FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155276106> ?p ?o ?g. }

• W2155276106 endingPage "93" @default.
• W2155276106 startingPage "82" @default.
• W2155276106 abstract "Objective: Obsessive-compulsive disorder (OCD) and Tourette’s syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette’s syndrome and OCD. Method: The authors conducted a GWAS in 2,723 cases (1,310 with OCD, 834 with Tourette’s syndrome, 579 with OCD plus Tourette’s syndrome/chronic tics), 5,667 ancestry-matched controls, and 290 OCD parent-child trios. GWAS summary statistics were examined for enrichment of functional variants associated with gene expression levels in brain regions. Polygenic score analyses were conducted to investigate the genetic architecture within and across the two disorders. Results: Although no individual single-nucleotide polymorphisms (SNPs) achieved genome-wide significance, the GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders. Polygenic score analyses identified a significant polygenic component for OCD (p=2×10−4), predicting 3.2% of the phenotypic variance in an independent data set. In contrast, Tourette’s syndrome had a smaller, nonsignificant polygenic component, predicting only 0.6% of the phenotypic variance (p=0.06). No significant polygenic signal was detected across the two disorders, although the sample is likely underpowered to detect a modest shared signal. Furthermore, the OCD polygenic signal was significantly attenuated when cases with both OCD and co-occurring Tourette’s syndrome/chronic tics were included in the analysis (p=0.01). Conclusions: Previous work has shown that Tourette’s syndrome and OCD have some degree of shared genetic variation. However, the data from this study suggest that there are also distinct components to the genetic architectures of these two disorders. Furthermore, OCD with co-occurring Tourette’s syndrome/chronic tics may have different underlying genetic susceptibility compared with OCD alone." @default.
• W2155276106 created "2016-06-24" @default.
• W2155276106 creator A5001094886 @default.
• W2155276106 creator A5002090056 @default.
• W2155276106 creator A5002321122 @default.
• W2155276106 creator A5002628021 @default.
• W2155276106 creator A5004274374 @default.
• W2155276106 creator A5004754581 @default.
• W2155276106 creator A5005424070 @default.
• W2155276106 creator A5005847583 @default.
• W2155276106 creator A5007250735 @default.
• W2155276106 creator A5007768066 @default.
• W2155276106 creator A5007967936 @default.
• W2155276106 creator A5009372831 @default.
• W2155276106 creator A5009905748 @default.
• W2155276106 creator A5010330140 @default.
• W2155276106 creator A5010458603 @default.
• W2155276106 creator A5010692059 @default.
• W2155276106 creator A5010857043 @default.
• W2155276106 creator A5011013793 @default.
• W2155276106 creator A5012656680 @default.
• W2155276106 creator A5013118703 @default.
• W2155276106 creator A5013816247 @default.
• W2155276106 creator A5013870163 @default.
• W2155276106 creator A5015235673 @default.
• W2155276106 creator A5015892598 @default.
• W2155276106 creator A5015972894 @default.
• W2155276106 creator A5015988796 @default.
• W2155276106 creator A5016155997 @default.
• W2155276106 creator A5017363058 @default.
• W2155276106 creator A5017405820 @default.
• W2155276106 creator A5018555161 @default.
• W2155276106 creator A5018863416 @default.
• W2155276106 creator A5019064977 @default.
• W2155276106 creator A5019654755 @default.
• W2155276106 creator A5020448299 @default.
• W2155276106 creator A5020514779 @default.
• W2155276106 creator A5020941152 @default.
• W2155276106 creator A5021167152 @default.
• W2155276106 creator A5022196539 @default.
• W2155276106 creator A5022855713 @default.
• W2155276106 creator A5023240794 @default.
• W2155276106 creator A5023377249 @default.
• W2155276106 creator A5023507812 @default.
• W2155276106 creator A5024618024 @default.
• W2155276106 creator A5025278422 @default.
• W2155276106 creator A5029578725 @default.
• W2155276106 creator A5029879049 @default.
• W2155276106 creator A5031267110 @default.
• W2155276106 creator A5031288381 @default.
• W2155276106 creator A5031441220 @default.
• W2155276106 creator A5031741821 @default.
• W2155276106 creator A5032133413 @default.
• W2155276106 creator A5032139668 @default.
• W2155276106 creator A5032615209 @default.
• W2155276106 creator A5032997650 @default.
• W2155276106 creator A5033301831 @default.
• W2155276106 creator A5033767498 @default.
• W2155276106 creator A5033788029 @default.
• W2155276106 creator A5035535823 @default.
• W2155276106 creator A5036065803 @default.
• W2155276106 creator A5036285184 @default.
• W2155276106 creator A5036388273 @default.
• W2155276106 creator A5037335965 @default.
• W2155276106 creator A5037469384 @default.
• W2155276106 creator A5037586820 @default.
• W2155276106 creator A5037625817 @default.
• W2155276106 creator A5038038028 @default.
• W2155276106 creator A5038120098 @default.
• W2155276106 creator A5038137660 @default.
• W2155276106 creator A5039176320 @default.
• W2155276106 creator A5039838663 @default.
• W2155276106 creator A5041320761 @default.
• W2155276106 creator A5042651482 @default.
• W2155276106 creator A5043863759 @default.
• W2155276106 creator A5044457835 @default.
• W2155276106 creator A5045051798 @default.
• W2155276106 creator A5045262408 @default.
• W2155276106 creator A5045721609 @default.
• W2155276106 creator A5045915230 @default.
• W2155276106 creator A5046105483 @default.
• W2155276106 creator A5047098889 @default.
• W2155276106 creator A5050309987 @default.
• W2155276106 creator A5050853005 @default.
• W2155276106 creator A5051058343 @default.
• W2155276106 creator A5051460895 @default.
• W2155276106 creator A5051608927 @default.
• W2155276106 creator A5051933272 @default.
• W2155276106 creator A5052016436 @default.
• W2155276106 creator A5052083736 @default.
• W2155276106 creator A5052290354 @default.
• W2155276106 creator A5053185744 @default.
• W2155276106 creator A5053558359 @default.
• W2155276106 creator A5053842284 @default.
• W2155276106 creator A5054861340 @default.
• W2155276106 creator A5055092029 @default.
• W2155276106 creator A5055147850 @default.
• W2155276106 creator A5055722007 @default.

• next