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- W2155297918 abstract "The chemotherapeutic activity and the toxicity of some nitroheterocycles used in antiparasitic therapy (aminitrozole, 2-α-thenoylamino-5-nitrothiazole, niridazole, furazolidone, nifuratel and metronidazole) were compared in laboratory tests. Metronidazole appeared as the most active compound against trichomoniasis and amoebiasis and had in addition the widest safety margin; it also had the highest therapeutic index against lambliasis. Niridazole while showing activity against these protozoa had a less favourable therapeutic index but was the only one which was very active against bilharziasis. Furazolidone appeared as a specially good antibacterial agent with a good activity against Iambliasis. Aminitrozole showed a wide spectrum of activity; its safety margin was slightly lower, however. The other two (2-α-thenoylamino-5-nitrothiazole and nifuratel) were less active and showed a narrower spectrum of activity." @default.
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- W2155297918 date "1970-08-01" @default.
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- W2155297918 title "Laboratory Studies of the Chemotherapeutic Activity and Toxicity of Some Nitroheterocycles" @default.
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- W2155297918 doi "https://doi.org/10.3109/inf.1970.2.issue-2.11" @default.
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