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- W2155280333 abstract "Green tea (Camellia sinensis L.) and Rooibos (Aspalathus linearis Dahlg.) inhibit angiotensin-converting enzyme (ACE) in vitro and in vivo. The ACE inhibitor enalaprilat has been described previously as a competitive inhibitor and sometimes as a non-competitive inhibitor. The aim of this study was to investigate the pharmacological mechanism of ACE inhibition of green tea and Rooibos by enzyme kinetics, and to compare this with enalaprilat. A Michaelis–Menten kinetics and Lineweaver–Burk graph showed mean values of Vmax = 3.73 µ m and Km = 0.71 µ m for green tea, of Vmax = 6.76 µ m and Km = 0.78 µ m for Rooibos, of Vmax = 12.54 µ m and Km = 2.77 µ m for enalaprilat, and of Vmax = 51.33 µ m and Km = 9.22 µ m for the PBS control. Incubating serum with green tea or Rooibos saturated with zinc chloride did not change the inhibitory effect. Enalaprilat preincubated with zinc chloride showed a decrease in the inhibitory effect. In conclusion, green tea, Rooibos and enalaprilat seem to inhibit ACE activity using a mixed inhibitor mechanism. Copyright © 2011 John Wiley & Sons, Ltd." @default.
- W2155280333 created "2016-06-24" @default.
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- W2155280333 date "2011-09-08" @default.
- W2155280333 modified "2023-09-27" @default.
- W2155280333 title "The Pharmacological Mechanism of Angiotensin-converting Enzyme Inhibition by Green Tea, Rooibos and Enalaprilat - A Study on Enzyme Kinetics" @default.
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- W2155280333 doi "https://doi.org/10.1002/ptr.3588" @default.
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