Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155276590> ?p ?o ?g. }
- W2155276590 abstract "Heart transplantation has become the treatment of choice for patients with end-stage heart diseases. Originally, strict recipient and donor selection criteria were developed to minimize morbidity and mortality after heart transplantation. However, the increasing demand for heart transplantation has led to the liberalization of the traditional recipient selection criteria. There has been a gradual increase of recipient age. Patients at poor health status, e.g. pretransplant diagnosis of end-stage valvular heart disease and older recipients, are more likely to have a higher morbidity and mortality due to co-existing medical problems. The increased gap between the demand and supply of donor hearts results in significant prolonged waiting time and an increased mortality of recipients on the waiting list. To increase donor supply, acceptance criteria of donor hearts have been expanded to include the sub-optimal or marginal donor hearts. Nevertheless, the impact of these trends on the outcome of heart transplantation, in particular on long term, remains uncertain. Heart transplantation should be reserved for those patients most likely to benefit in terms of survival. To enable predicting the outcome for individual patient based on recipient and donor characteristics, and their match, a prediction model may play a crucial role in selection of a donor heart to a specific recipient. The focus of this thesis is on the impact of various recipient and donor baseline characteristics on the outcome after adult heart transplantation. This thesis also includes several models that have been developed and validated to predict mortality risk after adult heart transplantation. We demonstrated that despite changing in baseline risk profiles at different transplant periods, the survival of adult heart transplantation remains stable and encouraging. Moreover, we showed that prognosis after heart transplantation in patients with end-stage valvular disease is similar to patients with other indications, whereas a longer waiting time to heart transplantation significantly improved survival. Our results also demonstrated that the outcome of heart transplantation in older recipients is less favorable than in younger patients. Therefore, the decision to offer heart transplantation to recipients older than 55 years should be considered cautiously. Furthermore, we found that heart transplantation from donors with sodium level > 155 mmol/L and using donor hearts that have been subject to cardiopulmonary resuscitation do not adversely affect the outcome of heart transplantation. Accepting such donor hearts will add to the enlargement of the donor pool, and guidelines should be adjusted accordingly. Finally, we have shown that the 30-day, 1- and 5-year mortality risk after adult heart transplantation could be predicted with accuracy based on pretransplant clinical characteristics of recipients and donors as well as perioperative data. The prediction models which were converted to easy use nomograms provide easily applicable instruments for prediction of mortality risk after adult heart transplantation. Their use in clinical practice can support decisions on allocation of limited number of donor hearts to patients waiting for heart transplantation in an optimal manner." @default.
- W2155276590 created "2016-06-24" @default.
- W2155276590 creator A5058513293 @default.
- W2155276590 date "2008-07-10" @default.
- W2155276590 modified "2023-09-27" @default.
- W2155276590 title "Predicting Outcome of Heart Transplantation" @default.
- W2155276590 cites W113011335 @default.
- W2155276590 cites W125985407 @default.
- W2155276590 cites W140860561 @default.
- W2155276590 cites W1491190219 @default.
- W2155276590 cites W1512182366 @default.
- W2155276590 cites W1593482304 @default.
- W2155276590 cites W1696783437 @default.
- W2155276590 cites W1964326728 @default.
- W2155276590 cites W1964842559 @default.
- W2155276590 cites W1969039092 @default.
- W2155276590 cites W1970915913 @default.
- W2155276590 cites W1971732268 @default.
- W2155276590 cites W1972047764 @default.
- W2155276590 cites W1972188411 @default.
- W2155276590 cites W1972355376 @default.
- W2155276590 cites W1976897100 @default.
- W2155276590 cites W1977000117 @default.
- W2155276590 cites W1981552711 @default.
- W2155276590 cites W1981619393 @default.
- W2155276590 cites W1982093635 @default.
- W2155276590 cites W1983564950 @default.
- W2155276590 cites W1983607743 @default.
- W2155276590 cites W1985353424 @default.
- W2155276590 cites W1989111416 @default.
- W2155276590 cites W1992057451 @default.
- W2155276590 cites W1993442513 @default.
- W2155276590 cites W1994434747 @default.
- W2155276590 cites W1995945562 @default.
- W2155276590 cites W1996244095 @default.
- W2155276590 cites W1996845108 @default.
- W2155276590 cites W2001485903 @default.
- W2155276590 cites W2002989725 @default.
- W2155276590 cites W2004526648 @default.
- W2155276590 cites W2004881651 @default.
- W2155276590 cites W2006590103 @default.
- W2155276590 cites W2007826154 @default.
- W2155276590 cites W2009876051 @default.
- W2155276590 cites W2010629053 @default.
- W2155276590 cites W2010863788 @default.
- W2155276590 cites W2011093022 @default.
- W2155276590 cites W2011595811 @default.
- W2155276590 cites W2012531834 @default.
- W2155276590 cites W2012625368 @default.
- W2155276590 cites W2015226575 @default.
- W2155276590 cites W2015326385 @default.
- W2155276590 cites W2016267284 @default.
- W2155276590 cites W2018806167 @default.
- W2155276590 cites W2019300001 @default.
- W2155276590 cites W2019991630 @default.
- W2155276590 cites W2026351056 @default.
- W2155276590 cites W2028132419 @default.
- W2155276590 cites W2029466071 @default.
- W2155276590 cites W2033691258 @default.
- W2155276590 cites W2034114625 @default.
- W2155276590 cites W2035612225 @default.
- W2155276590 cites W2037530981 @default.
- W2155276590 cites W2037668591 @default.
- W2155276590 cites W2038341671 @default.
- W2155276590 cites W2040426476 @default.
- W2155276590 cites W2041382247 @default.
- W2155276590 cites W2042154642 @default.
- W2155276590 cites W2043777932 @default.
- W2155276590 cites W2044716621 @default.
- W2155276590 cites W2045589608 @default.
- W2155276590 cites W2048602059 @default.
- W2155276590 cites W2049075009 @default.
- W2155276590 cites W2051140524 @default.
- W2155276590 cites W2052775539 @default.
- W2155276590 cites W2052892087 @default.
- W2155276590 cites W2054603937 @default.
- W2155276590 cites W2055781011 @default.
- W2155276590 cites W2056254709 @default.
- W2155276590 cites W2056573972 @default.
- W2155276590 cites W2060038284 @default.
- W2155276590 cites W2062165989 @default.
- W2155276590 cites W2062933172 @default.
- W2155276590 cites W2063662218 @default.
- W2155276590 cites W2065521646 @default.
- W2155276590 cites W2067481834 @default.
- W2155276590 cites W2069778995 @default.
- W2155276590 cites W2080044188 @default.
- W2155276590 cites W2080185366 @default.
- W2155276590 cites W2081122298 @default.
- W2155276590 cites W2081310937 @default.
- W2155276590 cites W2084394145 @default.
- W2155276590 cites W2088456143 @default.
- W2155276590 cites W2091127531 @default.
- W2155276590 cites W2096447461 @default.
- W2155276590 cites W2098016433 @default.
- W2155276590 cites W2099046884 @default.
- W2155276590 cites W2101385403 @default.
- W2155276590 cites W2103104923 @default.
- W2155276590 cites W2103700799 @default.
- W2155276590 cites W2106192035 @default.