Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155286963> ?p ?o ?g. }
- W2155286963 endingPage "6" @default.
- W2155286963 startingPage "1" @default.
- W2155286963 abstract "Abstract Objective This study aimed to investigate the role of progressive periodontal disease in inducing bisphosphonate‐related osteonecrosis of the jaws ( BRONJ ) using an ovariectomized ( OVX ) rat model mimicking human intracortical remodeling process. Materials and methods Thirty 12‐week‐old Spraque–Dawly ( SD ) female rats were randomly assigned into two groups. All rats underwent bilateral ovariectomy. Six weeks after surgery, zoledronic acid ( ZA ) or vehicle control was administered intraperitoneally for 12 weeks. On the same day of injection, a cotton ligature was placed subgingivally around the first left lower molar to induce periodontitis. All animals were sacrificed 12 weeks after injection. The entire mandibles were harvested for micro‐computed tomography (micro‐ CT ) and histological examinations. Results Micro‐ CT examination showed that ligature placement caused significant alveolar bone loss both in ZA (0.63 ± 0.13 vs. 0.38 ± 0.06 mm, P < 0.001) and in control (0.88 ± 0.19 vs. 0.40 ± 0.06 mm, P < 0.001) groups. Whereas in the ZA group, bone loss was attenuated compared with the control group ( P < 0.01); the bone mineral density in the ZA group (1.00 ± 0.02 g/cm 3 ) was significantly higher than that in vehicle control group (0.96 ± 0.03 g/cm 3 , P < 0.001). Histological examination found necrotic bone tissue with extensive, empty lacunae in two of 15 rats in ZA group, but in none of the control group. Conclusion Bisphosphonates inhibit alveolar bone resorption in progressive periodontal disease, which might benefit the management of periodontitis, but increase the risk of developing BRONJ ." @default.
- W2155286963 created "2016-06-24" @default.
- W2155286963 creator A5014464593 @default.
- W2155286963 creator A5039373722 @default.
- W2155286963 creator A5066745547 @default.
- W2155286963 creator A5076379245 @default.
- W2155286963 creator A5079442304 @default.
- W2155286963 creator A5086679643 @default.
- W2155286963 date "2014-11-05" @default.
- W2155286963 modified "2023-10-16" @default.
- W2155286963 title "Role of periodontal disease in bisphosphonate‐related osteonecrosis of the jaws in ovariectomized rats" @default.
- W2155286963 cites W1893152447 @default.
- W2155286963 cites W1983816613 @default.
- W2155286963 cites W2016215015 @default.
- W2155286963 cites W2018330838 @default.
- W2155286963 cites W2019076654 @default.
- W2155286963 cites W2023163938 @default.
- W2155286963 cites W2027093084 @default.
- W2155286963 cites W2049647212 @default.
- W2155286963 cites W2076370157 @default.
- W2155286963 cites W2079435554 @default.
- W2155286963 cites W2087378917 @default.
- W2155286963 cites W2089233716 @default.
- W2155286963 cites W2094483196 @default.
- W2155286963 cites W2101213724 @default.
- W2155286963 cites W2107208293 @default.
- W2155286963 cites W2117196299 @default.
- W2155286963 cites W2122972229 @default.
- W2155286963 cites W2134304734 @default.
- W2155286963 cites W2143254775 @default.
- W2155286963 cites W2150904792 @default.
- W2155286963 cites W2164666581 @default.
- W2155286963 cites W2165326697 @default.
- W2155286963 cites W2166212566 @default.
- W2155286963 cites W2169512870 @default.
- W2155286963 cites W2169780026 @default.
- W2155286963 cites W2171960239 @default.
- W2155286963 doi "https://doi.org/10.1111/clr.12502" @default.
- W2155286963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25371026" @default.
- W2155286963 hasPublicationYear "2014" @default.
- W2155286963 type Work @default.
- W2155286963 sameAs 2155286963 @default.
- W2155286963 citedByCount "31" @default.
- W2155286963 countsByYear W21552869632015 @default.
- W2155286963 countsByYear W21552869632016 @default.
- W2155286963 countsByYear W21552869632017 @default.
- W2155286963 countsByYear W21552869632018 @default.
- W2155286963 countsByYear W21552869632019 @default.
- W2155286963 countsByYear W21552869632020 @default.
- W2155286963 countsByYear W21552869632021 @default.
- W2155286963 countsByYear W21552869632022 @default.
- W2155286963 countsByYear W21552869632023 @default.
- W2155286963 crossrefType "journal-article" @default.
- W2155286963 hasAuthorship W2155286963A5014464593 @default.
- W2155286963 hasAuthorship W2155286963A5039373722 @default.
- W2155286963 hasAuthorship W2155286963A5066745547 @default.
- W2155286963 hasAuthorship W2155286963A5076379245 @default.
- W2155286963 hasAuthorship W2155286963A5079442304 @default.
- W2155286963 hasAuthorship W2155286963A5086679643 @default.
- W2155286963 hasConcept C126322002 @default.
- W2155286963 hasConcept C142724271 @default.
- W2155286963 hasConcept C146562846 @default.
- W2155286963 hasConcept C151279780 @default.
- W2155286963 hasConcept C170033053 @default.
- W2155286963 hasConcept C199343813 @default.
- W2155286963 hasConcept C202271784 @default.
- W2155286963 hasConcept C204787440 @default.
- W2155286963 hasConcept C2775961468 @default.
- W2155286963 hasConcept C2776326535 @default.
- W2155286963 hasConcept C2776541429 @default.
- W2155286963 hasConcept C2777164284 @default.
- W2155286963 hasConcept C2777251235 @default.
- W2155286963 hasConcept C2777998629 @default.
- W2155286963 hasConcept C2780385504 @default.
- W2155286963 hasConcept C2992452445 @default.
- W2155286963 hasConcept C673006 @default.
- W2155286963 hasConcept C71924100 @default.
- W2155286963 hasConcept C8264082 @default.
- W2155286963 hasConceptScore W2155286963C126322002 @default.
- W2155286963 hasConceptScore W2155286963C142724271 @default.
- W2155286963 hasConceptScore W2155286963C146562846 @default.
- W2155286963 hasConceptScore W2155286963C151279780 @default.
- W2155286963 hasConceptScore W2155286963C170033053 @default.
- W2155286963 hasConceptScore W2155286963C199343813 @default.
- W2155286963 hasConceptScore W2155286963C202271784 @default.
- W2155286963 hasConceptScore W2155286963C204787440 @default.
- W2155286963 hasConceptScore W2155286963C2775961468 @default.
- W2155286963 hasConceptScore W2155286963C2776326535 @default.
- W2155286963 hasConceptScore W2155286963C2776541429 @default.
- W2155286963 hasConceptScore W2155286963C2777164284 @default.
- W2155286963 hasConceptScore W2155286963C2777251235 @default.
- W2155286963 hasConceptScore W2155286963C2777998629 @default.
- W2155286963 hasConceptScore W2155286963C2780385504 @default.
- W2155286963 hasConceptScore W2155286963C2992452445 @default.
- W2155286963 hasConceptScore W2155286963C673006 @default.
- W2155286963 hasConceptScore W2155286963C71924100 @default.
- W2155286963 hasConceptScore W2155286963C8264082 @default.
- W2155286963 hasIssue "1" @default.