and P-Sp were severely impaired in Notch1(-/-) embryos. The population representing hemogenic endothelial cells, however, did not decrease. In contrast, Notch2(-/-) embryos showed no hematopoietic deficiency. These data indicate that Notch1, but not Notch2, is essential for generating hematopoietic stem cells from endothelial cells." @default.
- W2155276021 created "2016-06-24" @default.
- W2155276021 creator A5011755925 @default.
- W2155276021 creator A5015073290 @default.
- W2155276021 creator A5024940598 @default.
- W2155276021 creator A5042588749 @default.
- W2155276021 creator A5059478700 @default.
- W2155276021 creator A5062792348 @default.
- W2155276021 creator A5067046418 @default.
- W2155276021 creator A5067804516 @default.
- W2155276021 creator A5074294360 @default.
- W2155276021 creator A5078739904 @default.
- W2155276021 creator A5080083757 @default.
- W2155276021 creator A5081126904 @default.
- W2155276021 creator A5088372604 @default.
- W2155276021 date "2003-05-01" @default.
- W2155276021 modified "2023-10-18" @default.
- W2155276021 title "Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells" @default.
- W2155276021 cites W115221593 @default.
- W2155276021 cites W1553072335 @default.
- W2155276021 cites W1555225591 @default.
- W2155276021 cites W1559931184 @default.
- W2155276021 cites W1591850953 @default.
- W2155276021 cites W1674015201 @default.
- W2155276021 cites W1763915099 @default.
- W2155276021 cites W1816761971 @default.
- W2155276021 cites W1879493681 @default.
- W2155276021 cites W1937332911 @default.
- W2155276021 cites W1980669457 @default.
- W2155276021 cites W1984270581 @default.
- W2155276021 cites W1999047431 @default.
- W2155276021 cites W2000156766 @default.
- W2155276021 cites W2005760229 @default.
- W2155276021 cites W2007821776 @default.
- W2155276021 cites W2009000506 @default.
- W2155276021 cites W2011745548 @default.
- W2155276021 cites W2012866178 @default.
- W2155276021 cites W2015739079 @default.
- W2155276021 cites W2018527149 @default.
- W2155276021 cites W2019216667 @default.
- W2155276021 cites W2021516648 @default.
- W2155276021 cites W2028050458 @default.
- W2155276021 cites W2028196271 @default.
- W2155276021 cites W2031945557 @default.
- W2155276021 cites W2032528704 @default.
- W2155276021 cites W2032951893 @default.
- W2155276021 cites W2037147735 @default.
- W2155276021 cites W2042982622 @default.
- W2155276021 cites W2044923556 @default.
- W2155276021 cites W2051433490 @default.
- W2155276021 cites W2055568103 @default.
- W2155276021 cites W2056384897 @default.
- W2155276021 cites W2067131315 @default.
- W2155276021 cites W2067250364 @default.
- W2155276021 cites W2070678884 @default.
- W2155276021 cites W2078597493 @default.
- W2155276021 cites W2081026902 @default.
- W2155276021 cites W2082133442 @default.
- W2155276021 cites W2083035091 @default.
- W2155276021 cites W2083904945 @default.
- W2155276021 cites W2085030176 @default.
- W2155276021 cites W2085033687 @default.
- W2155276021 cites W2100699398 @default.
- W2155276021 cites W2107141327 @default.
- W2155276021 cites W2118623951 @default.
- W2155276021 cites W2118903548 @default.
- W2155276021 cites W2120281059 @default.
- W2155276021 cites W2123478725 @default.
- W2155276021 cites W2127432537 @default.
- W2155276021 cites W2130422603 @default.
- W2155276021 cites W2131301194 @default.
- W2155276021 cites W2140136203 @default.
- W2155276021 cites W2140553945 @default.
- W2155276021 cites W2145150521 @default.
- W2155276021 cites W2146660065 @default.
- W2155276021 cites W2150409084 @default.
- W2155276021 cites W2154861644 @default.
- W2155276021 cites W2157187112 @default.
- W2155276021 cites W2166463603 @default.
- W2155276021 cites W2171623512 @default.
- W2155276021 cites W2260668538 @default.
- W2155276021 cites W2404234352 @default.
- W2155276021 cites W4229894669 @default.
- W2155276021 cites W4234143216 @default.
- W2155276021 cites W4246509598 @default.
- W2155276021 cites W8143991 @default.
- W2155276021 doi "https://doi.org/10.1016/s1074-7613(03)00117-1" @default.
- W2155276021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12753746" @default.
- W2155276021 hasPublicationYear "2003" @default.
- W2155276021 type Work @default.
- W2155276021 sameAs 2155276021 @default.
- W2155276021 citedByCount "443" @default.
- W2155276021 countsByYear W21552760212012 @default.
- W2155276021 countsByYear W21552760212013 @default.
- W2155276021 countsByYear W21552760212014 @default.
- W2155276021 countsByYear W21552760212015 @default.
- W2155276021 countsByYear W21552760212016 @default.
- W2155276021 countsByYear W21552760212017 @default.