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- W2155280938 abstract "Cancer stem-like cells were isolated from several human tumor cell lines by limiting dilution assays and holoclone morphology, followed by assessment of self-renewal capacity, tumor growth, vascularity, and blood perfusion. H460 holoclone-derived tumors grew slower than parental H460 tumors, but displayed significantly increased microvessel density and tumor blood perfusion. Microarray analysis identified 177 differentially regulated genes in the holoclone-derived tumors, of which 47 were associated with angiogenesis. The dysregulated genes include several small leucine-rich proteoglycans that may modulate angiogenesis and serve as novel therapeutic targets for inhibiting cancer stem cell-driven angiogenesis." @default.
- W2155280938 created "2016-06-24" @default.
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- W2155280938 date "2014-04-01" @default.
- W2155280938 modified "2023-10-16" @default.
- W2155280938 title "H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity" @default.
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- W2155280938 doi "https://doi.org/10.1016/j.canlet.2013.12.012" @default.
- W2155280938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3947657" @default.
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