FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155291572> ?p ?o ?g. }

• W2155291572 endingPage "H1658" @default.
• W2155291572 startingPage "H1653" @default.
• W2155291572 abstract "Embryonic stem cells (ESCs) overexpressing the vascular endothelial growth factor (VEGF) improve cardiac function in mouse models of myocardial ischemia and infarction by mechanisms that are poorly understood. Here we studied the effects of VEGF on cardiomyocyte differentiation of mouse ESCs in vitro. We used flow cytometry to determine the expression of α-myosin heavy chain (α-MHC), cardiac troponin I (cTn-I), and Nkx2.5 in differentiated ESCs. VEGF (20 ng/ml) significantly enhanced α-MHC, cTn-I, and Nkx2.5 expression in differentiated ESCs. Western blot analysis confirmed these findings. We found that VEGF receptor FMS-like tyrosine kinase-1 (Flt-1) and fetal liver kinase-1 (Flk-1) expression increased during ESC differentiation. Antibodies against Flk-1 totally blocked and against Flt-1 partially blocked VEGF-induced NKx2.5-positive-stained cells. The ERK inhibitor PD-098059 abolished VEGF-induced cardiomyocyte differentiation of ESCs. Our results suggest that VEGF promotes cardiomyocyte differentiation predominantly by ERK-mediated Flk-1 activation and, to a lesser extent, by Flt-1 activation. These findings may be of significance for stem cell and growth factor therapies to regenerate failing cardiomyocytes." @default.
• W2155291572 created "2016-06-24" @default.
• W2155291572 creator A5021279688 @default.
• W2155291572 creator A5028279909 @default.
• W2155291572 creator A5036505611 @default.
• W2155291572 creator A5052676364 @default.
• W2155291572 creator A5063427472 @default.
• W2155291572 creator A5070369219 @default.
• W2155291572 creator A5073514975 @default.
• W2155291572 creator A5089576007 @default.
• W2155291572 date "2006-10-01" @default.
• W2155291572 modified "2023-09-23" @default.
• W2155291572 title "Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells" @default.
• W2155291572 cites W1566737177 @default.
• W2155291572 cites W1573821584 @default.
• W2155291572 cites W1606473945 @default.
• W2155291572 cites W1980839209 @default.
• W2155291572 cites W1985712533 @default.
• W2155291572 cites W1991463736 @default.
• W2155291572 cites W1993424990 @default.
• W2155291572 cites W1997302930 @default.
• W2155291572 cites W1997538716 @default.
• W2155291572 cites W1999160414 @default.
• W2155291572 cites W2025265682 @default.
• W2155291572 cites W2028018397 @default.
• W2155291572 cites W2030025004 @default.
• W2155291572 cites W2047415777 @default.
• W2155291572 cites W2064124462 @default.
• W2155291572 cites W2067171325 @default.
• W2155291572 cites W2089449686 @default.
• W2155291572 cites W2093498435 @default.
• W2155291572 cites W2094097843 @default.
• W2155291572 cites W2101577478 @default.
• W2155291572 cites W2102911949 @default.
• W2155291572 cites W2115962469 @default.
• W2155291572 cites W2152910732 @default.
• W2155291572 cites W2166156136 @default.
• W2155291572 cites W2169835977 @default.
• W2155291572 cites W2172264076 @default.
• W2155291572 doi "https://doi.org/10.1152/ajpheart.00363.2005" @default.
• W2155291572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16699073" @default.
• W2155291572 hasPublicationYear "2006" @default.
• W2155291572 type Work @default.
• W2155291572 sameAs 2155291572 @default.
• W2155291572 citedByCount "78" @default.
• W2155291572 countsByYear W21552915722012 @default.
• W2155291572 countsByYear W21552915722013 @default.
• W2155291572 countsByYear W21552915722014 @default.
• W2155291572 countsByYear W21552915722015 @default.
• W2155291572 countsByYear W21552915722016 @default.
• W2155291572 countsByYear W21552915722017 @default.
• W2155291572 countsByYear W21552915722018 @default.
• W2155291572 countsByYear W21552915722019 @default.
• W2155291572 countsByYear W21552915722020 @default.
• W2155291572 countsByYear W21552915722021 @default.
• W2155291572 countsByYear W21552915722022 @default.
• W2155291572 countsByYear W21552915722023 @default.
• W2155291572 crossrefType "journal-article" @default.
• W2155291572 hasAuthorship W2155291572A5021279688 @default.
• W2155291572 hasAuthorship W2155291572A5028279909 @default.
• W2155291572 hasAuthorship W2155291572A5036505611 @default.
• W2155291572 hasAuthorship W2155291572A5052676364 @default.
• W2155291572 hasAuthorship W2155291572A5063427472 @default.
• W2155291572 hasAuthorship W2155291572A5070369219 @default.
• W2155291572 hasAuthorship W2155291572A5073514975 @default.
• W2155291572 hasAuthorship W2155291572A5089576007 @default.
• W2155291572 hasConcept C104317684 @default.
• W2155291572 hasConcept C145103041 @default.
• W2155291572 hasConcept C146285616 @default.
• W2155291572 hasConcept C14858245 @default.
• W2155291572 hasConcept C148738053 @default.
• W2155291572 hasConcept C167734588 @default.
• W2155291572 hasConcept C2777025900 @default.
• W2155291572 hasConcept C28328180 @default.
• W2155291572 hasConcept C502942594 @default.
• W2155291572 hasConcept C55493867 @default.
• W2155291572 hasConcept C86803240 @default.
• W2155291572 hasConcept C95444343 @default.
• W2155291572 hasConceptScore W2155291572C104317684 @default.
• W2155291572 hasConceptScore W2155291572C145103041 @default.
• W2155291572 hasConceptScore W2155291572C146285616 @default.
• W2155291572 hasConceptScore W2155291572C14858245 @default.
• W2155291572 hasConceptScore W2155291572C148738053 @default.
• W2155291572 hasConceptScore W2155291572C167734588 @default.
• W2155291572 hasConceptScore W2155291572C2777025900 @default.
• W2155291572 hasConceptScore W2155291572C28328180 @default.
• W2155291572 hasConceptScore W2155291572C502942594 @default.
• W2155291572 hasConceptScore W2155291572C55493867 @default.
• W2155291572 hasConceptScore W2155291572C86803240 @default.
• W2155291572 hasConceptScore W2155291572C95444343 @default.
• W2155291572 hasIssue "4" @default.
• W2155291572 hasLocation W21552915721 @default.
• W2155291572 hasLocation W21552915722 @default.
• W2155291572 hasOpenAccess W2155291572 @default.
• W2155291572 hasPrimaryLocation W21552915721 @default.
• W2155291572 hasRelatedWork W1978835772 @default.
• W2155291572 hasRelatedWork W1994428356 @default.
• W2155291572 hasRelatedWork W2009519731 @default.

• next