FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155294911> ?p ?o ?g. }

• W2155294911 endingPage "321" @default.
• W2155294911 startingPage "303" @default.
• W2155294911 abstract "A striking feature of vestibular hair cells is the polarized arrangement of their stereocilia as the basis for their directional sensitivity. In mammals, each of the vestibular end organs is characterized by a distinct distribution of these polarized cells. We utilized the technique of post-fixation transganglionic neuronal tracing with fluorescent lipid soluble dyes in embryonic and postnatal mice to investigate whether these polarity characteristics correlate with the pattern of connections between the endorgans and their central targets; the vestibular nuclei and cerebellum. We found that the cerebellar and brainstem projections develop independently from each other and have a non-overlapping distribution of neurons and afferents from E11.5 on. In addition, we show that the vestibular fibers projecting to the cerebellum originate preferentially from the lateral half of the utricular macula and the medial half of the saccular macula. In contrast, the brainstem vestibular afferents originate primarily from the medial half of the utricular macula and the lateral half of the saccular macula. This indicates that the line of hair cell polarity reversal within the striola region segregates almost mutually exclusive central projections. A possible interpretation of this feature is that this macular organization provides an inhibitory side-loop through the cerebellum to produce synergistic tuning effects in the vestibular nuclei. The canal cristae project to the brainstem vestibular nuclei and cerebellum, but the projection to the vestibulocerebellum originates preferentially from the superior half of each of the cristae. The reason for this pattern is not clear, but it may compensate for unequal activation of crista hair cells or may be an evolutionary atavism reflecting a different polarity organization in ancestral vertebrate ears." @default.
• W2155294911 created "2016-06-24" @default.
• W2155294911 creator A5011198378 @default.
• W2155294911 creator A5046376366 @default.
• W2155294911 creator A5050109541 @default.
• W2155294911 creator A5051779708 @default.
• W2155294911 date "2010-04-28" @default.
• W2155294911 modified "2023-10-01" @default.
• W2155294911 title "Development and organization of polarity-specific segregation of primary vestibular afferent fibers in mice" @default.
• W2155294911 cites W12432200 @default.
• W2155294911 cites W126784337 @default.
• W2155294911 cites W1499742058 @default.
• W2155294911 cites W1536145277 @default.
• W2155294911 cites W1578218034 @default.
• W2155294911 cites W1774701979 @default.
• W2155294911 cites W1909729046 @default.
• W2155294911 cites W1963661504 @default.
• W2155294911 cites W1964085078 @default.
• W2155294911 cites W1965800882 @default.
• W2155294911 cites W1966680085 @default.
• W2155294911 cites W1967175995 @default.
• W2155294911 cites W1972785174 @default.
• W2155294911 cites W1975551621 @default.
• W2155294911 cites W1978354959 @default.
• W2155294911 cites W1983747135 @default.
• W2155294911 cites W1986394594 @default.
• W2155294911 cites W1986587813 @default.
• W2155294911 cites W1987616121 @default.
• W2155294911 cites W1989874711 @default.
• W2155294911 cites W1993894206 @default.
• W2155294911 cites W1995145501 @default.
• W2155294911 cites W2000948494 @default.
• W2155294911 cites W2002717761 @default.
• W2155294911 cites W2003941049 @default.
• W2155294911 cites W2008342191 @default.
• W2155294911 cites W2009133224 @default.
• W2155294911 cites W2013871508 @default.
• W2155294911 cites W2014871456 @default.
• W2155294911 cites W2015189079 @default.
• W2155294911 cites W2026910342 @default.
• W2155294911 cites W2032391956 @default.
• W2155294911 cites W2036195920 @default.
• W2155294911 cites W2041998716 @default.
• W2155294911 cites W2043748064 @default.
• W2155294911 cites W2044136406 @default.
• W2155294911 cites W2048901211 @default.
• W2155294911 cites W2049264655 @default.
• W2155294911 cites W2050785191 @default.
• W2155294911 cites W2050991079 @default.
• W2155294911 cites W2051077149 @default.
• W2155294911 cites W2052677227 @default.
• W2155294911 cites W2054758021 @default.
• W2155294911 cites W2054820483 @default.
• W2155294911 cites W2057372009 @default.
• W2155294911 cites W2059108193 @default.
• W2155294911 cites W2059407824 @default.
• W2155294911 cites W2060818342 @default.
• W2155294911 cites W2067985560 @default.
• W2155294911 cites W2069552301 @default.
• W2155294911 cites W2070411645 @default.
• W2155294911 cites W2071814459 @default.
• W2155294911 cites W2072931543 @default.
• W2155294911 cites W2073853212 @default.
• W2155294911 cites W2077093189 @default.
• W2155294911 cites W2077483496 @default.
• W2155294911 cites W2077608089 @default.
• W2155294911 cites W2079167165 @default.
• W2155294911 cites W2082262420 @default.
• W2155294911 cites W2087994718 @default.
• W2155294911 cites W2095132896 @default.
• W2155294911 cites W2095871457 @default.
• W2155294911 cites W2097452244 @default.
• W2155294911 cites W2098650397 @default.
• W2155294911 cites W2121183422 @default.
• W2155294911 cites W2133030978 @default.
• W2155294911 cites W2139257559 @default.
• W2155294911 cites W2146354040 @default.
• W2155294911 cites W2148745966 @default.
• W2155294911 cites W2183683480 @default.
• W2155294911 cites W2188697221 @default.
• W2155294911 cites W2231128173 @default.
• W2155294911 cites W2261672728 @default.
• W2155294911 cites W2291168046 @default.
• W2155294911 cites W2300781706 @default.
• W2155294911 cites W2331701228 @default.
• W2155294911 cites W2339401365 @default.
• W2155294911 cites W235028582 @default.
• W2155294911 cites W2400299331 @default.
• W2155294911 cites W2402659601 @default.
• W2155294911 cites W2414084070 @default.
• W2155294911 cites W2887848021 @default.
• W2155294911 cites W321682498 @default.
• W2155294911 cites W61129241 @default.
• W2155294911 cites W863354 @default.
• W2155294911 doi "https://doi.org/10.1007/s00441-010-0944-1" @default.
• W2155294911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2953634" @default.
• W2155294911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20424840" @default.
• W2155294911 hasPublicationYear "2010" @default.

• next